SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 MET A 648
LEU A 651
SER A 652
 MET  A 648 ( 0.0A)
LEU  A 651 ( 0.5A)
SER  A 652 ( 0.0A)
 0.65A 1ee2A-5c6dA:
undetectable		 1ee2A-5c6dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 ASP A 722
THR A 707
PRO A 708
 ASP  A 722 ( 0.6A)
THR  A 707 ( 0.8A)
PRO  A 708 ( 1.1A)
 0.64A 2q64B-5c6dA:
undetectable		 2q64B-5c6dA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LYS C 657
ASP A 764
MET A 761
GLU A 744
 LYS  C 657 ( 0.0A)
ASP  A 764 ( 0.6A)
MET  A 761 ( 0.0A)
GLU  A 744 ( 0.6A)
 1.42A 3dh0A-5c6dC:
undetectable		 3dh0A-5c6dC:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 ASP A 722
THR A 707
PRO A 708
 ASP  A 722 ( 0.6A)
THR  A 707 ( 0.8A)
PRO  A 708 ( 1.1A)
 0.67A 3tkgD-5c6dA:
undetectable		 3tkgD-5c6dA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 HIS A 578
GLY A 580
TYR A 584
GLU A 586
 HIS  A 578 ( 1.0A)
GLY  A 580 ( 0.0A)
TYR  A 584 ( 1.3A)
GLU  A 586 ( 0.5A)
 1.37A 4ae1B-5c6dA:
undetectable		 4ae1B-5c6dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 HIS A 704
GLN A 574
VAL A 570
ILE A 569
ILE A 620
 HIS  A 704 ( 1.0A)
GLN  A 574 ( 0.6A)
VAL  A 570 ( 0.6A)
ILE  A 569 ( 0.7A)
ILE  A 620 ( 0.7A)
 1.31A 4drhA-5c6dA:
undetectable		 4drhA-5c6dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 HIS A 704
GLN A 574
VAL A 570
ILE A 569
ILE A 620
 HIS  A 704 ( 1.0A)
GLN  A 574 ( 0.6A)
VAL  A 570 ( 0.6A)
ILE  A 569 ( 0.7A)
ILE  A 620 ( 0.7A)
 1.23A 4drhD-5c6dA:
undetectable		 4drhD-5c6dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 VAL A 685
PHE A 688
ARG A 634
 VAL  A 685 ( 0.6A)
PHE  A 688 ( 1.3A)
ARG  A 634 ( 0.6A)
 0.71A 4xr4B-5c6dA:
undetectable		 4xr4B-5c6dA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 LEU A 622
PHE A 661
LEU A 609
PHE A 594
 LEU  A 622 ( 0.6A)
PHE  A 661 ( 1.3A)
LEU  A 609 ( 0.6A)
PHE  A 594 ( 1.3A)
 1.19A 5x1fC-5c6dA:
undetectable
5x1fJ-5c6dA:
undetectable		 5x1fC-5c6dA:
19.21
5x1fJ-5c6dA:
11.92