SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 11 PRO A  68
LEU A  64
TYR A 108
GLY A 125
LEU A 115
 None
EDO  A 402 ( 4.1A)
None
None
None
 1.44A 1fkpA-5c5gA:
undetectable		 1fkpA-5c5gA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 12 TYR A 198
VAL A  60
SER A 217
VAL A 271
LEU A 264
 None
 1.36A 2hc4A-5c5gA:
undetectable		 2hc4A-5c5gA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 9 GLY A 194
THR A 129
VAL A 187
ILE A 143
VAL A 139
 None
 1.31A 2nnhB-5c5gA:
undetectable		 2nnhB-5c5gA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 12 GLY A 162
ASP A 196
VAL A 199
GLY A 192
ILE A 143
 None
 0.86A 3ku1C-5c5gA:
undetectable		 3ku1C-5c5gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 11 LEU A 236
ILE A 206
ALA A 250
ALA A 223
ALA A 205
 None
 1.13A 3mdtB-5c5gA:
undetectable		 3mdtB-5c5gA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		4 / 5 GLY A  95
PRO A  94
ASN A  93
TYR A 146
 None
 1.20A 3u8qA-5c5gA:
undetectable		 3u8qA-5c5gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 12 TYR A 131
ALA A 128
ASN A 202
ASN A  93
GLY A  97
 None
None
EDO  A 401 (-3.3A)
None
None
 1.04A 4obwD-5c5gA:
undetectable		 4obwD-5c5gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 12 PHE A 221
ILE A 278
ALA A 275
PHE A 237
VAL A 271
 None
 1.08A 4u8vB-5c5gA:
undetectable		 4u8vB-5c5gA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		5 / 12 PHE A 221
ILE A 278
ALA A 275
PHE A 237
VAL A 271
 None
 1.08A 4u8yB-5c5gA:
undetectable		 4u8yB-5c5gA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5c5g SPHERULIN-4
(Aspergillus
clavatus) 		4 / 5 TYR A 146
GLY A  95
TYR A 108
GLY A 106
 None
 0.96A 5ayfA-5c5gA:
undetectable		 5ayfA-5c5gA:
21.20