SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.17A 1jffB-5c5sA:
undetectable		 1jffB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 11 GLU A 136
ARG A 243
LEU A 139
GLU A 143
HIS A 145
 None
 1.34A 1mjlA-5c5sA:
undetectable
1mjlB-5c5sA:
undetectable		 1mjlA-5c5sA:
21.62
1mjlB-5c5sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		4 / 7 ARG A 305
GLU A 297
PRO A 262
ALA A 252
 None
 1.06A 2ejgA-5c5sA:
undetectable		 2ejgA-5c5sA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.17A 2hxfB-5c5sA:
undetectable		 2hxfB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.17A 2hxhB-5c5sA:
undetectable		 2hxhB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.17A 2p4nB-5c5sA:
undetectable		 2p4nB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.17A 2wbeB-5c5sA:
undetectable		 2wbeB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.16A 3dcoB-5c5sA:
undetectable		 3dcoB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.15A 3edlB-5c5sA:
undetectable		 3edlB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.15A 3iz0B-5c5sA:
undetectable		 3iz0B-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		3 / 3 GLU A 235
ASP A 122
ASP A 127
 None
 0.60A 3jb2A-5c5sA:
undetectable		 3jb2A-5c5sA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		4 / 8 TYR A 207
LEU A 211
VAL A 214
GLU A 215
 None
 0.46A 4fgzB-5c5sA:
undetectable		 4fgzB-5c5sA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		4 / 6 PHE A 246
LYS A 250
LEU A 253
ARG A 243
 None
 1.38A 4yv5B-5c5sA:
undetectable		 4yv5B-5c5sA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 9 LEU A 233
THR A 203
LEU A 201
PRO A 198
LEU A 197
 None
 1.44A 5g48B-5c5sA:
undetectable		 5g48B-5c5sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.12A 5hnwB-5c5sA:
undetectable		 5hnwB-5c5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 VAL A 251
LEU A 135
HIS A 247
PHE A 269
LEU A 194
 None
 1.15A 5hnyB-5c5sA:
undetectable		 5hnyB-5c5sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		4 / 7 THR A 284
ASP A 288
TYR A 207
GLY A 208
 None
 1.03A 5hwaA-5c5sA:
undetectable		 5hwaA-5c5sA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 LEU A 194
LEU A 135
ILE A 245
LEU A 273
LEU A 233
 None
 1.17A 5og9B-5c5sA:
undetectable		 5og9B-5c5sA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens) 		5 / 12 GLU A 215
LEU A 241
LEU A 299
LEU A 230
GLY A 208
 None
 0.98A 6b0cD-5c5sA:
undetectable		 6b0cD-5c5sA:
13.79