SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 7 PHE A 842
THR A 832
VAL A 831
ALA A 797
 None
 1.09A 1fo4B-5c7mA:
undetectable		 1fo4B-5c7mA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		5 / 12 TYR A 880
LEU A 877
TYR A 883
GLN A 885
PHE A 815
 None
 1.50A 1s2aA-5c7mA:
undetectable		 1s2aA-5c7mA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 640
ILE A 624
GLY A 642
THR A 754
GLU A 752
 None
 1.21A 1sg9A-5c7mA:
undetectable		 1sg9A-5c7mA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		6 / 12 LEU A 886
PHE A 815
LEU A 877
LEU A 875
ILE A 894
ALA A 893
 None
 1.45A 2bxqA-5c7mA:
undetectable		 2bxqA-5c7mA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.05A 2dysP-5c7mA:
undetectable
2dysW-5c7mA:
undetectable		 2dysP-5c7mA:
19.45
2dysW-5c7mA:
8.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5c7m POLYUBIQUITIN-C
(Homo
sapiens) 		4 / 4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.02A 2fcnA-5c7mB:
15.3		 2fcnA-5c7mB:
80.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5c7m POLYUBIQUITIN-C
(Homo
sapiens) 		4 / 6 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.59A 2fcnA-5c7mB:
15.3
2fcnB-5c7mB:
14.8		 2fcnA-5c7mB:
80.26
2fcnB-5c7mB:
80.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.01A 2zxwP-5c7mA:
undetectable
2zxwW-5c7mA:
undetectable		 2zxwP-5c7mA:
19.45
2zxwW-5c7mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.00A 3ag1C-5c7mA:
undetectable
3ag1J-5c7mA:
undetectable		 3ag1C-5c7mA:
19.45
3ag1J-5c7mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A 757
VAL A 604
THR A 657
PHE A 659
 None
 1.35A 3ltwA-5c7mA:
undetectable		 3ltwA-5c7mA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 6 GLU A 559
TYR A 637
HIS A 634
PHE A 558
 None
 1.19A 4a97E-5c7mA:
undetectable		 4a97E-5c7mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 6 GLU A 559
TYR A 637
HIS A 634
PHE A 562
 None
 1.02A 4a97E-5c7mA:
undetectable		 4a97E-5c7mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		5 / 11 GLY A 784
CYH A 783
ALA A 648
ILE A 645
LEU A 770
 None
 0.99A 4xumB-5c7mA:
undetectable		 4xumB-5c7mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A 644
ALA A 646
HIS A 651
LEU A 573
 None
 1.04A 5dzkB-5c7mA:
undetectable
5dzkP-5c7mA:
undetectable		 5dzkB-5c7mA:
20.49
5dzkP-5c7mA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.02A 5iy5P-5c7mA:
undetectable
5iy5W-5c7mA:
undetectable		 5iy5P-5c7mA:
19.20
5iy5W-5c7mA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 0.96A 5w97C-5c7mA:
undetectable
5w97J-5c7mA:
undetectable		 5w97C-5c7mA:
19.45
5w97J-5c7mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.00A 5x1fC-5c7mA:
undetectable
5x1fJ-5c7mA:
undetectable		 5x1fC-5c7mA:
19.45
5x1fJ-5c7mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 8 PHE A 638
ILE A 641
PHE A 612
PHE A 663
 None
 1.10A 5x23A-5c7mA:
undetectable		 5x23A-5c7mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.01A 5xdxC-5c7mA:
undetectable
5xdxJ-5c7mA:
undetectable		 5xdxC-5c7mA:
19.20
5xdxJ-5c7mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
POLYUBIQUITIN-C
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR A 609
PRO A 607
LEU B   8
 None
 0.90A 6beoA-5c7mA:
undetectable		 6beoA-5c7mA:
3.31