SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICT_C_T44C128_1 (TRANSTHYRETIN)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	LEU A 216 LEU A 242 ALA A 223 LEU A 227 VAL A 219	None	1.04A	1ictA-5c54A: undetectable 1ictC-5c54A: undetectable	1ictA-5c54A: 18.57 1ictC-5c54A: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRQ_A_STRA501_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	LEU A 216 VAL A 253 ILE A 252 HIS A 34 LEU A 309	None GOL A 401 ( 4.8A) None None None	1.27A	1mrqA-5c54A: 11.7	1mrqA-5c54A: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_B_THAB2_1 (LIVER CARBOXYLESTERASE I)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	VAL A 305 LEU A 216 LEU A 249 LEU A 35 HIS A 34	None	1.42A	1mx1B-5c54A: undetectable	1mx1B-5c54A: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q6I_A_FK5A301_1 (FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 9	LEU A 135 VAL A 81 ILE A 82 ILE A 140 PHE A 44	None	1.29A	1q6iA-5c54A: undetectable	1q6iA-5c54A: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZR_B_CDXB901_1 (DNA TOPOISOMERASE II)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	4 / 7	HIS A 122 THR A 107 ASN A 147 LEU A 153	None	1.11A	1qzrA-5c54A: undetectable	1qzrA-5c54A: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZR_B_CDXB901_2 (DNA TOPOISOMERASE II)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	4 / 7	HIS A 122 THR A 107 ASN A 147 LEU A 153	None	1.05A	1qzrB-5c54A: undetectable	1qzrB-5c54A: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T6Z_A_RBFA296_1 (RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	THR A 78 VAL A 75 LEU A 194 ILE A 10 ASP A 41	None	1.29A	1t6zA-5c54A: undetectable	1t6zA-5c54A: 22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXC_A_P1ZA2001_1 (SERUM ALBUMIN)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	SER A 264 LEU A 35 LEU A 31 ALA A 63 ILE A 67	None	0.95A	2bxcA-5c54A: undetectable	2bxcA-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_NCAA493_0 (CHORISMATE SYNTHASE)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	THR A 107 ILE A 140 ARG A 60 ALA A 53 VAL A 144	None	1.20A	2qhfA-5c54A: undetectable	2qhfA-5c54A: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCD_A_RAPA138_1 (OUTER MEMBRANE PROTEIN MIP)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	PHE A 44 PHE A 110 VAL A 144 ILE A 140 PRO A 141	None	1.43A	2vcdA-5c54A: undetectable	2vcdA-5c54A: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_I_ASDI1224_1 (GLUTATHIONE S-TRANSFERASE A3)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 9	LEU A 148 LEU A 178 LEU A 154 ALA A 157 PHE A 191	None	1.18A	2vcvI-5c54A: undetectable	2vcvI-5c54A: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XPW_A_OTCA222_1 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 216 ASN A 247 PHE A 250 VAL A 201 GLN A 243	None	1.20A	2xpwA-5c54A: undetectable	2xpwA-5c54A: 24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB3_A_SAMA1101_0 (STRUCTURAL PROTEIN VP3)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	SER A 49 MET A 14 GLU A 198 VAL A 305 ILE A 252	GOL A 401 ( 3.7A) None GOL A 401 (-2.7A) None None	1.21A	3jb3A-5c54A: 1.3	3jb3A-5c54A: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O7W_A_SAMA801_0 (LEUCINE CARBOXYL METHYLTRANSFERASE 1)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	GLY A 267 GLY A 270 PHE A 250 ILE A 252 GLU A 51	GOL A 401 (-3.2A) None