SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 TRP A 201
VAL A 295
TRP A 402
 None
 1.29A 1c4dC-5c5vA:
undetectable
1c4dD-5c5vA:
undetectable		 1c4dC-5c5vA:
3.46
1c4dD-5c5vA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 TRP A 402
VAL A 295
TRP A 201
 None
 1.31A 1c4dC-5c5vA:
undetectable
1c4dD-5c5vA:
undetectable		 1c4dC-5c5vA:
3.46
1c4dD-5c5vA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 VAL A 295
TRP A 402
TRP A 201
 None
 1.21A 2xdcC-5c5vA:
undetectable
2xdcD-5c5vA:
undetectable		 2xdcC-5c5vA:
3.46
2xdcD-5c5vA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 5 ASP A 291
ARG A 259
LYS A 237
ASP A 328
 MG  A 503 ( 2.7A)
2PN  A 501 ( 2.9A)
2PN  A 501 (-2.7A)
MG  A 503 (-2.3A)
 1.36A 3kd5E-5c5vA:
0.0		 3kd5E-5c5vA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 MET A 120
VAL A 101
PHE A 136
GLU A 123
 None
 1.29A 3ufpA-5c5vA:
undetectable
3ufpB-5c5vA:
2.7		 3ufpA-5c5vA:
20.84
3ufpB-5c5vA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 MET A 120
VAL A 101
PHE A 136
GLU A 123
 None
 1.34A 4caoA-5c5vA:
undetectable
4caoB-5c5vA:
undetectable		 4caoA-5c5vA:
20.84
4caoB-5c5vA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 HIS A 348
ASP A 346
PRO A 351
VAL A 332
 None
 0.98A 4hvrA-5c5vA:
undetectable		 4hvrA-5c5vA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		3 / 3 PRO A 274
VAL A 313
HIS A 336
 None
 0.69A 4pevC-5c5vA:
undetectable		 4pevC-5c5vA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 6 LYS A 237
ARG A 259
ASP A 296
ASP A 328
 2PN  A 501 (-2.7A)
2PN  A 501 ( 2.9A)
MG  A 505 (-2.3A)
MG  A 503 (-2.3A)
 1.35A 5hp1C-5c5vA:
undetectable		 5hp1C-5c5vA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 PHE A 136
GLU A 123
MET A 120
VAL A 101
 None
 1.16A 5vusA-5c5vA:
3.2
5vusB-5c5vA:
undetectable		 5vusA-5c5vA:
20.84
5vusB-5c5vA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
brucei) 		4 / 7 MET A 120
VAL A 101
PHE A 136
GLU A 123
 None
 1.21A 5vuyA-5c5vA:
2.8
5vuyB-5c5vA:
undetectable		 5vuyA-5c5vA:
20.78
5vuyB-5c5vA:
20.78