SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 LEU B 117
ALA B 270
ASP B 273
ILE B 275
GLY B  88
 None
 1.15A 1d4sA-5c8sB:
undetectable		 1d4sA-5c8sB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 10 LEU B 117
ALA B 270
ASP B 273
ILE B 275
GLY B  88
 None
 1.15A 1d4yA-5c8sB:
undetectable		 1d4yA-5c8sB:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 CYH B 261
ASP B 258
VAL B 263
HIS B 257
 ZN  B 602 (-2.0A)
None
None
ZN  B 602 (-3.2A)
 1.46A 1ekjG-5c8sB:
undetectable
1ekjH-5c8sB:
undetectable		 1ekjG-5c8sB:
20.56
1ekjH-5c8sB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 SER B 220
TYR B 224
SER B 171
ASP B 234
 None
 1.42A 1vidA-5c8sB:
undetectable		 1vidA-5c8sB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 PHE B 426
ARG B  84
ASN B 410
 G3A  B 606 (-3.4A)
None
None
 0.91A 1xzxX-5c8sB:
undetectable		 1xzxX-5c8sB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 SER B 220
TYR B 224
SER B 171
ASP B 234
 None
 1.37A 2cl5B-5c8sB:
4.5		 2cl5B-5c8sB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 THR B 437
PRO B 393
TYR B 370
 None
 0.92A 2dxrA-5c8sB:
undetectable		 2dxrA-5c8sB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 TRP B 159
GLY B 110
GLY B  93
PHE B 198
 None
 0.86A 2qx6A-5c8sB:
undetectable
2qx6B-5c8sB:
undetectable		 2qx6A-5c8sB:
15.54
2qx6B-5c8sB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 SER B 220
TYR B 224
SER B 171
ASP B 234
 None
 1.39A 2zvjA-5c8sB:
undetectable		 2zvjA-5c8sB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 PHE B  60
PHE B   8
LYS B   9
GLY B 102
 None
 1.08A 3em0B-5c8sB:
undetectable		 3em0B-5c8sB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL B 236
LEU B 174
MET B 169
VAL B 181
THR B 113
 None
 1.12A 3frqA-5c8sB:
undetectable		 3frqA-5c8sB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 11 PHE B 506
CYH B 399
SER B 418
VAL B 398
PHE B 436
 G3A  B 606 (-3.8A)
None
None
None
None
 1.47A 3u9fA-5c8sB:
undetectable
3u9fC-5c8sB:
undetectable		 3u9fA-5c8sB:
18.38
3u9fC-5c8sB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 THR B 437
VAL B 398
PRO B 393
TYR B 370
 None
 1.18A 4grkA-5c8sB:
undetectable		 4grkA-5c8sB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 TYR B 446
HIS B 486
ARG B 476
 None
 0.98A 4htfA-5c8sB:
7.9		 4htfA-5c8sB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 THR B 173
ARG B  84
PHE B 111
SER B 112
 None
 1.14A 4o4dA-5c8sB:
undetectable		 4o4dA-5c8sB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 MET B 315
MET B 500
TYR B 491
 None
 1.23A 4p6xI-5c8sB:
undetectable		 4p6xI-5c8sB:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		11 / 11 TRP B 292
GLY B 333
PRO B 335
ASP B 352
ALA B 353
PHE B 367
TYR B 368
TRP B 385
ASN B 386
CYH B 387
VAL B 389
 None
SAH  B 605 (-3.3A)
SAH  B 605 (-3.8A)
SAH  B 605 (-2.3A)
SAH  B 605 (-3.5A)
SAH  B 605 (-3.5A)
None
G3A  B 606 ( 4.1A)
G3A  B 606 ( 3.8A)
SAH  B 605 ( 3.8A)
SAH  B 605 (-4.7A)
 0.41A 5c8tB-5c8sB:
49.2		 5c8tB-5c8sB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8T_D_SAMD605_0
(GUANINE-N7
METHYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		10 / 10 TRP B 292
GLY B 333
ASN B 334
PRO B 335
ASP B 352
ALA B 353
GLN B 354
PHE B 367
TRP B 385
CYH B 387
 None
SAH  B 605 (-3.3A)
SAH  B 605 (-4.1A)
SAH  B 605 (-3.8A)
SAH  B 605 (-2.3A)
SAH  B 605 (-3.5A)
None
SAH  B 605 (-3.5A)
G3A  B 606 ( 4.1A)
SAH  B 605 ( 3.8A)
 0.71A 5c8tD-5c8sB:
45.9		 5c8tD-5c8sB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 THR B 122
LEU B 105
HIS B 268
PRO B 141
PHE B 190
 None
 1.29A 5dlvA-5c8sB:
undetectable		 5dlvA-5c8sB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 SER B 220
TYR B 224
SER B 171
ASP B 234
 None
 1.38A 5fhrA-5c8sB:
undetectable		 5fhrA-5c8sB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5c8s GUANINE-N7
METHYLTRANSFERASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 LEU B  54
CYH B  94
HIS B  95
LEU B 105
 None
 1.06A 5hpuC-5c8sB:
undetectable
5hpuD-5c8sB:
undetectable		 5hpuC-5c8sB:
4.60
5hpuD-5c8sB:
5.34