SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
3 / 3 LYS A  89
GLY A 210
PRO A 211
None
0.99A 2hreB-5cadA:
undetectable
2hreB-5cadA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 8 GLY A 338
ALA A 244
ASP A 243
ILE A  72
None
0.64A 3el0A-5cadA:
undetectable
3el0A-5cadA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 LEU A 101
PHE A  73
SER A 107
ILE A 109
LEU A 111
None
PCA  A 403 ( 4.8A)
None
None
None
1.15A 3ia4C-5cadA:
undetectable
3ia4C-5cadA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 LEU A 101
PHE A  73
SER A 107
ILE A 109
LEU A 111
None
PCA  A 403 ( 4.8A)
None
None
None
1.19A 3ia4D-5cadA:
undetectable
3ia4D-5cadA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)
5cad SM80.1 VICILIN
(Solanum
melongena)
3 / 3 LYS A  97
ILE A 251
PHE A 225
None
0.91A 3j7zS-5cadA:
undetectable
3j7za-5cadA:
undetectable
3j7zS-5cadA:
15.62
3j7za-5cadA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 GLY A 338
ALA A 244
ASP A 243
VAL A 100
ALA A 247
None
None
None
None
ACT  A 402 ( 3.8A)
0.96A 3n3iA-5cadA:
undetectable
3n3iA-5cadA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
3 / 3 ALA A 389
VAL A 388
GLN A 382
None
0.66A 3of4B-5cadA:
undetectable
3of4B-5cadA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 ILE A  72
GLY A 336
ALA A 247
PHE A 248
ALA A 231
None
None
ACT  A 402 ( 3.8A)
None
None
1.02A 3sudB-5cadA:
undetectable
3sudB-5cadA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
None
1.02A 4e1gA-5cadA:
undetectable
4e1gA-5cadA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
None
1.05A 4e1gB-5cadA:
undetectable
4e1gB-5cadA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 4 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.29A 4f3tA-5cadA:
undetectable
4f3tA-5cadA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 5 ILE A  72
LEU A 125
ASP A 243
GLU A  70
None
1.04A 4nkxB-5cadA:
undetectable
4nkxB-5cadA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 ILE A 109
HIS A  65
ILE A  54
PHE A  30
MET A  62
None
PCA  A 403 (-3.9A)
None
PCA  A 403 (-4.1A)
PCA  A 403 ( 4.9A)
1.05A 4rp8C-5cadA:
undetectable
4rp8C-5cadA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 5 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.27A 4w5oA-5cadA:
undetectable
4w5oA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 4 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.27A 4w5rA-5cadA:
undetectable
4w5rA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 4 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.29A 4w5tA-5cadA:
undetectable
4w5tA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 5 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.28A 4z4cA-5cadA:
undetectable
4z4cA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 5 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.28A 4z4dA-5cadA:
undetectable
4z4dA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 5 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.26A 4z4eA-5cadA:
undetectable
4z4eA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 4 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.30A 4z4gA-5cadA:
undetectable
4z4gA-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 6 ILE A  72
HIS A  65
ILE A  84
VAL A 208
None
PCA  A 403 (-3.9A)
None
None
0.79A 4zj8A-5cadA:
undetectable
4zj8A-5cadA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 6 PHE A 228
ALA A 247
ASN A 344
ARG A 267
ACT  A 402 (-4.8A)
ACT  A 402 ( 3.8A)
None
ACT  A 402 (-3.9A)
1.23A 5cadA-5cadA:
62.9
5cadA-5cadA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)
5cad SM80.1 VICILIN
(Solanum
melongena)
6 / 6 PHE A 228
ALA A 247
TYR A 260
ASN A 262
ARG A 267
LYS A 346
ACT  A 402 (-4.8A)
ACT  A 402 ( 3.8A)
ACT  A 402 (-4.5A)
ACT  A 402 (-3.3A)
ACT  A 402 (-3.9A)
ACT  A 402 (-2.9A)
0.00A 5cadA-5cadA:
62.9
5cadA-5cadA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 12 LEU A  33
VAL A  53
PHE A  19
VAL A 271
GLY A 336
None
1.44A 5i8fA-5cadA:
undetectable
5i8fA-5cadA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 4 PHE A 337
VAL A  51
ALA A 270
PHE A  19
None
1.28A 5ki6A-5cadA:
undetectable
5ki6A-5cadA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 6 LEU A 349
TRP A 356
ARG A 357
GLY A 351
None
1.10A 5o4yA-5cadA:
undetectable
5o4yA-5cadA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)
5cad SM80.1 VICILIN
(Solanum
melongena)
4 / 6 LEU A 349
TRP A 356
ARG A 357
GLY A 351
None
1.02A 5o4yF-5cadA:
undetectable
5o4yF-5cadA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
7 / 11 GLY A 336
MET A 249
TYR A 260
ASN A 262
ARG A 267
PHE A 324
LYS A 346
None
None
ACT  A 402 (-4.5A)
ACT  A 402 (-3.3A)
ACT  A 402 (-3.9A)
None
ACT  A 402 (-2.9A)
1.20A 5yjsA-5cadA:
51.0
5yjsA-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
9 / 11 PHE A 228
MET A 249
TYR A 260
ASN A 262
ARG A 267
VAL A 269
PHE A 324
GLY A 336
LYS A 346
ACT  A 402 (-4.8A)
None
ACT  A 402 (-4.5A)
ACT  A 402 (-3.3A)
ACT  A 402 (-3.9A)
None
None
None
ACT  A 402 (-2.9A)
0.31A 5yjsA-5cadA:
51.0
5yjsA-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 11 PHE A 228
TYR A 260
VAL A 334
PHE A 324
LYS A 346
ACT  A 402 (-4.8A)
ACT  A 402 (-4.5A)
None
None
ACT  A 402 (-2.9A)
1.50A 5yjsA-5cadA:
51.0
5yjsA-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_B_SALB601_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
9 / 9 PHE A 228
MET A 249
TYR A 260
ASN A 262
ARG A 267
VAL A 269
PHE A 324
GLY A 336
LYS A 346
ACT  A 402 (-4.8A)
None
ACT  A 402 (-4.5A)
ACT  A 402 (-3.3A)
ACT  A 402 (-3.9A)
None
None
None
ACT  A 402 (-2.9A)
0.34A 5yjsB-5cadA:
51.0
5yjsB-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_B_SALB601_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)
5cad SM80.1 VICILIN
(Solanum
melongena)
5 / 9 PHE A 228
TYR A 260
VAL A 334
PHE A 324
LYS A 346
ACT  A 402 (-4.8A)
ACT  A 402 (-4.5A)
None
None
ACT  A 402 (-2.9A)
1.49A 5yjsB-5cadA:
51.0
5yjsB-5cadA:
13.54