SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		5 / 12 GLY A 270
VAL A 305
LEU A 307
LEU A 293
MET A 340
 4YB  A 502 (-4.4A)
None
None
None
None
 1.25A 1mx1C-5c5hA:
undetectable		 1mx1C-5c5hA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 6 ASN A  61
TRP A  60
HIS A 186
GLY A 189
 None
 1.49A 1mxdA-5c5hA:
undetectable		 1mxdA-5c5hA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 4 VAL A 105
ALA A 103
LEU A  95
PHE A 112
 None
 1.26A 1q97B-5c5hA:
undetectable		 1q97B-5c5hA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 8 TYR A 156
TRP A 194
LEU A 184
MET A 193
 None
 1.19A 1uw6A-5c5hA:
undetectable
1uw6B-5c5hA:
undetectable		 1uw6A-5c5hA:
18.20
1uw6B-5c5hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 8 TYR A 156
TRP A 194
LEU A 184
MET A 193
 None
 1.18A 1uw6D-5c5hA:
undetectable
1uw6E-5c5hA:
undetectable		 1uw6D-5c5hA:
18.20
1uw6E-5c5hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 8 TYR A 156
TRP A 194
LEU A 184
MET A 193
 None
 1.23A 1uw6G-5c5hA:
undetectable
1uw6H-5c5hA:
undetectable		 1uw6G-5c5hA:
18.20
1uw6H-5c5hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 8 TYR A 156
TRP A 194
LEU A 184
MET A 193
 None
 1.21A 1uw6P-5c5hA:
undetectable
1uw6Q-5c5hA:
undetectable		 1uw6P-5c5hA:
18.20
1uw6Q-5c5hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 8 LEU A 184
MET A 193
TYR A 156
TRP A 194
 None
 1.20A 1uw6P-5c5hA:
undetectable
1uw6T-5c5hA:
undetectable		 1uw6P-5c5hA:
18.20
1uw6T-5c5hA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		5 / 10 THR A 334
LEU A 271
VAL A 278
GLY A 270
VAL A 289
 None
4YB  A 502 (-4.3A)
None
4YB  A 502 (-4.4A)
None
 1.36A 2cp4A-5c5hA:
undetectable		 2cp4A-5c5hA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		5 / 12 ALA A 249
GLY A 247
GLY A 270
THR A 226
VAL A 224
 4YB  A 502 (-4.1A)
4YB  A 502 (-3.6A)
4YB  A 502 (-4.4A)
None
4YB  A 502 ( 4.8A)
 0.96A 2okcA-5c5hA:
undetectable		 2okcA-5c5hA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		3 / 3 SER A 276
HIS A 220
ASP A 174
 4YB  A 502 (-3.9A)
None
None
 0.82A 2oxtA-5c5hA:
2.3		 2oxtA-5c5hA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 6 LEU A  73
TRP A 196
MET A 203
LEU A 180
 None
 1.46A 2oz7A-5c5hA:
undetectable		 2oz7A-5c5hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		3 / 3 TRP A  30
GLN A  27
TRP A 178
 None
 1.02A 2vqyA-5c5hA:
undetectable		 2vqyA-5c5hA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 7 GLN A 227
LEU A 231
LEU A 215
LEU A 211
 None
 0.87A 3bgdB-5c5hA:
undetectable		 3bgdB-5c5hA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		4 / 8 TYR A 156
TRP A 194
LEU A 184
MET A 193
 None
 1.28A 3wipG-5c5hA:
undetectable
3wipH-5c5hA:
undetectable		 3wipG-5c5hA:
19.51
3wipH-5c5hA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		5 / 12 ARG A   9
GLY A  43
VAL A 123
GLU A  39
VAL A  46
 MG  A 501 (-4.5A)
None
None
None
None
 1.26A 4danA-5c5hA:
undetectable
4danB-5c5hA:
undetectable		 4danA-5c5hA:
18.85
4danB-5c5hA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		6 / 12 ARG A 337
LEU A 345
TYR A 269
VAL A 348
GLY A 338
LEU A 351
 None
 1.49A 5ikqB-5c5hA:
undetectable		 5ikqB-5c5hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5c5h 2-SUCCINYLBENZOATE--
COA LIGASE
(Escherichia
coli) 		5 / 12 PRO A 364
VAL A 367
ILE A 371
ALA A 372
ILE A 362
 None
 0.79A 5j2tC-5c5hA:
undetectable		 5j2tC-5c5hA:
21.37