SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		3 / 3 PRO A 173
THR A 202
PRO A 200
 None
 0.76A 2d55C-5c8aA:
undetectable		 2d55C-5c8aA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		5 / 10 LEU A 188
VAL A 193
GLY A 192
LEU A 270
ALA A 271
 None
None
None
B12  A 300 ( 4.4A)
None
 0.81A 2v3kA-5c8aA:
undetectable		 2v3kA-5c8aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		5 / 9 PRO A 233
GLY A 235
ALA A 236
ARG A 208
LEU A 204
 None
 1.38A 3ur0C-5c8aA:
2.0		 3ur0C-5c8aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		5 / 10 VAL A 127
GLU A 141
VAL A 123
SER A 145
LEU A 148
 B12  A 300 ( 4.9A)
B12  A 300 ( 3.4A)
None
B12  A 300 (-3.0A)
None
 1.14A 4yb6A-5c8aA:
undetectable
4yb6E-5c8aA:
undetectable		 4yb6A-5c8aA:
25.57
4yb6E-5c8aA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		5 / 10 VAL A 127
GLU A 141
VAL A 123
SER A 145
LEU A 148
 B12  A 300 ( 4.9A)
B12  A 300 ( 3.4A)
None
B12  A 300 (-3.0A)
None
 1.14A 4yb6B-5c8aA:
undetectable
4yb6C-5c8aA:
2.2		 4yb6B-5c8aA:
25.57
4yb6C-5c8aA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		5 / 10 GLY A 128
VAL A 127
GLU A 141
SER A 145
LEU A 148
 B12  A 300 (-3.6A)
B12  A 300 ( 4.9A)
B12  A 300 ( 3.4A)
B12  A 300 (-3.0A)
None
 1.36A 4yb6C-5c8aA:
2.2
4yb6F-5c8aA:
undetectable		 4yb6C-5c8aA:
25.57
4yb6F-5c8aA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		5 / 10 SER A 145
LEU A 148
VAL A 127
GLU A 141
VAL A 123
 B12  A 300 (-3.0A)
None
B12  A 300 ( 4.9A)
B12  A 300 ( 3.4A)
None
 1.16A 4yb6B-5c8aA:
undetectable
4yb6F-5c8aA:
undetectable		 4yb6B-5c8aA:
25.57
4yb6F-5c8aA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH
(Thermus
thermophilus) 		5 / 12 LEU A 152
LEU A 124
LEU A 121
GLY A  84
LEU A  87
 None
B12  A 300 (-4.1A)
B12  A 300 (-4.3A)
None
None
 1.07A 5gtrA-5c8aA:
undetectable		 5gtrA-5c8aA:
22.05