SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 SER A 189
HIS A 173
ALA A 143
ILE A 146
ILE A  72
 None
 0.84A 2bxcA-5c5xA:
undetectable		 2bxcA-5c5xA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 VAL A  91
ALA A 187
SER A 183
THR A 139
ALA A  71
 None
 1.30A 2qm9A-5c5xA:
undetectable		 2qm9A-5c5xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		4 / 7 GLU A 135
GLY A 181
PHE A  49
PHE A  24
 None
 0.98A 2qmzA-5c5xA:
undetectable
2qmzB-5c5xA:
undetectable		 2qmzA-5c5xA:
23.57
2qmzB-5c5xA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		6 / 10 PHE A  27
GLY A  97
GLY A  28
LEU A  29
LEU A 105
ALA A 102
 None
 1.27A 2v3kA-5c5xA:
undetectable		 2v3kA-5c5xA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		3 / 3 ILE A  53
SER A 168
SER A 164
 None
 0.51A 3iltH-5c5xA:
undetectable		 3iltH-5c5xA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 9 LEU A  47
PHE A  24
GLY A  30
ALA A  32
ILE A 177
 None
 1.13A 3jusB-5c5xA:
undetectable		 3jusB-5c5xA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 LEU A  22
ILE A  99
GLY A 103
ALA A 102
LEU A  29
 None
 1.01A 3n8xA-5c5xA:
undetectable		 3n8xA-5c5xA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		3 / 3 THR A 180
ASN A 120
GLU A 135
 None
 0.77A 3v4tA-5c5xA:
undetectable
3v4tC-5c5xA:
undetectable		 3v4tA-5c5xA:
23.47
3v4tC-5c5xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 LEU A  29
ASN A 120
ALA A 193
VAL A 195
ALA A 102
 None
 1.16A 4x1kD-5c5xA:
undetectable		 4x1kD-5c5xA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 GLY A 166
LEU A  56
HIS A 173
LEU A 171
GLY A  66
 None
 0.99A 5d4uA-5c5xA:
undetectable		 5d4uA-5c5xA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 GLY A 166
LEU A  56
HIS A 173
LEU A 171
GLY A  66
 None
 1.01A 5d4uB-5c5xA:
undetectable		 5d4uB-5c5xA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 GLY A 166
LEU A  56
HIS A 173
LEU A 171
GLY A  66
 None
 1.00A 5d4uC-5c5xA:
undetectable		 5d4uC-5c5xA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 12 GLY A 166
LEU A  56
HIS A 173
LEU A 171
GLY A  66
 None
 0.95A 5d4uD-5c5xA:
undetectable		 5d4uD-5c5xA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		5 / 10 LEU A  56
ILE A  68
GLY A  66
LEU A  19
ALA A  20
 None
 1.05A 5o96C-5c5xA:
undetectable
5o96D-5c5xA:
undetectable		 5o96C-5c5xA:
20.83
5o96D-5c5xA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5c5x AQUAPORIN-5
(Homo
sapiens) 		4 / 5 PRO A  70
GLU A  17
ARG A  86
THR A  73
 None
 1.36A 5uxcA-5c5xA:
undetectable		 5uxcA-5c5xA:
24.51