SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5caj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		5 / 9 GLU A  98
ARG A  21
ALA A  79
ILE A  80
THR A  18
 None
 1.38A 1aj6A-5cajA:
undetectable		 1aj6A-5cajA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		5 / 9 GLY A  -2
ALA A 158
SER A  -1
LEU A 159
HIS A 107
 None
 1.37A 1y7iA-5cajA:
undetectable		 1y7iA-5cajA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		5 / 9 LEU A 135
ILE A 133
GLY A 132
SER A  31
LEU A 114
 None
 1.03A 2qmmA-5cajA:
undetectable		 2qmmA-5cajA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		5 / 12 PHE A  83
GLY A  85
GLY A  90
LEU A  91
PRO A   7
 None
 0.88A 3av6A-5cajA:
undetectable		 3av6A-5cajA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		6 / 12 VAL A 179
LEU A 108
LEU A 155
TYR A  88
ALA A 171
LEU A 111
 None
 1.22A 3n8wA-5cajA:
undetectable		 3n8wA-5cajA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		3 / 3 LYS A 182
LYS A 180
PRO A 181
 None
 1.08A 4dv1L-5cajA:
undetectable		 4dv1L-5cajA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		5 / 12 PHE A  83
GLY A 113
GLY A 116
ASN A  30
LEU A 129
 None
 1.09A 6b3aA-5cajA:
undetectable		 6b3aA-5cajA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		5 / 12 PHE A  83
GLY A 113
GLY A 116
ASN A  30
LEU A 129
 None
 1.09A 6b3bA-5cajA:
undetectable		 6b3bA-5cajA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		5 / 12 PHE A  83
GLY A 113
GLY A 116
ILE A 133
LEU A 129
 None
 1.15A 6b3bA-5cajA:
undetectable		 6b3bA-5cajA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5caj UPF0246 PROTEIN YAAA
(Escherichia
coli) 		4 / 8 ILE A 133
VAL A 117
LYS A 154
SER A   6
 None
None
None
CL  A 301 (-3.3A)
 1.11A 6fbvC-5cajA:
undetectable		 6fbvC-5cajA:
12.16