SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c9e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5c9e SEPL
(Escherichia
coli) 		6 / 11 LEU A 167
LEU A 154
LEU A 137
SER A 135
ILE A 100
ALA A 131
 None
 1.24A 1ha2A-5c9eA:
3.1		 1ha2A-5c9eA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5c9e SEPL
(Escherichia
coli) 		4 / 7 ILE A 328
LEU A 315
ILE A 276
ILE A 303
 None
 0.84A 1uwjA-5c9eA:
undetectable		 1uwjA-5c9eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5c9e SEPL
(Escherichia
coli) 		6 / 12 LEU A 167
LEU A 154
LEU A 137
SER A 135
ILE A 100
ALA A 131
 None
 1.31A 2bxqA-5c9eA:
2.9		 2bxqA-5c9eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.85A 2eijN-5c9eA:
undetectable
2eijW-5c9eA:
undetectable		 2eijN-5c9eA:
19.39
2eijW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5c9e SEPL
(Escherichia
coli) 		4 / 7 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.83A 2eikA-5c9eA:
2.1
2eikJ-5c9eA:
undetectable		 2eikA-5c9eA:
19.39
2eikJ-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.88A 2eilN-5c9eA:
undetectable
2eilW-5c9eA:
undetectable		 2eilN-5c9eA:
19.39
2eilW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5c9e SEPL
(Escherichia
coli) 		4 / 7 ILE A 254
SER A 321
TYR A 261
CYH A 326
 None
 1.41A 2xz5D-5c9eA:
undetectable
2xz5E-5c9eA:
undetectable		 2xz5D-5c9eA:
21.96
2xz5E-5c9eA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.80A 3ablN-5c9eA:
1.8
3ablW-5c9eA:
undetectable		 3ablN-5c9eA:
19.39
3ablW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.84A 3ag3N-5c9eA:
3.1
3ag3W-5c9eA:
undetectable		 3ag3N-5c9eA:
19.39
3ag3W-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.87A 3asnN-5c9eA:
2.9
3asnW-5c9eA:
undetectable		 3asnN-5c9eA:
19.39
3asnW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5c9e SEPL
(Escherichia
coli) 		5 / 12 SER A 227
ILE A 223
LEU A 249
LEU A 168
LEU A  94
 None
 1.33A 3cs8A-5c9eA:
undetectable		 3cs8A-5c9eA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5c9e SEPL
(Escherichia
coli) 		4 / 7 LEU A 167
ILE A 100
THR A  95
GLY A 172
 None
 0.80A 4eq4A-5c9eA:
undetectable		 4eq4A-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 167
ILE A 100
THR A  95
GLY A 172
 None
 0.77A 4eq4B-5c9eA:
undetectable		 4eq4B-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5c9e SEPL
(Escherichia
coli) 		4 / 7 LEU A 167
ILE A 100
THR A  95
GLY A 172
 None
 0.77A 4eqlA-5c9eA:
undetectable		 4eqlA-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5c9e SEPL
(Escherichia
coli) 		4 / 7 LEU A 167
ILE A 100
THR A  95
GLY A 172
 None
 0.75A 4eqlB-5c9eA:
undetectable		 4eqlB-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5c9e SEPL
(Escherichia
coli) 		4 / 6 LEU A 167
ILE A 100
THR A  95
GLY A 172
 None
 0.76A 4l39A-5c9eA:
1.6		 4l39A-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5c9e SEPL
(Escherichia
coli) 		4 / 7 LEU A 167
ILE A 100
THR A  95
GLY A 172
 None
 0.72A 4l39B-5c9eA:
undetectable		 4l39B-5c9eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5c9e SEPL
(Escherichia
coli) 		5 / 12 SER A 231
ASN A  86
GLN A  89
GLU A  90
LEU A  94
 None
 1.22A 5nwwA-5c9eA:
undetectable		 5nwwA-5c9eA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5c9e SEPL
(Escherichia
coli) 		5 / 12 SER A 231
ASN A  86
GLN A  89
LEU A  91
LEU A  94
 None
 1.20A 5nwwA-5c9eA:
undetectable		 5nwwA-5c9eA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.82A 5xdxN-5c9eA:
2.4
5xdxW-5c9eA:
undetectable		 5xdxN-5c9eA:
19.39
5xdxW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5c9e SEPL
(Escherichia
coli) 		3 / 3 ASP A 272
PHE A 206
ARG A 215
 None
 1.03A 5yw0A-5c9eA:
undetectable		 5yw0A-5c9eA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.84A 5zcoA-5c9eA:
2.8
5zcoJ-5c9eA:
undetectable		 5zcoA-5c9eA:
19.39
5zcoJ-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5c9e SEPL
(Escherichia
coli) 		4 / 8 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.84A 5zcqN-5c9eA:
2.4
5zcqW-5c9eA:
undetectable		 5zcqN-5c9eA:
19.39
5zcqW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5c9e SEPL
(Escherichia
coli) 		5 / 12 LEU A 202
SER A 297
VAL A 301
ASP A 274
ASP A 272
 None
 1.45A 6bxnA-5c9eA:
undetectable		 6bxnA-5c9eA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5c9e SEPL
(Escherichia
coli) 		3 / 3 LEU A 219
LEU A 256
ARG A 215
 None
 0.61A 6fgcA-5c9eA:
undetectable		 6fgcA-5c9eA:
21.97