SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 291
PHE A 301
LEU A  75
LEU A  51
 None
 1.36A 1skxA-5c6uA:
undetectable		 1skxA-5c6uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 216
PHE A 252
ILE A 107
ILE A 151
PHE A 132
 None
 1.03A 1z11A-5c6uA:
undetectable		 1z11A-5c6uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 216
PHE A 252
ILE A 107
ILE A 151
PHE A 132
 None
 1.07A 1z11B-5c6uA:
undetectable		 1z11B-5c6uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 216
PHE A 252
ILE A 107
ILE A 151
PHE A 132
 None
 1.08A 1z11C-5c6uA:
undetectable		 1z11C-5c6uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 216
PHE A 252
ILE A 107
ILE A 151
PHE A 132
 None
 1.08A 1z11D-5c6uA:
undetectable		 1z11D-5c6uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 392
THR A 374
VAL A 373
ALA A 394
 None
 0.93A 2e1qA-5c6uA:
undetectable		 2e1qA-5c6uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 392
THR A 374
VAL A 373
ALA A 394
 None
 0.90A 2e1qC-5c6uA:
undetectable		 2e1qC-5c6uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 114
GLY A 116
PHE A 110
 None
 0.63A 2m2pB-5c6uA:
undetectable		 2m2pB-5c6uA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  75
PRO A  76
ARG A  59
 None
 0.60A 2qd4B-5c6uA:
undetectable		 2qd4B-5c6uA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  75
PRO A  76
ARG A  59
 None
 0.59A 2qd5A-5c6uA:
undetectable		 2qd5A-5c6uA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A   6
GLN A   9
THR A 419
HIS A  18
 None
 1.34A 2zj0B-5c6uA:
2.7		 2zj0B-5c6uA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A   6
GLN A   9
THR A 419
HIS A  18
 None
 1.29A 2zj0C-5c6uA:
undetectable		 2zj0C-5c6uA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A   6
GLN A   9
THR A 419
HIS A  18
 None
 1.36A 3ce6B-5c6uA:
2.7		 3ce6B-5c6uA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A  66
VAL A 265
ALA A  95
THR A 259
THR A 255
 None
 1.29A 3dl9B-5c6uA:
undetectable		 3dl9B-5c6uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 310
HIS A 314
MET A 311
 None
 0.99A 3mihA-5c6uA:
undetectable		 3mihA-5c6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A 351
PRO A 137
GLY A 138
LEU A  34
ASP A  33
 None
None
CL  A 503 ( 3.8A)
None
None
 1.40A 3r24A-5c6uA:
undetectable		 3r24A-5c6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 391
ILE A 393
VAL A 407
LEU A 410
 None
 0.70A 3r9vA-5c6uA:
undetectable
3r9vB-5c6uA:
undetectable		 3r9vA-5c6uA:
22.27
3r9vB-5c6uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 392
THR A 374
VAL A 373
ALA A 394
 None
 0.81A 3uniA-5c6uA:
undetectable		 3uniA-5c6uA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 325
LEU A 329
ILE A 391
VAL A 373
ALA A 406
 None
 0.96A 4o1zB-5c6uA:
undetectable		 4o1zB-5c6uA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 333
SER A 336
LEU A 355
LEU A 329
LEU A 415
 None
 1.42A 4or0A-5c6uA:
undetectable		 4or0A-5c6uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 TRP A 217
THR A 183
GLY A 180
ARG A 248
LEU A 203
 None
 1.47A 4uinH-5c6uA:
undetectable
4uinL-5c6uA:
undetectable		 4uinH-5c6uA:
21.18
4uinL-5c6uA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 319
GLN A 316
LEU A 226
LEU A 228
 None
 1.09A 4xp3A-5c6uA:
undetectable		 4xp3A-5c6uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 140
ARG A 141
TYR A 139
 None
None
PLP  A 501 ( 3.6A)
 1.04A 5a7mA-5c6uA:
undetectable		 5a7mA-5c6uA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 140
ARG A 141
TYR A 139
 None
None
PLP  A 501 ( 3.6A)
 1.01A 5a7mB-5c6uA:
undetectable		 5a7mB-5c6uA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  74
ASP A 290
LEU A  50
GLY A 264
SER A 266
 None
 1.03A 5vooA-5c6uA:
undetectable		 5vooA-5c6uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  74
ASP A 290
LEU A  50
GLY A 264
SER A 266
 None
 1.04A 5vooC-5c6uA:
undetectable		 5vooC-5c6uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  74
ASP A 290
LEU A  50
GLY A 264
SER A 266
 None
 0.99A 5vooE-5c6uA:
undetectable		 5vooE-5c6uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  74
ASP A 290
LEU A  50
GLY A 264
SER A 266
 None
 1.02A 5vopA-5c6uA:
undetectable		 5vopA-5c6uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  85
ILE A  81
GLN A 294
LEU A  50
ILE A 258
 None
 1.23A 5y2tB-5c6uA:
undetectable		 5y2tB-5c6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 389
ASN A 390
SER A 351
 None
 1.11A 5yw0A-5c6uA:
undetectable		 5yw0A-5c6uA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5c6u AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 395
VAL A 325
GLY A 370
VAL A 373
 None
 0.86A 6ak3B-5c6uA:
undetectable		 6ak3B-5c6uA:
11.83