SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		3 / 3 VAL A 588
ALA A 589
HIS A 648
 None
 0.72A 1q23L-5c91A:
undetectable		 1q23L-5c91A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		3 / 3 VAL A 588
ALA A 589
HIS A 648
 None
 0.64A 1q23J-5c91A:
undetectable		 1q23J-5c91A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 7 GLY A 643
PHE A 752
ILE A 638
PHE A 660
 None
 1.00A 2qmzA-5c91A:
undetectable
2qmzB-5c91A:
undetectable		 2qmzA-5c91A:
19.28
2qmzB-5c91A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 7 GLY A 654
GLY A 643
PHE A 752
PHE A 660
 None
 0.95A 2qwxA-5c91A:
undetectable
2qwxB-5c91A:
undetectable		 2qwxA-5c91A:
19.53
2qwxB-5c91A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		3 / 3 LEU A 773
MET A 777
MET A 835
 None
 0.95A 2vavF-5c91A:
undetectable		 2vavF-5c91A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 6 TYR A 661
PHE A 660
PHE A 608
PHE A 601
 None
 1.46A 3af3A-5c91A:
undetectable		 3af3A-5c91A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		3 / 3 GLU A 774
SER A 676
VAL A 677
 None
 0.79A 3eeoA-5c91A:
undetectable		 3eeoA-5c91A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 6 MET A 663
ILE A 745
ARG A 744
VAL A 677
 None
 1.41A 4mk4B-5c91A:
undetectable		 4mk4B-5c91A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 6 LEU A 780
ARG A 658
ASP A 769
VAL A 646
 None
 0.81A 4nkxA-5c91A:
undetectable		 4nkxA-5c91A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 12 TYR A 661
ILE A 765
PHE A 752
GLY A 643
LEU A 652
 None
 1.24A 4zdyA-5c91A:
undetectable		 4zdyA-5c91A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 12 TYR A 661
ILE A 765
PHE A 752
GLY A 643
LEU A 652
 None
 1.43A 5v5zA-5c91A:
undetectable		 5v5zA-5c91A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 7 PHE A 529
GLY A 643
LEU A 651
GLY A 779
 None
 0.81A 6eu9D-5c91A:
undetectable		 6eu9D-5c91A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		3 / 3 PHE A 868
ARG A 870
GLN A 848
 None
 1.13A 6g1pB-5c91A:
undetectable		 6g1pB-5c91A:
20.30