SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5c9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5c9s RRNA BIOGENESIS
PROTEIN RRP5
(Saccharomyces
cerevisiae) 		4 / 8 ASN B1525
ILE B1556
PHE B1537
TYR B1557
 None
 1.44A 3ccfB-5c9sB:
undetectable		 3ccfB-5c9sB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5c9s RRNA BIOGENESIS
PROTEIN RRP5
(Saccharomyces
cerevisiae) 		3 / 3 LYS B1650
PRO B1649
LYS B1682
 None
 1.17A 4dv7L-5c9sB:
undetectable		 4dv7L-5c9sB:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5c9s RRNA BIOGENESIS
PROTEIN RRP5
(Saccharomyces
cerevisiae) 		3 / 3 LYS B1631
LEU B1627
ALA B1630
 None
 0.67A 4iizA-5c9sB:
undetectable		 4iizA-5c9sB:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5c9s RRNA BIOGENESIS
PROTEIN RRP5
(Saccharomyces
cerevisiae) 		3 / 3 TRP B1478
MET B1479
ASN B1480
 None
 0.97A 5uc1B-5c9sB:
undetectable		 5uc1B-5c9sB:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5c9s RRNA BIOGENESIS
PROTEIN RRP5
(Saccharomyces
cerevisiae) 		3 / 3 TRP B1478
MET B1479
ASN B1480
 None
 0.90A 5uc1A-5c9sB:
undetectable		 5uc1A-5c9sB:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5c9s RRNA BIOGENESIS
PROTEIN RRP5
(Saccharomyces
cerevisiae) 		5 / 6 PHE B1624
ARG B1622
LEU B1627
ALA B1601
GLN B1661
 None
GOL  B1801 (-4.7A)
None
None
None
 1.33A 6b89B-5c9sB:
undetectable		 6b89B-5c9sB:
9.34