SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 9 PHE A 354
THR A 465
LEU A 466
VAL A 372
GLY A 373
 None
 1.33A 1dz8B-5cbmA:
undetectable		 1dz8B-5cbmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 9 PHE A 354
THR A 465
LEU A 466
VAL A 372
GLY A 373
 None
 1.34A 1dz9B-5cbmA:
undetectable		 1dz9B-5cbmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 6 VAL A 372
GLY A 373
ALA A 469
LEU A 470
 None
 0.72A 1e7bB-5cbmA:
undetectable		 1e7bB-5cbmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 CYH A 403
LEU A 466
ALA A 469
LEU A 470
 None
 0.98A 1hwiB-5cbmA:
undetectable		 1hwiB-5cbmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 CYH A 403
LEU A 466
ALA A 469
LEU A 470
 None
 0.97A 1hwiC-5cbmA:
undetectable		 1hwiC-5cbmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 5 SER A 145
SER A 146
VAL A 132
PHE A 130
 None
 1.36A 1oipA-5cbmA:
undetectable		 1oipA-5cbmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 LEU A 297
LEU A 407
ALA A 410
LEU A 323
ILE A 101
 None
 1.04A 1s9pA-5cbmA:
undetectable		 1s9pA-5cbmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 SER A 391
ILE A 393
LEU A 385
GLY A 382
GLY A 381
 SO4  A 709 (-3.9A)
None
None
None
ZN  A 703 ( 4.8A)
 0.90A 1uakA-5cbmA:
2.6		 1uakA-5cbmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 5 ALA A 410
TYR A 411
ALA A 318
GLN A 296
 None
1PE  A 705 (-4.5A)
None
None
 1.10A 1xl6A-5cbmA:
undetectable
1xl6B-5cbmA:
undetectable		 1xl6A-5cbmA:
18.72
1xl6B-5cbmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 10 ALA A 313
ALA A 314
LEU A 357
LEU A 407
ALA A 410
 None
 1.01A 2bxgB-5cbmA:
undetectable		 2bxgB-5cbmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ILE A 369
ALA A 405
CYH A 409
VAL A 413
TYR A 287
 None
 1.23A 2g72B-5cbmA:
undetectable		 2g72B-5cbmA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 GLY A 408
ALA A 404
GLY A 402
LEU A 297
LEU A 321
 None
 1.04A 2nyuB-5cbmA:
undetectable		 2nyuB-5cbmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		6 / 12 SER A 427
GLY A 408
ALA A 404
GLY A 402
THR A 415
LEU A 321
 None
 1.44A 2nyuB-5cbmA:
undetectable		 2nyuB-5cbmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ILE A 484
ALA A 428
GLY A 375
GLY A 402
ASN A 352
 None
 0.86A 2okcB-5cbmA:
undetectable		 2okcB-5cbmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 SER A 391
ILE A 393
LEU A 385
GLY A 382
GLY A 381
 SO4  A 709 (-3.9A)
None
None
None
ZN  A 703 ( 4.8A)
 0.89A 3axzA-5cbmA:
3.3		 3axzA-5cbmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 6 ASP A 459
ILE A 547
ARG A 463
SER A 554
 ZN  A 703 ( 2.9A)
SO4  A 712 (-3.4A)
SO4  A 712 ( 2.7A)
SO4  A 712 (-4.2A)
 1.20A 3ckzA-5cbmA:
undetectable		 3ckzA-5cbmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 THR A 465
ASP A 399
LYS A 386
ASP A 459
LEU A 487
 None
ZN  A 702 ( 2.3A)
4ZN  A 704 ( 2.5A)
ZN  A 703 ( 2.9A)
CO3  A 701 ( 4.5A)
 1.33A 3glqB-5cbmA:
undetectable		 3glqB-5cbmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 ASP A 379
PHE A 398
SER A 391
 ZN  A 703 (-2.3A)
