SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 12 ILE A 331
LEU A 139
GLY A 165
VAL A 149
ALA A 148
 None
 1.05A 1tlsA-5c98A:
undetectable		 1tlsA-5c98A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 12 ILE A 331
LEU A 139
GLY A 165
VAL A 149
ALA A 148
 None
 1.12A 1tlsB-5c98A:
undetectable		 1tlsB-5c98A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 10 LEU A 251
PHE A 357
LEU A 227
ASP A 237
LEU A 278
 None
 1.13A 1yi4A-5c98A:
undetectable		 1yi4A-5c98A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 9 LEU A 259
ALA A 359
LEU A 287
GLU A 202
LEU A 203
 None
 1.20A 2azqA-5c98A:
undetectable		 2azqA-5c98A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 10 SER A 145
LEU A 111
ASP A 138
ASP A 141
GLU A 113
 None
 1.45A 2j1gE-5c98A:
undetectable
2j1gF-5c98A:
undetectable		 2j1gE-5c98A:
20.28
2j1gF-5c98A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 8 SER A 145
LEU A 111
ASP A 138
ASP A 141
GLU A 113
 None
 1.34A 2j2pA-5c98A:
undetectable
2j2pB-5c98A:
undetectable		 2j2pA-5c98A:
20.28
2j2pB-5c98A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 9 SER A 171
SER A 145
LEU A 111
ASP A 138
GLU A 113
 None
 1.37A 2j2pD-5c98A:
undetectable
2j2pE-5c98A:
undetectable		 2j2pD-5c98A:
20.28
2j2pE-5c98A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		4 / 5 PHE A 365
PHE A 363
PHE A 204
VAL A 292
 None
 1.21A 2lh6A-5c98A:
undetectable		 2lh6A-5c98A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		4 / 4 ALA A  66
VAL A 310
PHE A  62
THR A 325
 None
 1.24A 2pkkA-5c98A:
undetectable		 2pkkA-5c98A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 12 LEU A 178
THR A 325
PHE A 122
GLU A 123
SER A 322
 None
 1.41A 2ydoA-5c98A:
undetectable		 2ydoA-5c98A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		4 / 5 GLN A 131
PHE A 130
LEU A 180
PHE A 330
 None
 1.24A 3ablC-5c98A:
undetectable
3ablJ-5c98A:
undetectable		 3ablC-5c98A:
20.20
3ablJ-5c98A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		4 / 5 ASP A 168
ILE A 160
ILE A 331
GLY A 165
 None
 0.88A 3bufA-5c98A:
undetectable		 3bufA-5c98A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 12 GLY A 303
LEU A 305
PHE A 311
ALA A  77
PHE A  33
 None
 0.95A 3gwwA-5c98A:
undetectable		 3gwwA-5c98A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		5 / 9 ALA A  40
MET A 364
PHE A 365
LEU A 366
THR A 301
 None
 1.44A 4eilF-5c98A:
undetectable		 4eilF-5c98A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		4 / 7 PHE A 381
PHE A 363
PHE A 206
LEU A 287
 None
 1.04A 4ejgA-5c98A:
undetectable		 4ejgA-5c98A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		3 / 3 LYS A 286
HIS A 218
HIS A 358
 None
 1.32A 5oexA-5c98A:
undetectable		 5oexA-5c98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		3 / 3 LYS A 286
HIS A 218
HIS A 358
 None
 1.35A 5oexB-5c98A:
undetectable		 5oexB-5c98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		3 / 3 LYS A 286
HIS A 218
HIS A 358
 None
 1.34A 5oexC-5c98A:
undetectable		 5oexC-5c98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		3 / 3 LYS A 286
HIS A 218
HIS A 358
 None
 1.34A 5oexD-5c98A:
undetectable		 5oexD-5c98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 5c98 AGAP007691-PB
(Anopheles
gambiae) 		4 / 6 CYH A 233
PHE A 357
LEU A 278
SER A 247
 None
 1.26A 6a7pB-5c98A:
undetectable		 6a7pB-5c98A:
21.03