SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		7 / 11 CYH A 320
ALA A 327
VAL A 361
ARG A 364
ARG A 367
VAL A 376
LEU A 396
 GOL  A 607 ( 4.0A)
None
None
None
None
None
None
 0.74A 1n4hA-5c4tA:
29.8		 1n4hA-5c4tA:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		7 / 11 CYH A 320
ALA A 327
VAL A 361
ARG A 364
MET A 365
ARG A 367
LEU A 396
 GOL  A 607 ( 4.0A)
None
None
None
None
None
None
 0.79A 1n4hA-5c4tA:
29.8		 1n4hA-5c4tA:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		7 / 11 GLN A 286
CYH A 320
ALA A 327
VAL A 361
ARG A 367
VAL A 376
LEU A 396
 None
GOL  A 607 ( 4.0A)
None
None
None
None
None
 1.05A 1n4hA-5c4tA:
29.8		 1n4hA-5c4tA:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		7 / 11 GLN A 286
CYH A 320
ALA A 327
VAL A 361
MET A 365
ARG A 367
LEU A 396
 None
GOL  A 607 ( 4.0A)
None
None
None
None
None
 1.06A 1n4hA-5c4tA:
29.8		 1n4hA-5c4tA:
49.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 454
SER A 413
ILE A 417
PHE A 412
ILE A 462
 None
 1.36A 1osvB-5c4tA:
19.8		 1osvB-5c4tA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 10 LEU A 353
ALA A 335
LEU A 338
ASP A 348
LEU A 344
 SO4  A 602 ( 4.9A)
None
None
None
None
 1.08A 1yi4A-5c4tA:
undetectable		 1yi4A-5c4tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 12 TYR A 420
PHE A 403
VAL A 361
VAL A 480
LEU A 505
 None
None
None
4Y6  A 601 ( 3.8A)
4Y6  A 601 (-4.0A)
 1.14A 2hc4A-5c4tA:
22.9		 2hc4A-5c4tA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 12 ILE A 397
LEU A 391
CYH A 393
LEU A 475
HIS A 479
 GOL  A 607 (-4.5A)
None
None
None
None
 1.28A 2jn3A-5c4tA:
undetectable		 2jn3A-5c4tA:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		11 / 12 GLN A 286
LEU A 287
LEU A 292
CYH A 320
ALA A 327
ALA A 368
VAL A 376
PHE A 388
CYH A 393
LEU A 396
HIS A 479
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
GOL  A 607 ( 4.5A)
None
None
None
 0.68A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		11 / 12 GLN A 286
LEU A 287
LEU A 292
CYH A 320
ALA A 327
MET A 365
ALA A 368
VAL A 376
PHE A 388
CYH A 393
LEU A 396
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
None
GOL  A 607 ( 4.5A)
None
None
 0.68A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 292
PHE A 388
CYH A 393
LEU A 396
HIS A 479
 None
GOL  A 607 ( 4.5A)
None
None
None
 1.11A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		3 / 3 TRP A 317
VAL A 361
ARG A 367
 None
 0.40A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		10 / 12 GLN A 286
LEU A 292
CYH A 320
ALA A 327
MET A 365
ALA A 368
VAL A 376
PHE A 388
LEU A 391
LEU A 396
 None
None
GOL  A 607 ( 4.0A)
None
None
None
None
GOL  A 607 ( 4.5A)
None
None
 0.61A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		11 / 12 GLN A 286
LEU A 292
TRP A 317
CYH A 320
ALA A 327
ALA A 368
VAL A 376
PHE A 388
LEU A 391
LEU A 396
HIS A 479
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
GOL  A 607 ( 4.5A)
None
None
None
 0.52A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		6 / 12 LEU A 287
TRP A 317
PHE A 388
LEU A 391
LEU A 396
HIS A 479
 None
None
GOL  A 607 ( 4.5A)
None
None
None
 1.17A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		3 / 3 LEU A 287
VAL A 361
ARG A 367
 None
 0.30A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 338
SER A 339
PHE A 341
ILE A 426
LEU A 446
 None
 1.20A 3ko0K-5c4tA:
1.0
3ko0L-5c4tA:
undetectable
3ko0S-5c4tA:
1.1
3ko0T-5c4tA:
undetectable		 3ko0K-5c4tA:
17.08
3ko0L-5c4tA:
17.08
3ko0S-5c4tA:
17.08
3ko0T-5c4tA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 446
LEU A 338
SER A 339
PHE A 341
ILE A 426
 None
 1.17A 3ko0M-5c4tA:
undetectable
3ko0N-5c4tA:
1.1
3ko0O-5c4tA:
undetectable
3ko0P-5c4tA:
undetectable		 3ko0M-5c4tA:
17.08
3ko0N-5c4tA:
17.08
3ko0O-5c4tA:
17.08
3ko0P-5c4tA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		4 / 8 TRP A 314
PHE A 486
GLU A 315
SER A 312
 None
 1.31A 4v3yA-5c4tA:
undetectable
4v3yB-5c4tA:
undetectable		 4v3yA-5c4tA:
20.29
4v3yB-5c4tA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 9 GLN A 286
LEU A 287
LEU A 292
ARG A 367
ALA A 368
 None
 0.95A 5g44A-5c4tA:
34.2		 5g44A-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 9 GLN A 286
LEU A 292
VAL A 363
ARG A 367
ALA A 368
 None
 1.28A 5g44A-5c4tA:
34.2		 5g44A-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		8 / 9 LEU A 287
LEU A 292
ALA A 327
VAL A 361
ARG A 364
MET A 365
ARG A 367
ALA A 368
 None
 0.53A 5g44A-5c4tA:
34.2		 5g44A-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens) 		5 / 12 GLN A 443
VAL A 363
GLY A 356
ALA A 355
LEU A 433
 None
 0.91A 5xxiA-5c4tA:
undetectable		 5xxiA-5c4tA:
19.38