SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 8 SER A 146
ARG A 151
PHE A 154
GLY A 152
None
0.87A 1fapB-5c65A:
2.1
1fapB-5c65A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 4 THR A 156
LEU A 160
LEU A 167
GLN A 170
None
1.03A 1fbmA-5c65A:
undetectable
1fbmA-5c65A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 4 THR A 156
LEU A 160
VAL A 163
LEU A 167
None
0.73A 1mz9D-5c65A:
undetectable
1mz9D-5c65A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
5 / 12 ILE A  14
ALA A  17
LEU A 229
ILE A 225
PHE A 154
None
1.26A 1y0xX-5c65A:
undetectable
1y0xX-5c65A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
5 / 12 LEU A 276
LEU A 339
ILE A 285
GLY A 284
LEU A 282
None
1.24A 2j7xA-5c65A:
undetectable
2j7xA-5c65A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 8 GLU A 391
ILE A 388
ILE A 384
GLU A 452
None
0.90A 2j9dJ-5c65A:
undetectable
2j9dK-5c65A:
undetectable
2j9dL-5c65A:
undetectable
2j9dJ-5c65A:
13.51
2j9dK-5c65A:
13.51
2j9dL-5c65A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 6 PHE A 414
GLN A 281
ASN A 409
LEU A 439
None
1.26A 2nyrA-5c65A:
undetectable
2nyrA-5c65A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 5 VAL A 320
THR A 319
VAL A 163
GLY A 161
None
1.00A 2p2fA-5c65A:
undetectable
2p2fA-5c65A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 4 VAL A 320
THR A 319
VAL A 163
GLY A 161
None
0.98A 2p2fB-5c65A:
undetectable
2p2fB-5c65A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
3 / 3 GLU A 252
GLN A 395
ARG A 398
None
0.97A 2w3bB-5c65A:
undetectable
2w3bB-5c65A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 4 ARG A 248
GLY A 396
GLU A 252
SER A 208
None
1.11A 2xctS-5c65A:
undetectable
2xctU-5c65A:
undetectable
2xctS-5c65A:
20.58
2xctU-5c65A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 7 GLY A 161
ILE A 166
THR A  28
GLN A 159
None
0.98A 2xrhA-5c65A:
undetectable
2xrhA-5c65A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 7 ILE A 388
PHE A 387
ARG A 454
THR A 333
None
0.98A 3ag2N-5c65A:
undetectable
3ag2W-5c65A:
undetectable
3ag2N-5c65A:
24.43
3ag2W-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 7 ILE A 388
PHE A 387
ARG A 454
THR A 333
None
0.95A 3ag4N-5c65A:
undetectable
3ag4W-5c65A:
undetectable
3ag4N-5c65A:
24.43
3ag4W-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 4 GLY A  77
GLY A  74
GLY A 128
GLY A 132
None
0.64A 3bogD-5c65A:
undetectable
3bogD-5c65A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
5 / 12 LEU A 133
VAL A  72
GLY A  73
GLY A  77
PHE A 130
None
1.36A 3dh0A-5c65A:
undetectable
3dh0A-5c65A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 8 PHE A 393
GLU A 252
TYR A 266
LEU A 260
None
0.95A 3rqwC-5c65A:
1.7
3rqwD-5c65A:
1.7
3rqwC-5c65A:
21.57
3rqwD-5c65A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 8 PHE A 393
GLU A 252
TYR A 266
LEU A 260
None
0.97A 3rqwI-5c65A:
undetectable
3rqwJ-5c65A:
undetectable
3rqwI-5c65A:
21.57
3rqwJ-5c65A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 8 GLU A 252
TYR A 266
LEU A 260
PHE A 393
None
1.01A 3rqwF-5c65A:
undetectable
3rqwJ-5c65A:
undetectable
3rqwF-5c65A:
21.57
3rqwJ-5c65A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
5 / 12 GLY A 152
GLY A 155
GLU A 452
VAL A 326
LEU A 334
None
1.10A 4fr0A-5c65A:
undetectable
4fr0A-5c65A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
5 / 12 LEU A 276
LEU A 339
ILE A 285
GLY A 284
LEU A 282
None
1.28A 4j26A-5c65A:
undetectable
4j26A-5c65A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
5 / 12 ASN A 413
GLY A  73
GLY A  74
ILE A 127
GLY A 123
None
1.01A 4obwB-5c65A:
undetectable
4obwB-5c65A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 5 ARG A 248
GLY A 396
GLU A 252
SER A 208
None
1.08A 4z3oA-5c65A:
undetectable
4z3oB-5c65A:
undetectable
4z3oA-5c65A:
22.10
4z3oB-5c65A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 6 ILE A 388
PHE A 387
ARG A 454
THR A 333
None
1.04A 5b1aN-5c65A:
0.7
5b1aW-5c65A:
undetectable
5b1aN-5c65A:
24.43
5b1aW-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 7 ILE A 388
PHE A 387
ARG A 454
THR A 333
None
0.91A 5b3sN-5c65A:
0.3
5b3sW-5c65A:
undetectable
5b3sN-5c65A:
24.43
5b3sW-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 5 SER A 208
ARG A 248
GLY A 396
GLU A 252
None
0.88A 5cdqA-5c65A:
1.3
5cdqB-5c65A:
undetectable
5cdqC-5c65A:
1.3
5cdqA-5c65A:
22.54
5cdqB-5c65A:
16.77
5cdqC-5c65A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 5 SER A 208
ARG A 248
GLY A 396
GLU A 252
None
0.89A 5cdqR-5c65A:
1.3
5cdqS-5c65A:
undetectable
5cdqT-5c65A:
undetectable
5cdqR-5c65A:
22.54
5cdqS-5c65A:
16.77
5cdqT-5c65A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
5 / 12 GLY A 380
PHE A  70
PHE A  24
GLY A 128
GLY A 132
None
0.92A 5eqbA-5c65A:
undetectable
5eqbA-5c65A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
3 / 3 LYS A 217
LYS A 243
SER A 246
None
1.35A 5odiA-5c65A:
undetectable
5odiA-5c65A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 8 ILE A 388
PHE A 387
ARG A 454
THR A 333
None
0.91A 5xdxN-5c65A:
0.6
5xdxW-5c65A:
undetectable
5xdxN-5c65A:
24.43
5xdxW-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 5 ILE A 388
PHE A 387
ARG A 454
THR A 333
None
0.93A 5z84N-5c65A:
0.6
5z84W-5c65A:
undetectable
5z84N-5c65A:
24.43
5z84W-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 5 GLN A 277
VAL A 275
PRO A 385
THR A 441
None
1.47A 6cduA-5c65A:
2.2
6cduB-5c65A:
1.8
6cduA-5c65A:
21.24
6cduB-5c65A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo
sapiens)
4 / 5 GLN A 277
VAL A 275
PRO A 385
THR A 441
None
1.50A 6cduI-5c65A:
1.8
6cduJ-5c65A:
1.6
6cduI-5c65A:
21.24
6cduJ-5c65A:
21.24