SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.03A 1cd2A-5c8wA:
undetectable		 1cd2A-5c8wA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 11 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.06A 1dyrA-5c8wA:
undetectable		 1dyrA-5c8wA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.10A 1rb2B-5c8wA:
undetectable		 1rb2B-5c8wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.12A 1re7A-5c8wA:
undetectable		 1re7A-5c8wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 11 LEU A 169
LEU A 163
ILE A 236
ASN A 203
MET A 184
 None
None
None
MLA  A 301 (-4.9A)
None
 1.36A 2ft9A-5c8wA:
undetectable		 2ft9A-5c8wA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 4 ILE A 196
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
None
None
PCG  A 302 ( 2.8A)
 1.00A 3ia4A-5c8wA:
undetectable		 3ia4A-5c8wA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 GLY A 202
PHE A 206
GLY A 232
PHE A 231
 MLA  A 301 ( 4.0A)
None
PCG  A 302 (-3.6A)
None
 0.99A 3ko0M-5c8wA:
undetectable
3ko0P-5c8wA:
undetectable		 3ko0M-5c8wA:
21.57
3ko0P-5c8wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 THR A 229
ILE A 225
VAL A 215
GLY A 232
 None
None
PCG  A 302 (-4.7A)
PCG  A 302 (-3.6A)
 0.92A 4eq4B-5c8wA:
undetectable		 4eq4B-5c8wA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.12A 4g8zX-5c8wA:
undetectable		 4g8zX-5c8wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.10A 4km0A-5c8wA:
undetectable		 4km0A-5c8wA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.09A 4km0B-5c8wA:
undetectable		 4km0B-5c8wA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.06A 4ptjA-5c8wA:
undetectable		 4ptjA-5c8wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 9 ILE A 225
VAL A 252
THR A 254
ILE A 195
 None
 1.03A 5lg3I-5c8wA:
undetectable		 5lg3I-5c8wA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5c8w CGMP-DEPENDENT
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 196
ALA A 244
PHE A 231
ILE A 195
THR A 243
 PCG  A 302 ( 4.1A)
PCG  A 302 (-3.8A)
None
None
PCG  A 302 ( 2.8A)
 1.07A 7dfrA-5c8wA:
undetectable		 7dfrA-5c8wA:
20.12