SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 324
LEU A  20
VAL A  33
ILE A  66
ILE A  68
 None
 0.99A 1epbA-5c3mA:
undetectable		 1epbA-5c3mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A  48
VAL A  51
GLY A  52
VAL A  21
 None
 0.52A 1p2yA-5c3mA:
undetectable		 1p2yA-5c3mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 THR A  85
PHE A 148
PHE A  83
LEU A  24
 None
 0.91A 1qcaA-5c3mA:
undetectable		 1qcaA-5c3mA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A  89
GLN A  87
PHE A  88
ASN A 150
 None
None
None
MN  A 501 (-3.4A)
 1.29A 1rs6A-5c3mA:
undetectable		 1rs6A-5c3mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A  89
GLN A  87
PHE A  88
ASN A 150
 None
None
None
MN  A 501 (-3.4A)
 1.32A 1rs6B-5c3mA:
undetectable		 1rs6B-5c3mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 434
GLU A 432
ALA A 429
LEU A 427
 None
 1.17A 1sn5A-5c3mA:
undetectable		 1sn5A-5c3mA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 258
ALA A 198
ILE A 345
VAL A 377
ALA A 376
 None
 1.30A 1udtA-5c3mA:
undetectable		 1udtA-5c3mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 395
ALA A 392
 None
 1.33A 2bm9A-5c3mA:
5.5		 2bm9A-5c3mA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 392
 None
 1.11A 2br4A-5c3mA:
5.3		 2br4A-5c3mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 392
 None
 1.15A 2br4C-5c3mA:
undetectable		 2br4C-5c3mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 392
 None
 1.18A 2br4D-5c3mA:
5.4		 2br4D-5c3mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 392
 None
 1.09A 2br4E-5c3mA:
5.4		 2br4E-5c3mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 392
 None
 1.14A 2br4F-5c3mA:
undetectable		 2br4F-5c3mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 122
GLY A 118
ASN A 150
ARG A  74
PHE A  88
 None
None
MN  A 501 (-3.4A)
None
None
 1.13A 2okcA-5c3mA:
4.2		 2okcA-5c3mA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 122
GLY A 118
ASN A 150
ARG A  74
PHE A  88
 None
None
MN  A 501 (-3.4A)
None
None
 1.16A 2okcB-5c3mA:
4.0		 2okcB-5c3mA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 130
GLN A 165
THR A 163
THR A 125
 None
 1.40A 2zj0C-5c3mA:
5.5		 2zj0C-5c3mA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A 130
GLN A 165
THR A 163
THR A 125
 None
 1.37A 2zj0D-5c3mA:
5.9		 2zj0D-5c3mA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A  89
GLN A  87
PHE A  88
ASN A 150
 None
None
None
MN  A 501 (-3.4A)
 1.29A 3n66B-5c3mA:
undetectable		 3n66B-5c3mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 LYS A 385
LEU A 200
LEU A 207
GLY A 371
ASP A 372
 None
 1.44A 3sfuC-5c3mA:
undetectable		 3sfuC-5c3mA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A  80
ALA A  81
ASP A  82
VAL A  33
GLY A  34
 None
 0.78A 3ufnA-5c3mA:
undetectable		 3ufnA-5c3mA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 270
GLU A 271
TYR A 260
HIS A 202
 None
None
None
MN  A 501 (-3.4A)
 1.33A 4a97J-5c3mA:
undetectable		 4a97J-5c3mA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 270
GLU A 271
TYR A 260
HIS A 258
 None
 1.29A 4a97J-5c3mA:
undetectable		 4a97J-5c3mA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 THR A 113
GLY A 115
ARG A 259
ILE A 109
 None
 1.11A 4ac9C-5c3mA:
4.1		 4ac9C-5c3mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 THR A 113
GLY A 115
ARG A 259
ILE A 109
 None
 1.11A 4acaC-5c3mA:
4.1		 4acaC-5c3mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 THR A 113
GLY A 115
ARG A 259
ILE A 109
 None
 1.06A 4acbC-5c3mA:
4.1		 4acbC-5c3mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 ASN A 201
ALA A 152
GLY A 153
THR A 156
 MN  A 501 (-3.5A)
MN  A 501 ( 4.7A)
None
None
 1.28A 4bboC-5c3mA:
undetectable		 4bboC-5c3mA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 121
THR A 125
ILE A  10
 None
 0.85A 4e0fB-5c3mA:
undetectable		 4e0fB-5c3mA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLN A  87
THR A 113
HIS A 202
ASN A 147
 None
None
MN  A 501 (-3.4A)
None
 1.33A 4pfjB-5c3mA:
6.0		 4pfjB-5c3mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 CYH A 255
ASN A 150
GLU A 355
TYR A 257
 None
MN  A 501 (-3.4A)
None
None
 1.38A 4wcxC-5c3mA:
undetectable		 4wcxC-5c3mA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A  89
GLN A  87
PHE A  88
ASN A 150
 None
None
None
MN  A 501 (-3.4A)
 1.35A 5vuoB-5c3mA:
undetectable		 5vuoB-5c3mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 174
VAL A 204
GLY A 206
THR A 217
LEU A 247
 None
 1.19A 5x24A-5c3mA:
undetectable		 5x24A-5c3mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 282
ARG A  96
GLN A 111
GLY A 313
ALA A 314
 None
 0.93A 5xxiA-5c3mA:
undetectable		 5xxiA-5c3mA:
20.61