SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		3 / 3 ALA A 133
VAL A 100
TRP A 126
 None
 0.88A 1av2C-5c3uA:
undetectable
1av2D-5c3uA:
undetectable		 1av2C-5c3uA:
5.17
1av2D-5c3uA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.10A 2aylA-5c3uA:
undetectable		 2aylA-5c3uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 5 ILE A  98
LEU A 119
SER A 117
ARG A 113
 None
 0.99A 2byoA-5c3uA:
undetectable		 2byoA-5c3uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ALA A 285
GLY A 283
ALA A 263
VAL A  38
LEU A 301
 None
 0.99A 2nyuA-5c3uA:
2.2		 2nyuA-5c3uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ALA A 285
GLY A 283
ALA A 263
VAL A 307
LEU A 298
 None
 1.04A 2nyuA-5c3uA:
2.2		 2nyuA-5c3uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		3 / 3 GLU A 246
SER A 241
VAL A 240
 None
 0.84A 3eeoA-5c3uA:
2.1		 3eeoA-5c3uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.08A 3ln1C-5c3uA:
undetectable		 3ln1C-5c3uA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.03A 3nt1A-5c3uA:
undetectable		 3nt1A-5c3uA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.00A 3nt1B-5c3uA:
undetectable		 3nt1B-5c3uA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 5 ASN A 186
GLU A 279
THR A 233
SER A 244
 None
PLP  A 401 ( 4.0A)
None
None
 1.29A 3p2kC-5c3uA:
2.4		 3p2kC-5c3uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 7 ASP A 148
PHE A  59
ILE A 142
ARG A 134
 None
 1.00A 3pglA-5c3uA:
undetectable		 3pglA-5c3uA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ASN A 186
ILE A 189
GLY A 182
VAL A 202
VAL A 253
 None
None
PLP  A 401 (-3.4A)
None
None
 1.03A 3rukB-5c3uA:
undetectable		 3rukB-5c3uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 7 GLU A 279
THR A  81
VAL A  82
LEU A  83
 PLP  A 401 ( 4.0A)
None
None
None
 1.00A 3uniA-5c3uA:
undetectable		 3uniA-5c3uA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		3 / 3 THR A 127
VAL A 131
GLU A 124
 None
 0.71A 3v4tA-5c3uA:
undetectable
3v4tD-5c3uA:
undetectable		 3v4tA-5c3uA:
24.36
3v4tD-5c3uA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 10 GLY A 181
ALA A 204
VAL A 179
SER A 147
VAL A 240
 PLP  A 401 (-3.7A)
None
PLP  A 401 ( 4.1A)
PLP  A 401 (-2.6A)
None
 1.16A 4da7A-5c3uA:
undetectable		 4da7A-5c3uA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 SER A 287
LEU A 286
PRO A 178
ALA A 232
GLY A 314
 None
None
PLP  A 401 ( 4.4A)
None
PLP  A 401 ( 4.0A)
 1.23A 4j7xB-5c3uA:
undetectable		 4j7xB-5c3uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 8 LEU A  92
VAL A  94
VAL A 144
ILE A 142
 None
 0.79A 4l4cB-5c3uA:
undetectable		 4l4cB-5c3uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ASN A 186
ILE A 189
GLY A 182
VAL A 202
VAL A 253
 None
None
PLP  A 401 (-3.4A)
None
None
 1.02A 4nkvA-5c3uA:
undetectable		 4nkvA-5c3uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ASN A 186
ILE A 189
GLY A 182
VAL A 202
VAL A 253
 None
None
PLP  A 401 (-3.4A)
None
None
 1.00A 4nkvB-5c3uA:
undetectable		 4nkvB-5c3uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ASN A 186
ILE A 189
GLY A 182
VAL A 202
VAL A 253
 None
None
PLP  A 401 (-3.4A)
None
None
 1.01A 4nkvC-5c3uA:
undetectable		 4nkvC-5c3uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ASN A 186
ILE A 189
GLY A 182
VAL A 202
VAL A 253
 None
None
PLP  A 401 (-3.4A)
None
None
 1.01A 4nkvD-5c3uA:
undetectable		 4nkvD-5c3uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 ASN A 186
ILE A 189
GLY A 182
VAL A 202
VAL A 253
 None
None
PLP  A 401 (-3.4A)
None
None
 1.05A 4nkxA-5c3uA:
undetectable		 4nkxA-5c3uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 9 VAL A 309
ALA A 174
ARG A 295
ILE A 294
ILE A 203
 None
 1.27A 4oknB-5c3uA:
undetectable		 4oknB-5c3uA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 5 THR A 230
THR A 207
ASP A 260
TYR A 329
 None
 1.36A 4oltA-5c3uA:
undetectable		 4oltA-5c3uA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 5 THR A 230
THR A 207
ASP A 260
TYR A 329
 None
 1.37A 4oltB-5c3uA:
undetectable		 4oltB-5c3uA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 5 THR A 230
THR A 207
ASP A 260
TYR A 329
 None
 1.36A 4qwpA-5c3uA:
undetectable		 4qwpA-5c3uA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 9 ILE A 317
GLU A 279
VAL A  82
LEU A  83
ILE A 112
 None
PLP  A 401 ( 4.0A)
None
None
None
 1.34A 4r38C-5c3uA:
undetectable		 4r38C-5c3uA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.15A 4rrwA-5c3uA:
undetectable		 4rrwA-5c3uA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.15A 4rrzA-5c3uA:
undetectable		 4rrzA-5c3uA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 6 ASN A 186
GLU A 206
LEU A 245
PHE A 213
 None
 1.03A 4twdD-5c3uA:
undetectable
4twdE-5c3uA:
undetectable		 4twdD-5c3uA:
22.02
4twdE-5c3uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 6 ASN A 186
GLU A 206
LEU A 245
PHE A 213
 None
 0.86A 4twdI-5c3uA:
undetectable
4twdJ-5c3uA:
undetectable		 4twdI-5c3uA:
22.02
4twdJ-5c3uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 GLY A 180
GLY A 182
GLY A 183
LEU A 184
GLU A 206
 PLP  A 401 (-3.4A)
PLP  A 401 (-3.4A)
PLP  A 401 (-3.3A)
PLP  A 401 (-4.6A)
None
 0.95A 5c0oF-5c3uA:
3.3		 5c0oF-5c3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		4 / 4 VAL A 179
GLU A 206
GLY A 182
LEU A 185
 PLP  A 401 ( 4.1A)
None
PLP  A 401 (-3.4A)
None
 1.31A 5g5gC-5c3uA:
undetectable		 5g5gC-5c3uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.15A 5ikrA-5c3uA:
undetectable		 5ikrA-5c3uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		3 / 3 MET A 330
GLU A 272
ARG A 326
 None
 1.11A 5tjyA-5c3uA:
undetectable		 5tjyA-5c3uA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5c3u L-SERINE
AMMONIA-LYASE
(Rhizomucor
miehei) 		5 / 12 SER A 281
ALA A 266
TYR A 325
ALA A 263
GLY A 283
 PLP  A 401 (-4.5A)
None
None
None
None
 1.24A 5tzoC-5c3uA:
undetectable		 5tzoC-5c3uA:
18.68