SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_C_HSMC1161_1 (ALLERGEN ARG R 1)	5c4q	BROMODOMAIN (Leishmania donovani)	4 / 5	VAL A 48 TYR A 45 VAL A 36 ASP A 53	None UNX A 203 ( 4.4A) BMF A 201 (-4.6A) None	1.31A	2x45C-5c4qA: undetectable	2x45C-5c4qA: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y00_B_Y00B601_2 (BETA-1 ADRENERGIC RECEPTOR)	5c4q	BROMODOMAIN (Leishmania donovani)	3 / 3	VAL A 47 ASN A 87 TRP A 93	None BMF A 201 (-2.8A) BMF A 201 (-3.5A)	1.03A	2y00B-5c4qA: undetectable	2y00B-5c4qA: 15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Y03_A_SALA801_1 (PROTEIN POLYBROMO-1)	5c4q	BROMODOMAIN (Leishmania donovani)	4 / 7	TYR A 44 MET A 79 ALA A 83 ASN A 87	BMF A 201 ( 4.9A) None BMF A 201 ( 4.1A) BMF A 201 (-2.8A)	0.32A	4y03A-5c4qA: 13.3	4y03A-5c4qA: 31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5PBE_A_TYLA2001_1 (BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B)	5c4q	BROMODOMAIN (Leishmania donovani)	4 / 6	VAL A 36 VAL A 41 TYR A 44 ASN A 87	BMF A 201 (-4.6A) BMF A 201 (-4.2A) BMF A 201 ( 4.9A) BMF A 201 (-2.8A)	0.92A	5pbeA-5c4qA: 15.2	5pbeA-5c4qA: 29.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2X45_C_HSMC1161_1","ALLERGEN ARG R 1","5c4q","BROMODOMAIN","Leishmania donovani",4,"VAL A  48;TYR A  45;VAL A  36;ASP A  53","None;UNX A 203 ( 4.4A);BMF A 201 (-4.6A);None","1.31A","2x45C-5c4qA:undetectable","2x45C-5c4qA:18.59"],["2Y00_B_Y00B601_2","BETA-1 ADRENERGIC RECEPTOR","5c4q","BROMODOMAIN","Leishmania donovani",3,"VAL A  47;ASN A  87;TRP A  93","None;BMF A 201 (-2.8A);BMF A 201 (-3.5A)","1.03A","2y00B-5c4qA:undetectable","2y00B-5c4qA:15.13"],["4Y03_A_SALA801_1","PROTEIN POLYBROMO-1","5c4q","BROMODOMAIN","Leishmania donovani",4,"TYR A  44;MET A  79;ALA A  83;ASN A  87","BMF A 201 ( 4.9A);None;BMF A 201 ( 4.1A);BMF A 201 (-2.8A)","0.32A","4y03A-5c4qA:13.3","4y03A-5c4qA:31.75"],["5PBE_A_TYLA2001_1","BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B","5c4q","BROMODOMAIN","Leishmania donovani",4,"VAL A  36;VAL A  41;TYR A  44;ASN A  87","BMF A 201 (-4.6A);BMF A 201 (-4.2A);BMF A 201 ( 4.9A);BMF A 201 (-2.8A)","0.92A","5pbeA-5c4qA:15.2","5pbeA-5c4qA:29.50"]]