SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 6 VAL A 130
GLY A 131
ALA A  73
LEU A 158
 None
 0.77A 1e7bB-5c59A:
undetectable		 1e7bB-5c59A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.85A 1jnoA-5c59A:
undetectable		 1jnoA-5c59A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.85A 1jnoB-5c59A:
undetectable		 1jnoB-5c59A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.91A 1jo3A-5c59A:
undetectable		 1jo3A-5c59A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.91A 1jo3B-5c59A:
undetectable		 1jo3B-5c59A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.90A 1jo4A-5c59A:
undetectable		 1jo4A-5c59A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.90A 1jo4B-5c59A:
undetectable		 1jo4B-5c59A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 7 LEU A 173
THR A 177
MET A 211
GLN A  96
 None
 1.25A 1kglA-5c59A:
undetectable		 1kglA-5c59A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.85A 1ng8A-5c59A:
undetectable		 1ng8A-5c59A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.85A 1ng8B-5c59A:
undetectable		 1ng8B-5c59A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.91A 1nrmA-5c59A:
undetectable		 1nrmA-5c59A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.91A 1nrmB-5c59A:
undetectable		 1nrmB-5c59A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.83A 1nruA-5c59A:
undetectable		 1nruA-5c59A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  52
VAL A 180
TRP A  48
 None
 0.83A 1nruB-5c59A:
undetectable		 1nruB-5c59A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 6 PHE A  81
VAL A 156
LEU A 108
ALA A 141
 None
 1.08A 2e1qA-5c59A:
2.1		 2e1qA-5c59A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 GLY A  75
THR A  53
THR A 177
PHE A  94
GLY A  78
 None
 1.49A 3ag4A-5c59A:
undetectable
3ag4B-5c59A:
undetectable
3ag4T-5c59A:
undetectable		 3ag4A-5c59A:
17.69
3ag4B-5c59A:
22.93
3ag4T-5c59A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ALA A  70
VAL A  69
GLN A 115
 None
 0.71A 3of4B-5c59A:
2.1		 3of4B-5c59A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 5 ARG A 179
THR A  15
THR A 177
ASP A  17
 None
 1.41A 4oltA-5c59A:
undetectable		 4oltA-5c59A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 5 ARG A 179
THR A  15
THR A 177
ASP A  17
 None
 1.39A 4oltB-5c59A:
undetectable		 4oltB-5c59A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 5 ARG A 179
THR A  15
THR A 177
ASP A  17
 None
 1.38A 4qwpA-5c59A:
undetectable		 4qwpA-5c59A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 5 ARG A 179
THR A  15
THR A 177
ASP A  17
 None
 1.34A 4qwpB-5c59A:
undetectable		 4qwpB-5c59A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		3 / 3 ASP A 205
HIS A 201
LYS A 204
 None
 0.93A 4qzuD-5c59A:
undetectable		 4qzuD-5c59A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		5 / 12 LEU A  40
TYR A  37
SER A 175
SER A  51
ASN A 174
 None
 1.23A 4yvxA-5c59A:
undetectable		 4yvxA-5c59A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB
(Escherichia
coli) 		4 / 5 SER A  77
VAL A  76
ASN A 174
PRO A  54
 None
 1.41A 6fi4A-5c59A:
undetectable
6fi4B-5c59A:
undetectable		 6fi4A-5c59A:
22.61
6fi4B-5c59A:
3.38