SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
5 / 11 ALA A  91
GLU A  31
ARG A  86
ARG A 302
GLU A 156
None
1.29A 1mjlA-5c78A:
undetectable
1mjlB-5c78A:
undetectable
1mjlA-5c78A:
11.50
1mjlB-5c78A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
4 / 8 LEU A 349
GLU A 348
ILE A 408
TYR A 421
None
1.07A 1qvtA-5c78A:
1.2
1qvtA-5c78A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
5 / 11 TYR A  93
LEU A  97
PRO A 305
ASN A 308
LEU A  21
None
1.35A 2ft9A-5c78A:
undetectable
2ft9A-5c78A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
5 / 12 ILE A 523
LEU A 508
MET A 536
ALA A 540
ARG A 542
None
1.42A 2noaA-5c78A:
undetectable
2noaA-5c78A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
4 / 5 LEU A 163
ALA A 165
LEU A 169
MET A  39
None
1.25A 2oaxA-5c78A:
undetectable
2oaxA-5c78A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
4 / 7 LEU A 555
PHE A 365
ILE A 395
GLY A 382
None
0.93A 2v0mC-5c78A:
undetectable
2v0mC-5c78A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
5 / 10 VAL A 297
ILE A 170
MET A  39
ILE A 289
ILE A 293
None
1.22A 3clbD-5c78A:
undetectable
3clbD-5c78A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
5 / 10 VAL A 297
ILE A 170
MET A  39
ILE A 289
ILE A 293
None
1.19A 3hbbD-5c78A:
2.3
3hbbD-5c78A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
3 / 3 SER A 389
ASP A 509
ASN A 431
None
0.84A 3lsfB-5c78A:
undetectable
3lsfE-5c78A:
undetectable
3lsfB-5c78A:
18.95
3lsfE-5c78A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
3 / 3 ASP A 509
ASN A 431
SER A 389
None
0.84A 3lsfB-5c78A:
undetectable
3lsfE-5c78A:
undetectable
3lsfB-5c78A:
18.95
3lsfE-5c78A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
4 / 6 PHE A 150
SER A  24
LEU A 152
LEU A 153
None
1.38A 5dzke-5c78A:
undetectable
5dzks-5c78A:
undetectable
5dzke-5c78A:
16.02
5dzks-5c78A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
5 / 12 ALA A 461
ILE A 443
GLY A 426
LEU A 508
ILE A 530
None
1.01A 5m24A-5c78A:
undetectable
5m24A-5c78A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni)
3 / 3 ARG A 302
PHE A  94
ARG A 309
None
1.23A 5y9yA-5c78A:
undetectable
5y9yA-5c78A:
21.20