None None None	1.02A	3o7wA-5c54A: undetectable	3o7wA-5c54A: 25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 104 ALA A 101 LEU A 64 ILE A 82 GLY A 47	None	1.10A	3q95A-5c54A: undetectable	3q95A-5c54A: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3A_A_TACA222_1 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 216 ASN A 247 PHE A 250 VAL A 201 GLN A 243	None	1.22A	4b3aA-5c54A: undetectable	4b3aA-5c54A: 24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM4_A_8PRA603_1 (TRANSPORTER)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	VAL A 105 ALA A 106 TYR A 138 SER A 48 THR A 78	None	1.35A	4mm4A-5c54A: undetectable	4mm4A-5c54A: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OJB_A_198A1001_1 (ANDROGEN RECEPTOR)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 268 GLY A 267 LEU A 293 HIS A 260 THR A 258	None GOL A 401 (-3.2A) None None None	1.41A	4ojbA-5c54A: undetectable	4ojbA-5c54A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OK1_A_198A1001_1 (ANDROGEN RECEPTOR)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 153 LEU A 162 GLY A 164 LEU A 194 ILE A 179	None	1.15A	4ok1A-5c54A: undetectable	4ok1A-5c54A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKX_A_198A1002_1 (ANDROGEN RECEPTOR)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 268 GLY A 267 LEU A 293 HIS A 260 THR A 258	None GOL A 401 (-3.2A) None None None	1.39A	4okxA-5c54A: undetectable	4okxA-5c54A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.95A	4qvlK-5c54A: undetectable 4qvlL-5c54A: undetectable	4qvlK-5c54A: 23.23 4qvlL-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.96A	4qvlY-5c54A: undetectable 4qvlZ-5c54A: undetectable	4qvlY-5c54A: 23.23 4qvlZ-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 9	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.95A	4qvmK-5c54A: undetectable 4qvmL-5c54A: undetectable	4qvmK-5c54A: 23.23 4qvmL-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 10	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.95A	4qvmY-5c54A: undetectable 4qvmZ-5c54A: undetectable	4qvmY-5c54A: 23.23 4qvmZ-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 10	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.95A	4qvpK-5c54A: undetectable 4qvpL-5c54A: undetectable	4qvpK-5c54A: 23.23 4qvpL-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 10	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.96A	4qvpY-5c54A: undetectable 4qvpZ-5c54A: undetectable	4qvpY-5c54A: 23.23 4qvpZ-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.97A	4qw1K-5c54A: undetectable 4qw1L-5c54A: undetectable	4qw1K-5c54A: 23.55 4qw1L-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 10	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.97A	4qw1Y-5c54A: undetectable 4qw1Z-5c54A: undetectable	4qw1Y-5c54A: 23.55 4qw1Z-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 10	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.96A	4qw3K-5c54A: undetectable 4qw3L-5c54A: undetectable	4qw3K-5c54A: 23.23 4qw3L-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 10	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.96A	4qw3Y-5c54A: undetectable 4qw3Z-5c54A: undetectable	4qw3Y-5c54A: 23.23 4qw3Z-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVP_B_GBMB402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 216 VAL A 253 ILE A 252 HIS A 34 LEU A 309	None GOL A 401 ( 4.8A) None None None	1.27A	4yvpB-5c54A: 