4ZN  A 704 (-4.9A)
SO4  A 709 (-3.9A)
 0.97A 3i5uB-5cbmA:
undetectable		 3i5uB-5cbmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 10 VAL A 206
LEU A 198
GLY A 191
VAL A 132
GLY A 193
 None
 1.22A 3ls4H-5cbmA:
undetectable		 3ls4H-5cbmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 9 ILE A 453
ALA A 467
ASP A 468
THR A 465
VAL A 344
 None
 1.29A 3s7sA-5cbmA:
0.0		 3s7sA-5cbmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 GLY A 402
ALA A 485
PHE A 591
ALA A 500
VAL A 524
 None
 1.24A 4ryaA-5cbmA:
undetectable		 4ryaA-5cbmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 ALA A 428
ALA A 340
SER A 448
ALA A 469
 None
 0.77A 4twdF-5cbmA:
0.6
4twdG-5cbmA:
undetectable
4twdH-5cbmA:
undetectable
4twdI-5cbmA:
undetectable
4twdJ-5cbmA:
undetectable		 4twdF-5cbmA:
20.64
4twdG-5cbmA:
20.64
4twdH-5cbmA:
20.64
4twdI-5cbmA:
20.64
4twdJ-5cbmA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ILE A 576
SER A 580
TRP A 581
ALA A 300
ALA A 299
 None
 1.49A 4u14A-5cbmA:
undetectable		 4u14A-5cbmA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 PHE A 354
ALA A 469
ILE A 481
LEU A 476
 None
 1.11A 4uymB-5cbmA:
undetectable		 4uymB-5cbmA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 ILE A 574
LEU A 596
GLY A 402
LYS A 374
 None
None
None
ZN  A 702 (-2.1A)
 1.02A 4z69A-5cbmA:
undetectable		 4z69A-5cbmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 10 ALA A 469
LYS A 451
ILE A 453
VAL A 344
ALA A 428
 None
 1.07A 5nukA-5cbmA:
1.0		 5nukA-5cbmA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 9 VAL A 190
LEU A 210
PHE A 238
VAL A 224
ILE A 129
 None
 1.13A 5om2A-5cbmA:
undetectable
5om2B-5cbmA:
undetectable		 5om2A-5cbmA:
8.48
5om2B-5cbmA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 10 ALA A 469
LEU A 466
GLY A 462
ILE A 510
LEU A 514
 None
None
CO3  A 701 (-3.4A)
None
None
 1.11A 5oy01-5cbmA:
undetectable
5oy07-5cbmA:
undetectable		 5oy01-5cbmA:
10.61
5oy07-5cbmA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 SER A 391
ILE A 393
LEU A 385
GLY A 382
GLY A 381
 SO4  A 709 (-3.9A)
None
None
None
ZN  A 703 ( 4.8A)
 0.90A 5wyqA-5cbmA:
2.3		 5wyqA-5cbmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 SER A 391
ILE A 393
LEU A 385
GLY A 382
GLY A 381
 SO4  A 709 (-3.9A)
None
None
None
ZN  A 703 ( 4.8A)
 0.89A 5wyqB-5cbmA:
3.1		 5wyqB-5cbmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 12 ALA A 284
PHE A 238
VAL A 114
GLY A 268
LEU A 210
 None
 1.00A 5x24A-5cbmA:
undetectable		 5x24A-5cbmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 10 LEU A 297
VAL A 593
GLY A 590
LEU A 407
TYR A 293
 None
 1.36A 6bsiA-5cbmA:
1.9		 6bsiA-5cbmA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 ASP A 468
ALA A 428
GLU A 461
LEU A 342
 None
None
ZN  A 703 ( 2.5A)
None
 0.91A 6ci6A-5cbmA:
undetectable		 6ci6A-5cbmA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 5 SER A 343
VAL A 344
ASN A 432
PRO A 441
 None
 1.42A 6fi4A-5cbmA:
undetectable
6fi4B-5cbmA:
undetectable		 6fi4A-5cbmA:
18.55
6fi4B-5cbmA:
9.26