SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		3 / 3 TRP A 158
VAL A 259
TRP A 340
 None
None
MLR  A 501 (-4.0A)
 1.26A 1c4dA-5c7rA:
undetectable
1c4dB-5c7rA:
undetectable		 1c4dA-5c7rA:
2.38
1c4dB-5c7rA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 6 VAL A 375
VAL A 390
ILE A 381
ARG A 409
 None
 1.13A 1iepA-5c7rA:
undetectable		 1iepA-5c7rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 8 SER A 255
THR A 225
ASN A 150
LEU A 247
 None
 1.00A 1lhvA-5c7rA:
undetectable		 1lhvA-5c7rA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 None
 0.98A 2h42C-5c7rA:
undetectable		 2h42C-5c7rA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-5c7rA:
undetectable		 2ve3A-5c7rA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 12 LEU A 192
THR A 193
ALA A 346
THR A 345
ILE A 348
 None
 1.22A 3a35A-5c7rA:
undetectable		 3a35A-5c7rA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 6 ALA A 188
LEU A 192
ALA A 346
THR A 345
 None
 0.92A 3b6hA-5c7rA:
undetectable		 3b6hA-5c7rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.93A 3bgdA-5c7rA:
undetectable		 3bgdA-5c7rA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.69A 3bjwC-5c7rA:
undetectable		 3bjwC-5c7rA:
13.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		12 / 12 ASP A  14
LYS A  15
LYS A  42
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
PRO A 154
TRP A 230
TYR A 341
 MLR  A 501 (-2.9A)
MLR  A 501 (-2.6A)
None
MLR  A 501 (-3.8A)
MLR  A 501 (-4.2A)
MLR  A 501 (-3.2A)
MLR  A 501 (-2.8A)
MLR  A 501 (-3.5A)
MLR  A 501 (-2.9A)
MLR  A 501 (-3.4A)
MLR  A 501 ( 4.5A)
MLR  A 501 ( 4.3A)
 0.37A 3jyrA-5c7rA:
62.7		 3jyrA-5c7rA:
76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 MLR  A 501 (-4.7A)
MLR  A 501 (-4.5A)
MLR  A 501 (-3.2A)
MLR  A 501 (-3.9A)
MLR  A 501 ( 4.3A)
MLR  A 501 (-4.0A)
 0.14A 3jyrA-5c7rA:
62.7		 3jyrA-5c7rA:
76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		6 / 7 ASN A  12
TRP A  62
TYR A 155
MET A 330
TRP A 340
ARG A 344
 MLR  A 501 (-4.7A)
MLR  A 501 (-4.5A)
MLR  A 501 (-3.9A)
MLR  A 501 ( 4.3A)
MLR  A 501 (-4.0A)
None
 0.57A 3jyrA-5c7rA:
62.7		 3jyrA-5c7rA:
76.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 6 VAL A 375
VAL A 390
ILE A 381
ARG A 409
 None
 0.89A 3ms9A-5c7rA:
undetectable		 3ms9A-5c7rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 6 VAL A 375
VAL A 390
ILE A 381
ARG A 409
 None
 0.86A 3mssA-5c7rA:
undetectable		 3mssA-5c7rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 6 VAL A 375
VAL A 390
ILE A 381
ARG A 409
 None
 0.87A 3mssC-5c7rA:
undetectable		 3mssC-5c7rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.98A 3n8yB-5c7rA:
undetectable		 3n8yB-5c7rA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MLR  A 501 (-2.9A)
None
 0.88A 3tbgB-5c7rA:
undetectable		 3tbgB-5c7rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MLR  A 501 (-2.9A)
None
 0.86A 3tbgD-5c7rA:
undetectable		 3tbgD-5c7rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.33A 3vwqA-5c7rA:
undetectable		 3vwqA-5c7rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.36A 3vywD-5c7rA:
undetectable		 3vywD-5c7rA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 7 GLN A 253
THR A 128
THR A 320
MET A 321
 None
 1.10A 4mbsA-5c7rA:
undetectable		 4mbsA-5c7rA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-5c7rA:
undetectable		 4or0B-5c7rA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		4 / 4 LEU A  76
ARG A  66
ILE A  60
PHE A  47
 None
MLR  A 501 (-3.5A)
None
None
 1.30A 5kirB-5c7rA:
undetectable		 5kirB-5c7rA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
SO4  A 502 ( 4.0A)
None
None
None
None
 1.43A 5w4zA-5c7rA:
undetectable		 5w4zA-5c7rA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
SO4  A 502 ( 4.0A)
None
None
None
None
 1.46A 5w4zB-5c7rA:
undetectable		 5w4zB-5c7rA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 MLR  A 501 (-3.9A)
None
None
 0.79A 6b58A-5c7rA:
undetectable		 6b58A-5c7rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12
(Escherichia
coli;
Zoarces
americanus) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.38A 6bm5A-5c7rA:
undetectable		 6bm5A-5c7rA:
23.92