SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5caa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		3 / 3 GLU A 123
ALA A 125
SER A 119
 None
 0.67A 1errB-5caaA:
undetectable		 1errB-5caaA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		4 / 6 ALA A  47
TYR A  66
ILE A  72
PRO A  42
 None
 1.17A 1oniB-5caaA:
undetectable
1oniC-5caaA:
undetectable		 1oniB-5caaA:
24.14
1oniC-5caaA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		4 / 6 ALA A  47
TYR A  66
ILE A  72
PRO A  42
 None
 1.16A 1oniH-5caaA:
undetectable
1oniI-5caaA:
undetectable		 1oniH-5caaA:
24.14
1oniI-5caaA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		4 / 5 LEU A  90
GLY A 105
GLU A  22
CYH A 116
 None
 1.23A 3aiaA-5caaA:
undetectable
3aiaB-5caaA:
undetectable		 3aiaA-5caaA:
25.58
3aiaB-5caaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		5 / 12 ILE A 103
PRO A  95
PHE A 107
ILE A   8
ALA A   9
 None
 1.07A 3jb1A-5caaA:
undetectable		 3jb1A-5caaA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		3 / 3 ARG A  87
GLU A   4
TYR A  32
 None
 0.87A 3k37B-5caaA:
undetectable		 3k37B-5caaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		5 / 12 SER A 124
ARG A 127
ALA A  47
GLY A  49
TYR A  51
 None
 1.14A 4r29B-5caaA:
undetectable		 4r29B-5caaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		4 / 5 CYH A  74
ILE A  72
HIS A  50
HIS A 117
 None
 1.21A 5ocsA-5caaA:
undetectable		 5ocsA-5caaA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		3 / 3 HIS A  50
GLU A 128
TRP A 132
 None
 1.19A 5odiD-5caaA:
undetectable		 5odiD-5caaA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5caa NUCLEOSIDE
DIPHOSPHATE KINASE
(Leishmania
major) 		3 / 3 HIS A  50
GLU A 128
TRP A 132
 None
 1.22A 5odrD-5caaA:
undetectable		 5odrD-5caaA:
17.18