SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		4 / 6 HIS E 672
ILE E 671
ALA E 666
VAL E 598
 None
None
None
BQR  E 803 (-3.8A)
 1.05A 1hk1A-5c4gE:
undetectable		 1hk1A-5c4gE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		5 / 11 ILE E 588
GLU E 310
THR E 356
LEU E 210
GLY E 593
 None
 1.37A 2fn1A-5c4gE:
undetectable		 2fn1A-5c4gE:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		4 / 6 TYR E 385
THR E 369
ALA E 517
PRO E 367
 None
SO4  E 802 (-2.8A)
None
None
 1.31A 2ql8A-5c4gE:
undetectable
2ql8B-5c4gE:
undetectable		 2ql8A-5c4gE:
16.82
2ql8B-5c4gE:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		5 / 11 LEU E 567
ALA E 724
ALA E 725
VAL E 563
LEU E 757
 None
 0.99A 3bszE-5c4gE:
undetectable		 3bszE-5c4gE:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		4 / 6 LEU E 518
GLU E 520
PRO E 521
ARG E 528
 None
 1.37A 3ltwA-5c4gE:
undetectable		 3ltwA-5c4gE:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		5 / 12 SER E 641
LEU E 615
PHE E 619
ILE E 670
GLY E 705
 None
 0.96A 3nxuA-5c4gE:
undetectable		 3nxuA-5c4gE:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		5 / 12 ALA E 357
LEU E 354
LEU E 317
ALA E 371
LEU E 383
 None
None
None
None
BQR  E 803 ( 4.3A)
 1.15A 3ozuA-5c4gE:
undetectable		 3ozuA-5c4gE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		5 / 12 LEU E 354
VAL E 386
LEU E 317
ALA E 371
LEU E 383
 None
None
None
None
BQR  E 803 ( 4.3A)
 1.30A 3ozuA-5c4gE:
undetectable		 3ozuA-5c4gE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		4 / 8 TYR E 197
ILE E 141
ILE E 145
ILE E 160
 None
 0.79A 3p4wC-5c4gE:
undetectable		 3p4wC-5c4gE:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		3 / 3 TYR E 713
MET E 777
LEU E 647
 None
 0.97A 3vw1D-5c4gE:
2.7		 3vw1D-5c4gE:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		4 / 7 VAL E 607
VAL E 702
PHE E 699
ILE E 662
 None
 0.97A 3zjqA-5c4gE:
undetectable		 3zjqA-5c4gE:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		4 / 7 VAL E 607
VAL E 702
PHE E 699
ILE E 662
 None
 0.96A 3zjqB-5c4gE:
undetectable		 3zjqB-5c4gE:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		3 / 3 SER E 743
TYR E 219
PRO E 746
 None
 0.98A 4kbeA-5c4gE:
undetectable		 4kbeA-5c4gE:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		3 / 3 LEU E 719
ILE E 723
ARG E 726
 None
 0.51A 4mk4B-5c4gE:
undetectable		 4mk4B-5c4gE:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA
(Homo
sapiens) 		5 / 12 PRO E 381
ILE E 547
TYR E 583
VAL E 598
ILE E 673
 BQR  E 803 ( 4.7A)
BQR  E 803 ( 4.7A)
BQR  E 803 ( 3.0A)
BQR  E 803 (-3.8A)
BQR  E 803 ( 3.9A)
 0.63A 4xe0A-5c4gE:
15.6		 4xe0A-5c4gE:
21.08