SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 12 LEU A 490
LEU A 486
GLN A 475
LEU A 466
THR A 494
 None
 1.42A 1a28B-5c70A:
undetectable		 1a28B-5c70A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 8 LEU A 584
ALA A 581
VAL A 571
VAL A 549
 None
 0.87A 1epbB-5c70A:
undetectable		 1epbB-5c70A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 8 SER A   0
ILE A 397
MET A 340
SER A 405
 None
 1.05A 1kb9A-5c70A:
undetectable
1kb9C-5c70A:
undetectable
1kb9D-5c70A:
undetectable
1kb9E-5c70A:
undetectable		 1kb9A-5c70A:
21.57
1kb9C-5c70A:
21.04
1kb9D-5c70A:
17.64
1kb9E-5c70A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 VAL A 102
ALA A 103
HIS A 105
 None
 0.68A 1q23L-5c70A:
undetectable		 1q23L-5c70A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 VAL A 102
ALA A 103
HIS A 105
 None
 0.75A 1q23J-5c70A:
undetectable		 1q23J-5c70A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 12 ARG A 329
GLU A 505
PHE A 163
ASN A 467
VAL A 447
 None
 1.48A 1x70A-5c70A:
undetectable		 1x70A-5c70A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 10 LEU A 119
ASN A 100
GLY A  99
ASN A  98
PHE A 126
 None
 1.37A 2ok6A-5c70A:
undetectable
2ok6H-5c70A:
undetectable		 2ok6A-5c70A:
20.65
2ok6H-5c70A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 5 ILE A 501
LEU A 464
ASP A 498
ALA A 543
 None
 0.89A 2opxA-5c70A:
undetectable		 2opxA-5c70A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 8 PHE A 317
ILE A 348
PHE A 572
GLY A 294
 None
 0.78A 2qx4A-5c70A:
undetectable
2qx4B-5c70A:
undetectable		 2qx4A-5c70A:
17.97
2qx4B-5c70A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		6 / 12 ASP A 162
ASN A 413
GLU A 414
TYR A 469
GLU A 505
TRP A 550
 None
 0.90A 2v3dA-5c70A:
17.7		 2v3dA-5c70A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		6 / 11 ASP A 162
ASN A 413
GLU A 414
TYR A 469
GLU A 505
TRP A 550
 None
 0.92A 2v3dB-5c70A:
17.3		 2v3dB-5c70A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 6 LEU A  12
ILE A  13
ARG A  69
VAL A 314
 None
 1.02A 2ygoA-5c70A:
undetectable		 2ygoA-5c70A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 12 PHE A 526
GLY A 513
LEU A 514
ALA A 512
VAL A 511
 None
 1.10A 3av6A-5c70A:
undetectable		 3av6A-5c70A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 12 GLU A 113
TYR A 267
TYR A 176
VAL A 178
HIS A 182
 None
 1.49A 3bjmA-5c70A:
2.2		 3bjmA-5c70A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 5 GLN A 548
THR A 504
GLU A 353
THR A 354
 None
 1.29A 3glqB-5c70A:
undetectable		 3glqB-5c70A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 ILE A  52
PHE A  21
HIS A  59
 None
 0.62A 3h0aA-5c70A:
undetectable		 3h0aA-5c70A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 ASN A 413
ALA A 445
ARG A 329
 None
 0.73A 3tj7C-5c70A:
undetectable
3tj7D-5c70A:
undetectable		 3tj7C-5c70A:
14.65
3tj7D-5c70A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 5 PRO A 441
ILE A 348
TRP A 242
PHE A 283
 None
 1.04A 3topB-5c70A:
9.5		 3topB-5c70A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 7 ALA A  88
ARG A 399
HIS A 105
GLY A 107
 None
 1.01A 3v4tH-5c70A:
undetectable		 3v4tH-5c70A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 12 GLU A 113
TYR A 267
TYR A 176
VAL A 178
HIS A 182
 None
 1.47A 3w2tA-5c70A:
undetectable		 3w2tA-5c70A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 8 LEU A 136
THR A  90
TYR A 333
TYR A 109
 None
 1.28A 3wipF-5c70A:
undetectable
3wipJ-5c70A:
undetectable		 3wipF-5c70A:
18.62
3wipJ-5c70A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 SER A  78
ALA A 121
VAL A 120
 None
 0.59A 4o2bA-5c70A:
undetectable		 4o2bA-5c70A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 12 ALA A 458
LEU A 466
ASN A 413
PHE A 444
SER A 410
 None
 1.25A 4pd5A-5c70A:
undetectable		 4pd5A-5c70A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 12 GLN A 527
LEU A 514
ALA A 508
ASN A 567
ASP A 554
 None
 1.32A 4qckA-5c70A:
undetectable		 4qckA-5c70A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		5 / 11 GLY A 245
PHE A 290
ILE A 285
PHE A 283
PHE A 292
 None
 1.16A 4qoiA-5c70A:
undetectable
4qoiB-5c70A:
undetectable		 4qoiA-5c70A:
17.97
4qoiB-5c70A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 ASP A 400
HIS A 403
LYS A 401
 None
 0.90A 4qzuD-5c70A:
undetectable		 4qzuD-5c70A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 7 GLU A 341
GLU A 338
GLU A 337
GLU A  87
 None
 1.13A 4r87I-5c70A:
undetectable		 4r87I-5c70A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 4 ASN A 286
VAL A 239
THR A 190
ILE A 199
 None
 1.28A 4retA-5c70A:
undetectable		 4retA-5c70A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 4 ASN A 286
VAL A 239
THR A 190
ILE A 199
 None
 1.28A 4retC-5c70A:
undetectable		 4retC-5c70A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 5 MET A 530
MET A 533
GLU A 483
LEU A 486
 None
 1.33A 4v2oA-5c70A:
undetectable
4v2oC-5c70A:
undetectable		 4v2oA-5c70A:
7.84
4v2oC-5c70A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 ALA A 131
TRP A  64
VAL A  65
 None
 0.41A 4w9nC-5c70A:
undetectable		 4w9nC-5c70A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 ASN A 467
ALA A 445
ARG A 329
 None
 0.77A 5cvtB-5c70A:
undetectable		 5cvtB-5c70A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 8 ASN A 467
TRP A 589
HIS A 535
THR A 330
 None
 1.21A 5hqaA-5c70A:
8.6		 5hqaA-5c70A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 6 HIS A 398
ILE A 186
TYR A 267
TYR A 176
 None
 1.21A 5ih0A-5c70A:
undetectable		 5ih0A-5c70A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 4 VAL A 224
VAL A 216
TYR A 250
GLN A 251
 None
 1.34A 5qggA-5c70A:
undetectable		 5qggA-5c70A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 4 VAL A 224
VAL A 216
TYR A 250
GLN A 251
 None
 1.32A 5qgoA-5c70A:
undetectable		 5qgoA-5c70A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		4 / 4 VAL A 224
VAL A 216
TYR A 250
GLN A 251
 None
 1.30A 5qgpA-5c70A:
undetectable		 5qgpA-5c70A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 SER A  78
ALA A 121
VAL A 120
 None
 0.50A 5xiwC-5c70A:
2.6		 5xiwC-5c70A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 TYR A 534
HIS A 535
PHE A 538
 None
 1.03A 6esmA-5c70A:
undetectable		 6esmA-5c70A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5c70 GLUCURONIDASE
(Aspergillus
oryzae) 		3 / 3 TRP A 409
ILE A 351
ASP A 352
 None
 0.61A 6i0y7-5c70A:
undetectable		 6i0y7-5c70A:
3.81