SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 127
VAL A 103
TYR A 101
TYR A 124
 None
 0.74A 1lweA-5c77A:
undetectable		 1lweA-5c77A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 127
VAL A 103
TYR A 101
TYR A 124
 None
 0.87A 1s1xA-5c77A:
undetectable		 1s1xA-5c77A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 120
SER A  35
LEU A  75
LEU A  82
 None
 0.97A 1yajD-5c77A:
undetectable		 1yajD-5c77A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  23
THR A 146
PHE A 102
TYR A   3
 None
 1.21A 3em0A-5c77A:
undetectable		 3em0A-5c77A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 127
VAL A 103
TYR A 101
TYR A 124
 None
 0.83A 3v81C-5c77A:
undetectable		 3v81C-5c77A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 127
VAL A 103
TYR A 101
TYR A 124
 None
 0.86A 4b3qA-5c77A:
undetectable		 4b3qA-5c77A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 193
ILE A 200
TYR A 182
PHE A 168
 None
 1.24A 4g10A-5c77A:
undetectable		 4g10A-5c77A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A   7
LEU A  34
LEU A  55
LEU A  50
TYR A  20
 None
 1.32A 4xumA-5c77A:
undetectable		 4xumA-5c77A:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		7 / 12 LEU A  83
PRO A  85
PHE A 104
ARG A 132
LEU A 133
MET A 138
ALA A 143
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-4.9A)
SAH  A 301 ( 4.0A)
 0.34A 5h5fA-5c77A:
29.1		 5h5fA-5c77A:
91.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 128
ALA A 123
LEU A  62
THR A  58
ILE A   4
 None
 1.11A 5itzB-5c77A:
undetectable		 5itzB-5c77A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 148
THR A 147
PHE A 104
LEU A  24
GLU A  26
 None
None
SAH  A 301 (-4.8A)
None
None
 1.49A 5l8oB-5c77A:
undetectable		 5l8oB-5c77A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  83
PRO A  85
GLY A 105
GLY A 106
LEU A 133
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.0A)
 0.75A 5o96A-5c77A:
8.2
5o96B-5c77A:
9.3		 5o96A-5c77A:
20.87
5o96B-5c77A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  83
PRO A  85
GLY A 106
LEU A 133
ALA A 143
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.0A)
SAH  A 301 ( 4.0A)
 0.52A 5o96A-5c77A:
8.2
5o96B-5c77A:
9.3		 5o96A-5c77A:
20.87
5o96B-5c77A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  83
GLY A 106
LEU A 133
THR A 140
ALA A 143
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.0A)
SAH  A 301 (-4.0A)
SAH  A 301 ( 4.0A)
 0.88A 5o96G-5c77A:
8.3		 5o96G-5c77A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  83
PRO A  85
GLY A 105
GLY A 106
LEU A 133
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.0A)
 0.91A 5o96G-5c77A:
8.3
5o96H-5c77A:
8.8		 5o96G-5c77A:
20.87
5o96H-5c77A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		6 / 10 LEU A  83
PRO A  85
GLY A 106
LEU A 133
THR A 140
ALA A 143
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.0A)
SAH  A 301 (-4.0A)
SAH  A 301 ( 4.0A)
 0.88A 5o96G-5c77A:
8.3
5o96H-5c77A:
8.8		 5o96G-5c77A:
20.87
5o96H-5c77A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A   5
LEU A  82
ILE A  65
LEU A  37
THR A  58
 None
 1.26A 5tiwB-5c77A:
undetectable		 5tiwB-5c77A:
21.90