SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.97A 1drbB-5cc8A:
undetectable		 1drbB-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		3 / 3 ALA A 131
VAL A  39
TRP A 134
 None
 0.96A 1gmkA-5cc8A:
undetectable
1gmkB-5cc8A:
undetectable		 1gmkA-5cc8A:
5.83
1gmkB-5cc8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		3 / 3 ALA A 131
VAL A  39
TRP A 134
 None
 0.95A 1gmkC-5cc8A:
undetectable
1gmkD-5cc8A:
undetectable		 1gmkC-5cc8A:
5.83
1gmkD-5cc8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.89A 1ra2A-5cc8A:
undetectable		 1ra2A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.88A 1ra8A-5cc8A:
undetectable		 1ra8A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.89A 1rb2A-5cc8A:
undetectable		 1rb2A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.89A 1rb2B-5cc8A:
undetectable		 1rb2B-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.92A 1rd7A-5cc8A:
undetectable		 1rd7A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.91A 1rx2A-5cc8A:
undetectable		 1rx2A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.90A 1rx7A-5cc8A:
undetectable		 1rx7A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		4 / 7 ALA A 162
ASP A 249
GLY A 247
GLY A 246
 None
 0.72A 2c49B-5cc8A:
undetectable		 2c49B-5cc8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.89A 2d0kA-5cc8A:
undetectable		 2d0kA-5cc8A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.89A 2d0kB-5cc8A:
undetectable		 2d0kB-5cc8A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		4 / 7 ASP A 228
ASP A 160
GLN A 174
ARG A 182
 None
 1.16A 3s3oA-5cc8A:
undetectable		 3s3oA-5cc8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.88A 4ej1A-5cc8A:
undetectable		 4ej1A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.93A 4fhbA-5cc8A:
undetectable		 4fhbA-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.90A 4i13A-5cc8A:
undetectable		 4i13A-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.90A 4p3rA-5cc8A:
undetectable		 4p3rA-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.95A 4pssA-5cc8A:
undetectable		 4pssA-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		6 / 12 LEU A 114
THR A 119
ILE A   7
ILE A 103
ILE A  86
PHE A  99
 ANP  A 401 ( 4.6A)
ANP  A 401 (-3.9A)
ANP  A 401 (-4.0A)
None
ANP  A 401 ( 4.8A)
None
 1.38A 4rp8C-5cc8A:
undetectable		 4rp8C-5cc8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.91A 4x5iA-5cc8A:
undetectable		 4x5iA-5cc8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.90A 5eajA-5cc8A:
undetectable		 5eajA-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 VAL A  19
LEU A  69
SER A  15
GLY A 117
LEU A  84
 None
None
None
ANP  A 401 (-3.7A)
ANP  A 401 (-4.2A)
 1.18A 5m50E-5cc8A:
undetectable		 5m50E-5cc8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.93A 5ujxA-5cc8A:
undetectable		 5ujxA-5cc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.93A 5z6jA-5cc8A:
undetectable		 5z6jA-5cc8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 12 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 0.93A 5z6kA-5cc8A:
undetectable		 5z6kA-5cc8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5cc8 THIAMINE-MONOPHOSPHA
TE KINASE
(Acinetobacter
baumannii) 		5 / 11 ILE A  60
LEU A  96
PHE A  99
LEU A  84
ILE A 127
 None
None
None
ANP  A 401 (-4.2A)
None
 1.00A 5z6mA-5cc8A:
undetectable		 5z6mA-5cc8A:
19.24