SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 8 LEU A  98
PHE A 100
ASP A  79
LEU A  78
None
1.01A 1e7cA-5c92A:
undetectable
1e7cA-5c92A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.20A 1jhoA-5c92A:
undetectable
1jhoA-5c92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.17A 1jhrA-5c92A:
undetectable
1jhrA-5c92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.16A 1jhyA-5c92A:
undetectable
1jhyA-5c92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.18A 1l4nA-5c92A:
undetectable
1l4nA-5c92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.16A 1l5kA-5c92A:
undetectable
1l5kA-5c92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.18A 1l5lA-5c92A:
undetectable
1l5lA-5c92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.17A 1l5mA-5c92A:
undetectable
1l5mA-5c92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 ASP A 377
GLY A 378
THR A 380
PRO A 381
None
0.73A 1n4fA-5c92A:
undetectable
1n4fA-5c92A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 ASP A  81
GLY A 129
LEU A 482
TYR A 461
ILE A 457
None
1.42A 1sq5A-5c92A:
undetectable
1sq5A-5c92A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 10 ASP A  81
GLY A 129
LEU A 482
TYR A 461
ILE A 457
None
1.43A 1sq5B-5c92A:
undetectable
1sq5B-5c92A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 ASP A  81
GLY A 129
LEU A 482
TYR A 461
ILE A 457
None
1.43A 1sq5C-5c92A:
0.0
1sq5C-5c92A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 10 ASP A  81
GLY A 129
LEU A 482
TYR A 461
ILE A 457
None
1.42A 1sq5D-5c92A:
undetectable
1sq5D-5c92A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 LEU A  28
LEU A  21
SER A 419
THR A 421
None
1.13A 1tyrA-5c92A:
1.9
1tyrA-5c92A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 GLY A 279
SER A 250
GLY A 242
MET A 222
VAL A 294
None
1.07A 2b25B-5c92A:
undetectable
2b25B-5c92A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
3 / 3 SER A 127
ASP A 202
CYH A 162
None
NAG  A 502 (-3.2A)
None
0.95A 2br4E-5c92A:
undetectable
2br4E-5c92A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 THR A 238
TYR A 239
GLY A 242
GLY A 224
GLY A 247
None
0.85A 2fk8A-5c92A:
undetectable
2fk8A-5c92A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 PRO A 211
LEU A 214
LYS A 197
GLY A 193
None
1.01A 2hs2B-5c92A:
undetectable
2hs2B-5c92A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 7 MET A 198
ILE A 236
GLY A 224
MET A 222
None
0.98A 2pnjB-5c92A:
undetectable
2pnjB-5c92A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 SER A 226
ARG A 215
PRO A 194
GLY A 193
None
1.34A 2y7pA-5c92A:
undetectable
2y7pA-5c92A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 ASP A 343
LEU A  28
LEU A  21
GLY A  26
PHE A 464
ACT  A 504 (-3.2A)
None
None
None
None
1.22A 2zj0C-5c92A:
undetectable
2zj0C-5c92A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 TYR A 334
MET A 173
PHE A 174
PHE A 138
CU1  A 503 (-4.3A)
None
None
None
1.15A 3af3A-5c92A:
undetectable
3af3A-5c92A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 TRP A 292
HIS A 362
ASP A 364
GLN A 366
PRO A 312
None
1.49A 3b7pA-5c92A:
undetectable
3b7pA-5c92A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 5 VAL A  19
VAL A  30
GLN A  65
PHE A  72
None
None
None
CU1  A 503 (-4.4A)
1.10A 3bjwH-5c92A:
undetectable
3bjwH-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 VAL A  19
VAL A  30
GLN A  65
PHE A  72
None
None
None
CU1  A 503 (-4.4A)
1.16A 3bjwF-5c92A:
undetectable
3bjwF-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 5 VAL A  19
VAL A  30
GLN A  65
PHE A  72
None
None
None
CU1  A 503 (-4.4A)
1.07A 3bjwB-5c92A:
undetectable
3bjwB-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 ASP A 343
LEU A  28
LEU A  21
GLY A  26
PHE A 464
ACT  A 504 (-3.2A)
None
None
None
None
1.28A 3glqA-5c92A:
undetectable
3glqA-5c92A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 4 LEU A 340
ALA A 475
VAL A 474
PRO A 472
None
1.24A 3gv1B-5c92A:
undetectable
3gv1B-5c92A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 4 GLN A 298
GLN A 309
GLY A 295
HIS A 328
None
1.42A 3huoA-5c92A:
undetectable
3huoA-5c92A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 ASP A 343
LEU A  28
LEU A  21
GLY A  26
PHE A 464
ACT  A 504 (-3.2A)
None
None
None
None
1.29A 3n58A-5c92A:
undetectable
3n58A-5c92A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 ASP A 343
LEU A  28
LEU A  21
GLY A  26
PHE A 464
ACT  A 504 (-3.2A)
None
None
None
None
1.28A 3n58C-5c92A:
undetectable
3n58C-5c92A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 7 TRP A 184
ILE A 457
THR A 125
VAL A 232
None
1.35A 4iarA-5c92A:
undetectable
4iarA-5c92A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 9 GLY A 296
GLY A 242
SER A 250
ARG A 278
GLY A 224
None
1.19A 4kqiA-5c92A:
undetectable
4kqiA-5c92A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 THR A  49
THR A  47
THR A  76
LEU A  29
None
1.05A 4pgfA-5c92A:
undetectable
4pgfA-5c92A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 LEU A 463
ALA A 475
PHE A 464
ARG A 417
LEU A 340
None
1.08A 5nd4B-5c92A:
undetectable
5nd4B-5c92A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 5 VAL A 293
ARG A 278
GLY A 274
TYR A 276
None
1.18A 5x80A-5c92A:
undetectable
5x80B-5c92A:
undetectable
5x80A-5c92A:
15.37
5x80B-5c92A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 5 GLY A 274
TYR A 276
VAL A 293
ARG A 278
None
1.20A 5x80C-5c92A:
undetectable
5x80D-5c92A:
undetectable
5x80C-5c92A:
15.37
5x80D-5c92A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 8 GLY A 146
CYH A 124
SER A 122
ALA A 179
None
0.88A 5xu8A-5c92A:
undetectable
5xu8A-5c92A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
4 / 6 ARG A 118
GLY A 135
THR A 143
VAL A 164
None
1.24A 5ysiA-5c92A:
undetectable
5ysiA-5c92A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 ASP A 343
LEU A  28
LEU A  21
GLY A  26
PHE A 464
ACT  A 504 (-3.2A)
None
None
None
None
1.29A 6f3nC-5c92A:
undetectable
6f3nC-5c92A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola)
5 / 12 ASP A 288
PHE A 464
ASN A   2
ARG A 384
PRO A 370
None
1.40A 6gnfA-5c92A:
undetectable
6gnfA-5c92A:
22.39