SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		5 / 9 ASN A 187
ILE A 188
GLY A 124
ASN A 133
LEU A 191
 None
 1.23A 1dgmA-5c3oA:
undetectable		 1dgmA-5c3oA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JD0_A_AZMA1400_1
(CARBONIC ANHYDRASE
XII)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		5 / 9 HIS A 214
HIS A 271
VAL A 273
LEU A 223
THR A 221
 CA  A 407 (-3.4A)
CA  A 407 (-3.4A)
None
None
None
 1.40A 1jd0A-5c3oA:
undetectable		 1jd0A-5c3oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		6 / 12 HIS A 214
ASP A 216
LEU A 231
HIS A 271
SER A 288
PHE A 292
 CA  A 407 (-3.4A)
CA  A 407 (-2.5A)
None
CA  A 407 (-3.4A)
None
None
 0.82A 1uobA-5c3oA:
23.3		 1uobA-5c3oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		5 / 12 SER A 120
HIS A 214
ASP A 216
HIS A 271
PHE A 292
 EDO  A 406 (-3.5A)
CA  A 407 (-3.4A)
CA  A 407 (-2.5A)
CA  A 407 (-3.4A)
None
 1.05A 1uobA-5c3oA:
23.3		 1uobA-5c3oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		5 / 11 HIS A 214
ASP A 216
HIS A 271
VAL A 273
ARG A 286
 CA  A 407 (-3.4A)
CA  A 407 (-2.5A)
CA  A 407 (-3.4A)
None
None
 1.34A 1uofA-5c3oA:
22.6		 1uofA-5c3oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		6 / 11 HIS A 214
ASP A 216
THR A 221
HIS A 271
VAL A 273
SER A 288
 CA  A 407 (-3.4A)
CA  A 407 (-2.5A)
None
CA  A 407 (-3.4A)
None
None
 0.70A 1uofA-5c3oA:
22.6		 1uofA-5c3oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		5 / 11 GLY A  44
ALA A  43
ILE A  36
ALA A   5
ILE A  13
 None
 1.01A 2b60B-5c3oA:
undetectable		 2b60B-5c3oA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		4 / 7 TYR A 291
ASN A 150
ASP A 154
LYS A 157
 None
 1.35A 3lslA-5c3oA:
undetectable
3lslD-5c3oA:
undetectable		 3lslA-5c3oA:
23.32
3lslD-5c3oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		4 / 7 TYR A 291
ASN A 150
ASP A 154
LYS A 157
 None
 1.32A 3lslA-5c3oA:
undetectable
3lslD-5c3oA:
undetectable		 3lslA-5c3oA:
23.32
3lslD-5c3oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		4 / 6 TYR A 291
ASN A 150
ASP A 154
LYS A 157
 None
 1.27A 3lslG-5c3oA:
undetectable		 3lslG-5c3oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		4 / 8 ILE A  53
GLN A 155
ALA A 158
LEU A 159
 EDO  A 403 (-4.7A)
None
None
None
 0.86A 3ozwA-5c3oA:
undetectable		 3ozwA-5c3oA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		5 / 9 HIS A 214
HIS A 271
VAL A 273
LEU A 223
THR A 221
 CA  A 407 (-3.4A)
CA  A 407 (-3.4A)
None
None
None
 1.38A 4coqB-5c3oA:
undetectable		 4coqB-5c3oA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		4 / 8 ASP A 216
PHE A  45
VAL A 233
HIS A 214
 CA  A 407 (-2.5A)
None
None
CA  A 407 (-3.4A)
 1.20A 4f5zA-5c3oA:
undetectable		 4f5zA-5c3oA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		5 / 11 ILE A 220
THR A 221
ALA A 290
LEU A 222
TYR A  47
 None
 1.11A 4g1bB-5c3oA:
undetectable		 4g1bB-5c3oA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		3 / 3 CYH A 156
LYS A 157
HIS A 160
 None
 0.43A 5js5A-5c3oA:
undetectable		 5js5A-5c3oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5c3o THYMINE DIOXYGENASE
(Neurospora
crassa) 		4 / 6 GLU A 122
ARG A 190
PHE A 292
PRO A 295
 None
 1.23A 6fgdA-5c3oA:
undetectable		 6fgdA-5c3oA:
22.30