SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		5 / 12 ILE A  81
SER A  70
ILE A  36
LEU A  32
ILE A  77
 None
 1.04A 1draA-5c90A:
undetectable		 1draA-5c90A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		4 / 7 LEU A 126
MET A 121
VAL A 120
SER A 101
 None
None
None
MPD  A2001 (-3.3A)
 1.12A 1wrlA-5c90A:
undetectable
1wrlB-5c90A:
undetectable		 1wrlA-5c90A:
20.51
1wrlB-5c90A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		5 / 12 ILE A  81
SER A  70
ILE A  36
LEU A  32
ILE A  77
 None
 1.03A 2drcA-5c90A:
undetectable		 2drcA-5c90A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		5 / 12 ILE A  81
SER A  70
ILE A  36
LEU A  32
ILE A  77
 None
 1.02A 3drcA-5c90A:
undetectable		 3drcA-5c90A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		5 / 12 ALA A  97
ALA A  96
LEU A 104
VAL A  40
ILE A  44
 None
 1.01A 3h0aA-5c90A:
undetectable		 3h0aA-5c90A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		4 / 6 GLN A  82
TYR A  78
PHE A 102
LEU A 154
 None
None
None
MPD  A2001 ( 4.8A)
 1.44A 3tgvB-5c90A:
undetectable		 3tgvB-5c90A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		5 / 10 ILE A  30
ILE A  29
ILE A  91
ILE A  64
ILE A  93
 None
 1.03A 5murE-5c90A:
undetectable		 5murE-5c90A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		4 / 7 GLN A 160
GLY A 184
GLN A  82
TYR A  78
 None
 1.14A 5vlmE-5c90A:
undetectable		 5vlmE-5c90A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		4 / 4 GLN A  82
THR A  80
THR A  72
LEU A 103
 None
 1.19A 6f3mA-5c90A:
undetectable		 6f3mA-5c90A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 5c90 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Staphylococcus
aureus) 		4 / 4 GLN A  82
THR A  80
THR A  72
LEU A 103
 None
 1.19A 6f3mC-5c90A:
undetectable		 6f3mC-5c90A:
18.65