SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 11 ILE A 284
LEU A 291
ILE A 258
LEU A 254
ILE A  31
 None
 1.08A 1dhiB-5cdhA:
undetectable		 1dhiB-5cdhA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 ILE A 284
LEU A 291
ILE A 258
LEU A 254
ILE A  31
 None
 1.07A 1draB-5cdhA:
undetectable		 1draB-5cdhA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 ILE A 284
LEU A 291
ILE A 258
LEU A 254
ILE A  31
 None
 1.12A 1re7B-5cdhA:
undetectable		 1re7B-5cdhA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 7 TYR A 114
LEU A 113
THR A  91
TYR A 274
 None
 1.10A 1rmtB-5cdhA:
undetectable		 1rmtB-5cdhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 8 TYR A 114
LEU A 113
THR A  91
TYR A 274
 None
 1.07A 1rmtD-5cdhA:
undetectable		 1rmtD-5cdhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 5 ILE A  92
SER A  96
ARG A  95
LEU A 276
 None
 1.14A 1y0xX-5cdhA:
undetectable		 1y0xX-5cdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 8 LEU A 200
VAL A 203
GLY A 204
ASP A 225
 None
 0.80A 2a1oA-5cdhA:
undetectable		 2a1oA-5cdhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 11 LEU A 343
LEU A 262
LEU A 277
VAL A 275
VAL A 305
 None
 1.34A 2po5B-5cdhA:
undetectable		 2po5B-5cdhA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		3 / 3 ARG A 158
ASN A 193
THR A 202
 None
 0.74A 2q63A-5cdhA:
undetectable		 2q63A-5cdhA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 LEU A 343
LEU A 262
LEU A 277
VAL A 275
VAL A 305
 None
 1.19A 2qd4A-5cdhA:
undetectable		 2qd4A-5cdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 LEU A 343
LEU A 262
LEU A 277
VAL A 275
VAL A 305
 None
 1.28A 2qd4B-5cdhA:
undetectable		 2qd4B-5cdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 5 TYR A  87
ILE A  92
LEU A 113
LEU A 110
 None
 1.12A 2zb7A-5cdhA:
undetectable		 2zb7A-5cdhA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 ILE A 284
LEU A 291
ILE A 258
LEU A 254
ILE A  31
 None
 1.08A 3drcB-5cdhA:
undetectable		 3drcB-5cdhA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 11 LEU A  54
LEU A  43
ALA A  42
ALA A 215
VAL A 209
 None
 1.25A 3e22D-5cdhA:
undetectable		 3e22D-5cdhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 9 TYR A 250
PHE A 237
ALA A 279
THR A  97
ILE A 150
 None
1PE  A 403 ( 3.9A)
None
None
None
 1.43A 3jusB-5cdhA:
undetectable		 3jusB-5cdhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 7 ILE A 258
ILE A 321
SER A 252
LEU A 346
 None
 0.76A 3ua5B-5cdhA:
undetectable		 3ua5B-5cdhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 6 LEU A 161
GLN A 244
PRO A 243
TYR A 165
 None
 1.34A 3vkxA-5cdhA:
undetectable		 3vkxA-5cdhA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 6 GLU A 171
LYS A 175
TRP A 235
GLU A 178
 None
1PE  A 402 (-3.0A)
1PE  A 402 (-4.0A)
1PE  A 402 (-3.7A)
 1.17A 4a7tA-5cdhA:
undetectable		 4a7tA-5cdhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 6 GLU A 171
LYS A 175
TRP A 235
GLU A 178
 None
1PE  A 402 (-3.0A)
1PE  A 402 (-4.0A)
1PE  A 402 (-3.7A)
 1.20A 4a7tF-5cdhA:
undetectable		 4a7tF-5cdhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 6 GLU A 171
LYS A 175
TRP A 235
GLU A 178
 None
1PE  A 402 (-3.0A)
1PE  A 402 (-4.0A)
1PE  A 402 (-3.7A)
 1.16A 4a7uA-5cdhA:
undetectable		 4a7uA-5cdhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 ILE A 284
LEU A 291
ILE A 258
LEU A 254
ILE A  31
 None
 1.09A 4dfrB-5cdhA:
undetectable		 4dfrB-5cdhA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 VAL A  41
THR A  45
PRO A  44
PRO A 218
ILE A 226
 None
 1.37A 4eb6B-5cdhA:
undetectable
4eb6C-5cdhA:
undetectable		 4eb6B-5cdhA:
21.01
4eb6C-5cdhA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 12 GLU A 241
SER A 251
LEU A 254
ILE A 258
LEU A 343
 None
 1.45A 4k38A-5cdhA:
undetectable
4k38D-5cdhA:
undetectable		 4k38A-5cdhA:
18.58
4k38D-5cdhA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 4 VAL A 287
ILE A 321
ASN A 304
VAL A  29
 None
None
1PE  A 405 (-3.6A)
None
 1.33A 5ajqA-5cdhA:
undetectable		 5ajqA-5cdhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 7 VAL A 203
THR A 206
VAL A  46
THR A  45
 None
 1.04A 5e4dA-5cdhA:
undetectable
5e4dB-5cdhA:
undetectable		 5e4dA-5cdhA:
20.43
5e4dB-5cdhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 7 ILE A 194
THR A 228
ILE A 229
SER A 232
 None
None
None
1PE  A 402 (-3.4A)
 0.76A 5fukA-5cdhA:
undetectable
5fukB-5cdhA:
undetectable		 5fukA-5cdhA:
21.35
5fukB-5cdhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 9 ASP A 281
PRO A 299
TYR A 323
LEU A 295
SER A 251
 1PE  A 403 ( 2.6A)
None
None
None
None
 1.48A 5l1fB-5cdhA:
2.6		 5l1fB-5cdhA:
19.05