SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		4 / 7 ALA A   8
SER A 236
SER A 240
THR A 244
 None
 1.02A 1dvxA-5c5yA:
undetectable		 1dvxA-5c5yA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		4 / 5 ASP A 102
GLY A 196
PRO A 199
ALA A 200
 UNL  A 301 ( 4.9A)
None
None
UNL  A 301 ( 4.2A)
 0.95A 2aofA-5c5yA:
undetectable		 2aofA-5c5yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 12 SER A 154
ILE A 139
ILE A 165
PHE A 197
GLU A 148
 None
 1.19A 2j0dA-5c5yA:
undetectable		 2j0dA-5c5yA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 12 ALA A  11
LEU A  12
ALA A   8
THR A 244
ILE A 239
 None
 1.17A 2jjpA-5c5yA:
undetectable		 2jjpA-5c5yA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		3 / 3 TYR A 212
VAL A 203
THR A 177
 None
 0.90A 2ygnA-5c5yA:
undetectable		 2ygnA-5c5yA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 12 ILE A  53
ALA A  71
LEU A  20
PRO A  77
ARG A  51
 None
None
UNL  A 301 ( 4.9A)
None
None
 1.20A 4gh8B-5c5yA:
undetectable		 4gh8B-5c5yA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 11 GLY A  97
ALA A  98
ASP A  99
ILE A  29
THR A  74
 None
None
GOL  A 302 ( 4.8A)
None
None
 1.13A 4l1aA-5c5yA:
undetectable		 4l1aA-5c5yA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 11 GLY A  97
ALA A  98
ILE A  29
THR A  74
VAL A 101
 None
 1.10A 4l1aA-5c5yA:
undetectable		 4l1aA-5c5yA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 12 VAL A 137
GLY A 161
ALA A 160
ILE A 156
PRO A 106
 None
GOL  A 303 ( 3.8A)
None
None
None
 0.91A 4xdrA-5c5yA:
undetectable		 4xdrA-5c5yA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 12 ASN A 175
PHE A  76
ILE A 165
PHE A 164
MET A 184
 None
 1.23A 5igyA-5c5yA:
undetectable		 5igyA-5c5yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 12 ILE A 165
GLY A 196
GLU A 147
ALA A 200
ILE A 219
 None
None
None
UNL  A 301 ( 4.2A)
None
 1.04A 5igyA-5c5yA:
undetectable		 5igyA-5c5yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		4 / 8 PRO A 178
TYR A 212
VAL A 203
GLY A 202
 None
 1.02A 5nzyA-5c5yA:
2.1		 5nzyA-5c5yA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A 161
LEU A 103
VAL A 137
LEU A  87
ASP A 120
 GOL  A 303 ( 3.8A)
None
None
None
None
 1.15A 5w7pA-5c5yA:
undetectable		 5w7pA-5c5yA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Colwellia
psychrerythraea) 		5 / 9 ILE A 165
GLU A 100
VAL A 195
ILE A 158
MET A 121
 None
None
GOL  A 303 ( 4.9A)
None
None
 1.39A 6hloA-5c5yA:
undetectable		 6hloA-5c5yA:
18.43