SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ca5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		5 / 10 ALA A 153
PHE A 154
GLY A 121
GLU A 129
LEU A 147
 None
 1.42A 1cmcA-5ca5A:
undetectable
1cmcB-5ca5A:
undetectable		 1cmcA-5ca5A:
18.99
1cmcB-5ca5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		5 / 12 GLY A 151
LEU A 118
GLY A 121
ILE A 170
LEU A 155
 None
 0.98A 2nxeB-5ca5A:
3.5		 2nxeB-5ca5A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		5 / 12 GLY A 151
LEU A 118
GLY A 121
ILE A 170
LEU A 155
 None
 1.03A 2zbpA-5ca5A:
3.5		 2zbpA-5ca5A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		4 / 6 GLY A 151
PRO A 124
ASN A 125
GLY A 177
 None
 0.83A 4fjpA-5ca5A:
undetectable		 4fjpA-5ca5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		4 / 6 ARG A 160
GLU A 168
ASP A 274
ASP A 272
 None
 1.40A 4kcnA-5ca5A:
undetectable		 4kcnA-5ca5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		4 / 6 ARG A 160
GLU A 168
ASP A 274
ASP A 272
 None
 1.40A 4kcnB-5ca5A:
undetectable		 4kcnB-5ca5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 135
ALA A 166
PHE A 136
ILE A 175
VAL A 120
 None
 0.99A 4nkvD-5ca5A:
undetectable		 4nkvD-5ca5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		3 / 3 GLU A 203
LYS A 106
ASN A 202
 None
 0.79A 4y1dA-5ca5A:
undetectable
4y1dD-5ca5A:
undetectable		 4y1dA-5ca5A:
20.85
4y1dD-5ca5A:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5ca5 NONO-1
(Caenorhabditis
elegans) 		4 / 5 ASP A 158
GLU A 235
ARG A 160
THR A 113
 None
 1.35A 5uxcA-5ca5A:
undetectable		 5uxcA-5ca5A:
25.00