5.9	4yvpB-5c54A: 22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.96A	5bxnK-5c54A: undetectable 5bxnL-5c54A: undetectable	5bxnK-5c54A: 23.23 5bxnL-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 11	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.96A	5bxnY-5c54A: undetectable 5bxnZ-5c54A: undetectable	5bxnY-5c54A: 23.23 5bxnZ-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 9	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.96A	5d0xK-5c54A: undetectable 5d0xL-5c54A: undetectable	5d0xK-5c54A: 23.10 5d0xL-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 9	ALA A 79 THR A 78 ALA A 45 GLY A 100 ALA A 99	None	0.97A	5d0xY-5c54A: undetectable 5d0xZ-5c54A: undetectable	5d0xY-5c54A: 23.10 5d0xZ-5c54A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H5F_A_SAMA301_0 (PROTEIN ARGININE N-METHYLTRANSFERASE SFM1)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	5 / 12	LEU A 104 GLY A 42 ASP A 41 LEU A 133 ALA A 101	None	0.94A	5h5fA-5c54A: 2.7	5h5fA-5c54A: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPR_A_PAUA404_0 (PANTOTHENATE KINASE 3)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	4 / 5	GLU A 51 GLY A 269 SER A 264 GLY A 263	None	1.08A	5kprA-5c54A: undetectable	5kprA-5c54A: 22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZJ_A_TEPA2401_1 (ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	4 / 8	LEU A 104 GLU A 98 LEU A 64 ILE A 68	None	0.89A	5mzjA-5c54A: undetectable	5mzjA-5c54A: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_B_EY4B500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	4 / 6	VAL A 219 PRO A 12 ALA A 274 THR A 273	None	1.00A	6cduB-5c54A: undetectable 6cduC-5c54A: undetectable	6cduB-5c54A: 21.41 6cduC-5c54A: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_D_EY4D500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	5c54	DIHYDRODIPICOLINATE SYNTHASE/N-ACETYLNEU RAMINATE LYASE (Corynebacterium glutamicum)	4 / 7	VAL A 219 PRO A 12 ALA A 274 THR A 273	None	0.99A	6cduC-5c54A: undetectable 6cduD-5c54A: undetectable	6cduC-5c54A: 21.41 6cduD-5c54A: 21.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ICT_C_T44C128_1","TRANSTHYRETIN;TRANSTHYRETIN","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 216;LEU A 242;ALA A 223;LEU A 227;VAL A 219","None","1.04A","1ictA-5c54A:undetectable;1ictC-5c54A:undetectable","1ictA-5c54A:18.57;1ictC-5c54A:18.57"],["1MRQ_A_STRA501_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 216;VAL A 253;ILE A 252;HIS A  34;LEU A 309","None;GOL A 401 ( 4.8A);None;None;None","1.27A","1mrqA-5c54A:11.7","1mrqA-5c54A:22.51"],["1MX1_B_THAB2_1","LIVER CARBOXYLESTERASE I","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"VAL A 305;LEU A 216;LEU A 249;LEU A  35;HIS A  34","None","1.42A","1mx1B-5c54A:undetectable","1mx1B-5c54A:19.53"],["1Q6I_A_FK5A301_1","FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 135;VAL A  81;ILE A  82;ILE A 140;PHE A  44","None","1.29A","1q6iA-5c54A:undetectable","1q6iA-5c54A:22.26"],["1QZR_B_CDXB901_1","DNA TOPOISOMERASE II;DNA TOPOISOMERASE II","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",4,"HIS A 122;THR A 107;ASN A 147;LEU A 153","None","1.11A","1qzrA-5c54A:undetectable","1qzrA-5c54A:20.84"],["1QZR_B_CDXB901_2","DNA TOPOISOMERASE II","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",4,"HIS A 122;THR A 107;ASN A 147;LEU A 153","None","1.05A","1qzrB-5c54A:undetectable","1qzrB-5c54A:20.84"],["1T6Z_A_RBFA296_1","RIBOFLAVIN