SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 5c53 POL GAMMA B
(Homo
sapiens) 		5 / 10 LEU B 190
ALA B 130
ASP B 129
GLY B 212
VAL B 240
 None
 1.13A 1d4yA-5c53B:
undetectable		 1d4yA-5c53B:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 4 VAL B 120
TRP B 262
TRP B 115
 None
 1.19A 1gmkA-5c53B:
undetectable
1gmkB-5c53B:
undetectable		 1gmkA-5c53B:
2.09
1gmkB-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 4 VAL B 120
TRP B 262
TRP B 115
 None
 1.42A 1gmkC-5c53B:
undetectable
1gmkD-5c53B:
undetectable		 1gmkC-5c53B:
2.09
1gmkD-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5c53 POL GAMMA B
(Homo
sapiens) 		5 / 11 LEU B 442
VAL B 387
MET B 435
LEU B 385
HIS B  77
 None
 1.49A 1kt6A-5c53B:
undetectable		 1kt6A-5c53B:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5c53 POL GAMMA B
(Homo
sapiens) 		5 / 11 LEU B 442
VAL B 387
MET B 435
LEU B 385
HIS B  77
 None
 1.43A 1kt7A-5c53B:
undetectable		 1kt7A-5c53B:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 TRP B 241
ARG B 122
PHE B 254
 None
 1.45A 1zeaH-5c53B:
undetectable
1zeaL-5c53B:
undetectable		 1zeaH-5c53B:
12.56
1zeaL-5c53B:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 THR B 243
PRO B 333
PRO B 205
 None
 0.76A 2d55C-5c53B:
undetectable		 2d55C-5c53B:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 PRO B 205
THR B 243
PRO B 333
 None
 0.77A 2d55C-5c53B:
undetectable		 2d55C-5c53B:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 5c53 POL GAMMA B
(Homo
sapiens) 		4 / 7 LEU B 385
TYR B 432
THR B 440
VAL B 441
 None
 1.10A 2uz2A-5c53B:
undetectable		 2uz2A-5c53B:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5c53 POL GAMMA B
(Homo
sapiens) 		5 / 12 VAL B 338
SER B 117
VAL B 125
GLY B 207
ALA B 209
 None
 1.24A 2x2iA-5c53B:
undetectable		 2x2iA-5c53B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 TRP B 251
VAL B 335
TRP B 255
 None
 1.30A 2xdcC-5c53B:
undetectable
2xdcD-5c53B:
undetectable		 2xdcC-5c53B:
2.09
2xdcD-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 TRP B 251
VAL B 335
TRP B 255
 None
 1.30A 2xdcE-5c53B:
undetectable
2xdcF-5c53B:
undetectable		 2xdcE-5c53B:
2.09
2xdcF-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 TRP B 251
VAL B 335
TRP B 255
 None
 1.26A 2y5mE-5c53B:
undetectable
2y5mF-5c53B:
undetectable		 2y5mE-5c53B:
2.09
2y5mF-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 TRP B 251
VAL B 335
TRP B 255
 None
 1.28A 2y6nC-5c53B:
undetectable
2y6nD-5c53B:
undetectable		 2y6nC-5c53B:
2.09
2y6nD-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 TRP B 251
VAL B 335
TRP B 255
 None
 1.29A 2y6nE-5c53B:
undetectable
2y6nF-5c53B:
undetectable		 2y6nE-5c53B:
2.09
2y6nF-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5c53 POL GAMMA B
(Homo
sapiens) 		4 / 4 LEU B 102
ARG B 458
LEU B 372
ALA B 379
 None
 1.07A 3b9mA-5c53B:
undetectable		 3b9mA-5c53B:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 5c53 POL GAMMA B
(Homo
sapiens) 		5 / 12 GLY B 345
LEU B 299
TYR B 290
GLU B 236
LEU B 110
 None
 1.11A 3vywA-5c53B:
undetectable		 3vywA-5c53B:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 5c53 POL GAMMA B
(Homo
sapiens) 		5 / 9 LEU B 190
ALA B 130
ASP B 129
GLY B 212
VAL B 240
 None
 1.03A 4q1wA-5c53B:
undetectable		 4q1wA-5c53B:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5c53 POL GAMMA B
(Homo
sapiens) 		4 / 7 LEU B 347
THR B 235
LEU B  91
SER B  90
 None
 1.01A 5bojB-5c53B:
undetectable		 5bojB-5c53B:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 TRP B 295
GLU B 298
ASP B  89
 None
 0.80A 5gqbA-5c53B:
undetectable		 5gqbA-5c53B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5c53 POL GAMMA B
(Homo
sapiens) 		3 / 3 VAL B 443
GLN B 397
CYH B 399
 None
 0.80A 5icxA-5c53B:
1.8
5icxE-5c53B:
undetectable		 5icxA-5c53B:
13.00
5icxE-5c53B:
1.65