SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		5 / 9 LEU A 185
VAL A  25
GLY A  24
ALA B  74
LEU B  75
 None
 1.14A 1e7bA-5c5bA:
undetectable		 1e7bA-5c5bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		5 / 9 LEU B  40
GLU A  69
ILE A  93
VAL B  47
MET B  44
 None
 1.09A 1gx8A-5c5bB:
undetectable		 1gx8A-5c5bB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		4 / 7 LEU B  40
MET B 196
LEU A  86
GLU A  69
 None
 1.00A 1linA-5c5bB:
undetectable		 1linA-5c5bB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		4 / 4 HIS B 205
ALA B 204
PHE B 203
GLY B 202
 None
 1.27A 1mjoD-5c5bB:
undetectable		 1mjoD-5c5bB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		5 / 12 ALA B 136
GLY B 134
ALA B 170
ARG B 171
SER B 177
 None
 1.10A 1ve3A-5c5bB:
undetectable		 1ve3A-5c5bB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
(Homo
sapiens) 		6 / 12 PHE A  89
GLY A 230
ASP A  94
ILE A  93
LEU A  65
VAL A 233
 None
 1.44A 2hmyB-5c5bA:
undetectable		 2hmyB-5c5bA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
(Homo
sapiens) 		4 / 6 LEU A 277
SER A 359
ASP A 265
GLU A 365
 None
 1.26A 2vn1B-5c5bA:
undetectable		 2vn1B-5c5bA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		5 / 12 MET A 111
LEU B  61
LEU A 107
ILE A  47
LEU B  96
 None
 1.23A 3a50E-5c5bA:
undetectable		 3a50E-5c5bA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU A 155
ASP A 157
ASP B 265
 None
 0.62A 3jb2A-5c5bA:
undetectable		 3jb2A-5c5bA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU A  40
TYR A 203
PHE B  89
LEU B  65
TYR A  36
 None
 1.30A 3m8pA-5c5bA:
2.3
3m8pB-5c5bA:
undetectable		 3m8pA-5c5bA:
20.11
3m8pB-5c5bA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A  40
TYR A 203
PHE B  89
LEU B  65
TYR A  36
 None
 1.26A 3mecA-5c5bA:
undetectable		 3mecA-5c5bA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A  40
TYR A 203
PHE B  89
LEU B  65
TYR A  36
 None
 1.33A 3medA-5c5bA:
undetectable
3medB-5c5bA:
undetectable		 3medA-5c5bA:
20.11
3medB-5c5bA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		5 / 12 LEU A  96
HIS A 100
THR A  58
LEU A  54
PHE B 203
 None
 1.21A 3n58A-5c5bA:
undetectable		 3n58A-5c5bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		5 / 11 SER B 178
GLN B  18
LEU B  23
TYR B 182
GLN B  14
 None
 1.30A 3zqeA-5c5bB:
5.5
3zqeB-5c5bB:
3.1		 3zqeA-5c5bB:
22.22
3zqeB-5c5bB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		4 / 6 TYR B  88
HIS B  87
VAL B  82
PHE B 225
 None
 1.19A 4a97E-5c5bB:
5.3		 4a97E-5c5bB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		4 / 6 GLU B 102
ASN B 209
HIS A 100
VAL B  47
 None
 0.89A 4ejwB-5c5bB:
0.9		 4ejwB-5c5bB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B 299
HIS A 140
TYR B 283
 None
 1.12A 4fu8A-5c5bB:
undetectable		 4fu8A-5c5bB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		4 / 6 SER B 137
GLN B 174
THR B  19
ARG B  20
 None
 1.32A 4lnxA-5c5bB:
undetectable		 4lnxA-5c5bB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 287
TRP A 297
ILE A 354
 None
 0.83A 4mwxA-5c5bA:
undetectable		 4mwxA-5c5bA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		3 / 3 ARG B 287
TRP B 297
ILE B 354
 None
 0.72A 4mwxA-5c5bB:
undetectable		 4mwxA-5c5bB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		4 / 6 ARG B  46
ALA B  50
LEU A  54
SER A  97
 None
 1.08A 4ot2A-5c5bB:
3.0		 4ot2A-5c5bB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		5 / 12 ASP B 122
LEU B 123
LEU B  33
ARG B 191
MET A  82
 None
 1.14A 4x1gA-5c5bB:
undetectable		 4x1gA-5c5bB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens) 		3 / 3 GLY B 202
VAL B  47
MET B  44
 None
 0.53A 5ycpA-5c5bB:
undetectable		 5ycpA-5c5bB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
(Homo
sapiens) 		4 / 4 ASP A  15
ALA A 142
SER A 170
PHE A 133
 None
 1.46A 6cm4A-5c5bA:
4.3		 6cm4A-5c5bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASP A  49
HIS B 100
ARG A  46
HIS A  45
 None
 1.13A 6mn4A-5c5bA:
undetectable		 6mn4A-5c5bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASP A  49
HIS B 100
ARG A  46
HIS A  45
 None
 1.22A 6mn4B-5c5bA:
undetectable		 6mn4B-5c5bA:
21.47