KINASE\/FMN ADENYLYLTRANSFERASE","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"THR A  78;VAL A  75;LEU A 194;ILE A  10;ASP A  41","None","1.29A","1t6zA-5c54A:undetectable","1t6zA-5c54A:22.61"],["2BXC_A_P1ZA2001_1","SERUM ALBUMIN","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"SER A 264;LEU A  35;LEU A  31;ALA A  63;ILE A  67","None","0.95A","2bxcA-5c54A:undetectable","2bxcA-5c54A:19.56"],["2QHF_A_NCAA493_0","CHORISMATE SYNTHASE","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"THR A 107;ILE A 140;ARG A  60;ALA A  53;VAL A 144","None","1.20A","2qhfA-5c54A:undetectable","2qhfA-5c54A:24.18"],["2VCD_A_RAPA138_1","OUTER MEMBRANE PROTEIN MIP","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"PHE A  44;PHE A 110;VAL A 144;ILE A 140;PRO A 141","None","1.43A","2vcdA-5c54A:undetectable","2vcdA-5c54A:19.22"],["2VCV_I_ASDI1224_1","GLUTATHIONE S-TRANSFERASE A3","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 148;LEU A 178;LEU A 154;ALA A 157;PHE A 191","None","1.18A","2vcvI-5c54A:undetectable","2vcvI-5c54A:21.20"],["2XPW_A_OTCA222_1","TETRACYCLINE REPRESSOR PROTEIN CLASS D","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 216;ASN A 247;PHE A 250;VAL A 201;GLN A 243","None","1.20A","2xpwA-5c54A:undetectable","2xpwA-5c54A:24.84"],["3JB3_A_SAMA1101_0","STRUCTURAL PROTEIN VP3","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"SER A  49;MET A  14;GLU A 198;VAL A 305;ILE A 252","GOL A 401 ( 3.7A);None;GOL A 401 (-2.7A);None;None","1.21A","3jb3A-5c54A:1.3","3jb3A-5c54A:14.42"],["3O7W_A_SAMA801_0","LEUCINE CARBOXYL METHYLTRANSFERASE 1","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"GLY A 267;GLY A 270;PHE A 250;ILE A 252;GLU A  51","GOL A 401 (-3.2A);None;None;None;None","1.02A","3o7wA-5c54A:undetectable","3o7wA-5c54A:25.07"],["3Q95_A_ESLA700_1","ESTROGEN RECEPTOR","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 104;ALA A 101;LEU A  64;ILE A  82;GLY A  47","None","1.10A","3q95A-5c54A:undetectable","3q95A-5c54A:22.96"],["4B3A_A_TACA222_1","TETRACYCLINE REPRESSOR PROTEIN CLASS D","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 216;ASN A 247;PHE A 250;VAL A 201;GLN A 243","None","1.22A","4b3aA-5c54A:undetectable","4b3aA-5c54A:24.84"],["4MM4_A_8PRA603_1","TRANSPORTER","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"VAL A 105;ALA A 106;TYR A 138;SER A  48;THR A  78","None","1.35A","4mm4A-5c54A:undetectable","4mm4A-5c54A:22.99"],["4OJB_A_198A1001_1","ANDROGEN RECEPTOR","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 268;GLY A 267;LEU A 293;HIS A 260;THR A 258","None;GOL A 401 (-3.2A);None;None;None","1.41A","4ojbA-5c54A:undetectable","4ojbA-5c54A:21.98"],["4OK1_A_198A1001_1","ANDROGEN RECEPTOR","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 153;LEU A 162;GLY A 164;LEU A 194;ILE A 179","None","1.15A","4ok1A-5c54A:undetectable","4ok1A-5c54A:21.98"],["4OKX_A_198A1002_1","ANDROGEN RECEPTOR","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 268;GLY A 267;LEU A 293;HIS A 260;THR A 258","None;GOL A 401 (-3.2A);None;None;None","1.39A","4okxA-5c54A:undetectable","4okxA-5c54A:21.98"],["4QVL_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.95A","4qvlK-5c54A:undetectable;4qvlL-5c54A:undetectable","4qvlK-5c54A:23.23;4qvlL-5c54A:19.56"],["4QVL_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.96A","4qvlY-5c54A:undetectable;4qvlZ-5c54A:undetectable","4qvlY-5c54A:23.23;4qvlZ-5c54A:19.56"],["4QVM_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.95A","4qvmK-5c54A:undetectable;4qvmL-5c54A:undetectable","4qvmK-5c54A:23.23;4qvmL-5c54A:19.56"],["4QVM_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.95A","4qvmY-5c54A:undetectable;4qvmZ-5c54A:undetectable","4qvmY-5c54A:23.23;4qvmZ-5c54A:19.56"],["4QVP_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.95A","4qvpK-5c54A:undetectable;4qvpL-5c54A:undetectable","4qvpK-5c54A:23.23;4qvpL-5c54A:19.56"],["4QVP_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.96A","4qvpY-5c54A:undetectable;4qvpZ-5c54A:undetectable","4qvpY-5c54A:23.23;4qvpZ-5c54A:19.56"],["4QW1_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.97A","4qw1K-5c54A:undetectable;4qw1L-5c54A:undetectable","4qw1K-5c54A:23.55;4qw1L-5c54A:19.56"],["4QW1_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.97A","4qw1Y-5c54A:undetectable;4qw1Z-5c54A:undetectable","4qw1Y-5c54A:23.55;4qw1Z-5c54A:19.56"],["4QW3_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.96A","4qw3K-5c54A:undetectable;4qw3L-5c54A:undetectable","4qw3K-5c54A:23.23;4qw3L-5c54A:19.56"],["4QW3_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.96A","4qw3Y-5c54A:undetectable;4qw3Z-5c54A:undetectable","4qw3Y-5c54A:23.23;4qw3Z-5c54A:19.56"],["4YVP_B_GBMB402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 216;VAL A 253;ILE A 252;HIS A  34;LEU A 309","None;GOL A 401 ( 4.8A);None;None;None","1.27A","4yvpB-5c54A:5.9","4yvpB-5c54A:22.79"],["5BXN_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.96A","5bxnK-5c54A:undetectable;5bxnL-5c54A:undetectable","5bxnK-5c54A:23.23;5bxnL-5c54A:19.56"],["5BXN_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.96A","5bxnY-5c54A:undetectable;5bxnZ-5c54A:undetectable","5bxnY-5c54A:23.23;5bxnZ-5c54A:19.56"],["5D0X_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.96A","5d0xK-5c54A:undetectable;5d0xL-5c54A:undetectable","5d0xK-5c54A:23.10;5d0xL-5c54A:19.56"],["5D0X_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"ALA A  79;THR A  78;ALA A  45;GLY A 100;ALA A  99","None","0.97A","5d0xY-5c54A:undetectable;5d0xZ-5c54A:undetectable","5d0xY-5c54A:23.10;5d0xZ-5c54A:19.56"],["5H5F_A_SAMA301_0","PROTEIN ARGININE N-METHYLTRANSFERASE SFM1","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",5,"LEU A 104;GLY A  42;ASP A  41;LEU A 133;ALA A 101","None","0.94A","5h5fA-5c54A:2.7","5h5fA-5c54A:21.32"],["5KPR_A_PAUA404_0","PANTOTHENATE KINASE 3","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",4,"GLU A  51;GLY A 269;SER A 264;GLY A 263","None","1.08A","5kprA-5c54A:undetectable","5kprA-5c54A:22.98"],["5MZJ_A_TEPA2401_1","ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",4,"LEU A 104;GLU A  98;LEU A  64;ILE A  68","None","0.89A","5mzjA-5c54A:undetectable","5mzjA-5c54A:22.25"],["6CDU_B_EY4B500_0","CHIMERIC ALPHA1GABAA RECEPTOR","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",4,"VAL A 219;PRO A  12;ALA A 274;THR A 273","None","1.00A","6cduB-5c54A:undetectable;6cduC-5c54A:undetectable","6cduB-5c54A:21.41;6cduC-5c54A:21.41"],["6CDU_D_EY4D500_0","CHIMERIC ALPHA1GABAA RECEPTOR","5c54","DIHYDRODIPICOLINATE SYNTHASE\/N-ACETYLNEURAMINATE LYASE","Corynebacterium glutamicum",4,"VAL A 219;PRO A  12;ALA A 274;THR A 273","None","0.99A","6cduC-5c54A:undetectable;6cduD-5c54A:undetectable","6cduC-5c54A:21.41;6cduD-5c54A:21.41"]]