SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5c3l NUCLEOPORIN NUP58
(Xenopus
laevis) 		4 / 4 THR B 349
LEU B 353
LEU B 360
GLN B 363
 None
 0.85A 1fbmA-5c3lB:
undetectable		 1fbmA-5c3lB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5c3l NUCLEOPORIN NUP62
NUP54
(Xenopus
laevis) 		4 / 6 GLU A 388
LEU A 389
VAL C 407
MET C 404
 None
 1.06A 1hk1A-5c3lA:
undetectable		 1hk1A-5c3lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5c3l NUCLEOPORIN NUP58
NUCLEOPORIN NUP62
(Xenopus
laevis) 		4 / 8 GLN B 397
LEU C 469
LYS C 470
LEU C 476
 None
 0.69A 2xn3A-5c3lB:
undetectable
2xn3B-5c3lB:
undetectable		 2xn3A-5c3lB:
17.51
2xn3B-5c3lB:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5c3l NUP54
NUCLEOPORIN NUP58
NUCLEOPORIN NUP62
(Xenopus
laevis;
Xenopus
laevis;
Xenopus
laevis) 		5 / 12 GLN A 402
GLN C 425
LEU C 418
LEU B 345
THR B 349
 None
 1.20A 3fsuA-5c3lA:
undetectable		 3fsuA-5c3lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5c3l NUCLEOPORIN NUP58
NUCLEOPORIN NUP62
NUP54
(Xenopus
laevis) 		5 / 12 LEU A 438
GLN A 446
TYR C 459
PHE B 387
LEU A 415
 None
 1.34A 3gwuA-5c3lA:
undetectable		 3gwuA-5c3lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 5c3l NANOBODY NB15
(Camelus
dromedarius) 		5 / 11 LEU D  79
LEU D  81
VAL D  47
ASP D  50
VAL D  48
 None
 1.28A 3lxiB-5c3lD:
undetectable		 3lxiB-5c3lD:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5c3l NANOBODY NB15
(Camelus
dromedarius) 		5 / 11 PHE D  29
GLY D  52
GLY D  55
ASN D  74
ILE D  58
 None
 0.98A 3owxA-5c3lD:
undetectable
3owxB-5c3lD:
undetectable		 3owxA-5c3lD:
20.87
3owxB-5c3lD:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5c3l NANOBODY NB15
(Camelus
dromedarius) 		5 / 11 VAL D  47
PHE D  29
GLY D  55
ASN D  74
ILE D  58
 None
 1.48A 3owxA-5c3lD:
undetectable
3owxB-5c3lD:
undetectable		 3owxA-5c3lD:
20.87
3owxB-5c3lD:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5c3l NUCLEOPORIN NUP58
(Xenopus
laevis) 		4 / 7 ASN B 373
ALA B 375
PRO B 376
ALA B 359
 None
 0.96A 3twpA-5c3lB:
undetectable		 3twpA-5c3lB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5c3l NUCLEOPORIN NUP58
(Xenopus
laevis) 		4 / 7 ASN B 373
ALA B 375
PRO B 376
ALA B 359
 None
 0.98A 3twpB-5c3lB:
undetectable		 3twpB-5c3lB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5c3l NUCLEOPORIN NUP58
(Xenopus
laevis) 		4 / 7 ASN B 373
ALA B 375
PRO B 376
ALA B 359
 None
 0.97A 3twpC-5c3lB:
undetectable		 3twpC-5c3lB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5c3l NUCLEOPORIN NUP58
(Xenopus
laevis) 		4 / 5 ASN B 373
ALA B 375
PRO B 376
ALA B 359
 None
 0.98A 3twpD-5c3lB:
undetectable		 3twpD-5c3lB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5c3l NUCLEOPORIN NUP58
NUP54
(Xenopus
laevis) 		4 / 4 ASN A 392
SER B 329
LEU B 328
THR A 396
 None
 1.36A 4an2A-5c3lA:
undetectable		 4an2A-5c3lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5c3l NANOBODY NB15
(Camelus
dromedarius) 		5 / 10 LEU D  79
LEU D  81
VAL D  47
ASP D  50
VAL D  48
 None
 1.25A 4c9pB-5c3lD:
undetectable		 4c9pB-5c3lD:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5c3l NUP54
NUCLEOPORIN NUP62
(Xenopus
laevis;
Xenopus
laevis) 		4 / 5 LYS C 426
LEU C 428
GLU C 429
LEU A 410
 None
 1.37A 4k4yI-5c3lC:
undetectable		 4k4yI-5c3lC:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5c3l NUP54
NUCLEOPORIN NUP62
(Xenopus
laevis;
Xenopus
laevis) 		4 / 5 GLN A 416
LEU A 415
SER A 411
ASP C 475
 None
 1.16A 4qtuD-5c3lA:
undetectable		 4qtuD-5c3lA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 5c3l NUP54
(Xenopus
laevis) 		4 / 5 ASP A 333
VAL A 332
TRP A 337
GLU A 338
 None
 1.26A 4qzuA-5c3lA:
undetectable
4qzuD-5c3lA:
undetectable		 4qzuA-5c3lA:
17.80
4qzuD-5c3lA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5c3l NUP54
NUCLEOPORIN NUP58
(Xenopus
laevis;
Xenopus
laevis) 		3 / 3 ALA B 313
GLN A 368
THR A 372
 None
 0.76A 5n0oA-5c3lB:
undetectable		 5n0oA-5c3lB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c3l NUCLEOPORIN NUP62
(Xenopus
laevis) 		4 / 5 LEU C 469
LYS C 470
ALA C 473
LEU C 476
 None
 0.83A 5vkqA-5c3lC:
undetectable
5vkqD-5c3lC:
undetectable		 5vkqA-5c3lC:
6.84
5vkqD-5c3lC:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c3l NUCLEOPORIN NUP62
(Xenopus
laevis) 		4 / 5 LEU C 469
LYS C 470
ALA C 473
LEU C 476
 None
 0.82A 5vkqA-5c3lC:
undetectable
5vkqB-5c3lC:
undetectable		 5vkqA-5c3lC:
6.84
5vkqB-5c3lC:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c3l NUCLEOPORIN NUP62
(Xenopus
laevis) 		4 / 5 LEU C 469
LYS C 470
ALA C 473
LEU C 476
 None
 0.82A 5vkqB-5c3lC:
undetectable
5vkqC-5c3lC:
undetectable		 5vkqB-5c3lC:
6.84
5vkqC-5c3lC:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c3l NUCLEOPORIN NUP62
(Xenopus
laevis) 		4 / 5 LEU C 469
LYS C 470
ALA C 473
LEU C 476
 None
 0.82A 5vkqC-5c3lC:
undetectable
5vkqD-5c3lC:
undetectable		 5vkqC-5c3lC:
6.84
5vkqD-5c3lC:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5c3l NUCLEOPORIN NUP58
NANOBODY NB15
(Xenopus
laevis;
Camelus
dromedarius) 		3 / 3 GLN B 363
TYR D 100
ASN D  98
 None
 1.05A 6dwdC-5c3lB:
undetectable		 6dwdC-5c3lB:
15.40