SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		5 / 12 ASP A 140
GLY A 142
ALA A 143
ASP A 145
ILE A 206
 None
 0.82A 1hshC-5c9dA:
8.7		 1hshC-5c9dA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 6 LEU A 148
THR A 149
PHE A 137
LEU A 208
 None
 0.89A 2wm3A-5c9dA:
undetectable		 2wm3A-5c9dA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 8 ASP A 140
GLY A 142
ALA A 143
ASP A 145
 None
 0.45A 3el0A-5c9dA:
8.5		 3el0A-5c9dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		5 / 9 ASP A 140
GLY A 142
ALA A 143
ASP A 145
ILE A 206
 None
 0.77A 3s53A-5c9dA:
8.6		 3s53A-5c9dA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 7 ASP A 140
GLY A 142
ALA A 143
ASP A 145
 None
 0.42A 3t3cA-5c9dA:
9.2		 3t3cA-5c9dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 7 LEU A 156
GLN A 154
PHE A 158
LEU A 183
 None
 0.95A 3x2qC-5c9dA:
undetectable
3x2qJ-5c9dA:
undetectable		 3x2qC-5c9dA:
17.54
3x2qJ-5c9dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 7 LEU A 156
GLN A 154
PHE A 158
LEU A 183
 None
 0.95A 3x2qP-5c9dA:
undetectable
3x2qW-5c9dA:
undetectable		 3x2qP-5c9dA:
17.54
3x2qW-5c9dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		5 / 12 ASP A 140
GLY A 142
ALA A 143
ASP A 145
ILE A 206
 None
 0.71A 5e5jA-5c9dA:
8.5		 5e5jA-5c9dA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 7 ARG A 216
LEU A 229
PHE A 220
THR A 141
 None
 1.02A 5vc0A-5c9dA:
undetectable		 5vc0A-5c9dA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 5 LYS A 150
ALA A 153
LEU A 156
LEU A 160
 None
 0.74A 5vkqA-5c9dA:
undetectable
5vkqD-5c9dA:
undetectable		 5vkqA-5c9dA:
6.18
5vkqD-5c9dA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 5 LEU A 160
LYS A 150
ALA A 153
LEU A 156
 None
 0.77A 5vkqA-5c9dA:
undetectable
5vkqB-5c9dA:
undetectable		 5vkqA-5c9dA:
6.18
5vkqB-5c9dA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 5 LEU A 160
LYS A 150
ALA A 153
LEU A 156
 None
 0.74A 5vkqB-5c9dA:
undetectable
5vkqC-5c9dA:
undetectable		 5vkqB-5c9dA:
6.18
5vkqC-5c9dA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 5 LEU A 160
LYS A 150
ALA A 153
LEU A 156
 None
 0.79A 5vkqC-5c9dA:
undetectable
5vkqD-5c9dA:
undetectable		 5vkqC-5c9dA:
6.18
5vkqD-5c9dA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 7 LEU A 156
GLN A 154
PHE A 158
LEU A 183
 None
 0.96A 5z85C-5c9dA:
undetectable
5z85J-5c9dA:
undetectable		 5z85C-5c9dA:
17.54
5z85J-5c9dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 7 LEU A 156
GLN A 154
PHE A 158
LEU A 183
 None
 0.93A 5zcoC-5c9dA:
undetectable
5zcoJ-5c9dA:
undetectable		 5zcoC-5c9dA:
17.54
5zcoJ-5c9dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 7 LEU A 156
GLN A 154
PHE A 158
LEU A 183
 None
 0.93A 5zcqP-5c9dA:
undetectable
5zcqW-5c9dA:
undetectable		 5zcqP-5c9dA:
17.54
5zcqW-5c9dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		5 / 12 ASP A 140
GLY A 142
ALA A 143
ASP A 145
ILE A 206
 None
 0.72A 6dh3A-5c9dA:
8.7		 6dh3A-5c9dA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9d APRICK PROTEASE
(Rickettsia
conorii) 		4 / 5 LEU A 156
GLN A 154
PHE A 158
PHE A 137
 None
 1.21A 6nmpP-5c9dA:
undetectable
6nmpW-5c9dA:
undetectable		 6nmpP-5c9dA:
17.54
6nmpW-5c9dA:
21.05