SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A  72
THR A  98
LEU A  73
VAL A  95
 None
 0.80A 1sn5C-5cb6A:
undetectable		 1sn5C-5cb6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A  72
THR A  98
LEU A  73
VAL A  95
 None
 0.74A 4ik6B-5cb6A:
undetectable		 4ik6B-5cb6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A  72
THR A  98
LEU A  73
VAL A  95
 None
 0.78A 4ik7B-5cb6A:
undetectable		 4ik7B-5cb6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  63
LEU A  39
THR A  98
ILE A  99
THR A  49
 None
 1.15A 5z6fA-5cb6A:
undetectable		 5z6fA-5cb6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  12
LEU A  13
GLY A  15
ILE A   8
ASN A 108
 None
None
ANP  A 302 (-3.3A)
None
None
 0.98A 6mhtA-5cb6A:
undetectable		 6mhtA-5cb6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 HIS A  23
ARG A  30
GLU A  26
GLU A  37
 None
 1.05A 6mn4D-5cb6A:
undetectable		 6mn4D-5cb6A:
21.35