SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 9 LEU A  14
ALA A 209
ALA A   7
LEU A 245
LEU A 241
 None
 1.05A 1nr6A-5c6mA:
undetectable		 1nr6A-5c6mA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 12 ILE A 188
GLY A 196
LEU A  14
PRO A 199
SER A 141
 None
 1.22A 1zq9A-5c6mA:
undetectable		 1zq9A-5c6mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 9 LEU A  14
ALA A 216
LEU A 220
GLU A 182
LEU A 178
 None
 1.38A 2azqA-5c6mA:
undetectable		 2azqA-5c6mA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 9 THR A 226
LEU A  14
ALA A 216
GLU A 182
LEU A 178
 None
 1.45A 2azqA-5c6mA:
undetectable		 2azqA-5c6mA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 12 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.12A 3eeyA-5c6mA:
undetectable		 3eeyA-5c6mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 12 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.12A 3eeyB-5c6mA:
undetectable		 3eeyB-5c6mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 12 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.06A 3eeyI-5c6mA:
undetectable		 3eeyI-5c6mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 12 ILE A  53
ALA A  71
LEU A  20
PRO A  77
ARG A  51
 None
None
None
None
CL  A 302 (-4.2A)
 1.17A 4gh8B-5c6mA:
undetectable		 4gh8B-5c6mA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Shewanella
halifaxensis) 		5 / 12 GLY A 142
ILE A 183
ALA A 180
ALA A 148
ARG A 151
 None
 1.20A 4kicA-5c6mA:
undetectable		 4kicA-5c6mA:
20.98