SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 LEU A 384
ALA A 387
LEU A 411
LEU A 417
SER A 418
 LEU  A 384 ( 0.5A)
ALA  A 387 ( 0.0A)
LEU  A 411 ( 0.5A)
LEU  A 417 ( 0.5A)
SER  A 418 ( 0.0A)
 1.24A 1ictA-5cdnA:
undetectable
1ictC-5cdnA:
undetectable		 1ictA-5cdnA:
14.55
1ictC-5cdnA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 LEU A 459
GLU A 462
LEU A 455
VAL A 469
 LEU  A 459 ( 0.6A)
GLU  A 462 ( 0.6A)
LEU  A 455 ( 0.6A)
VAL  A 469 ( 0.6A)
 1.19A 1sn5A-5cdnA:
undetectable		 1sn5A-5cdnA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 ILE A 230
ASP A 217
PHE A 218
 ILE  A 230 ( 0.7A)
ASP  A 217 ( 0.5A)
PHE  A 218 ( 1.3A)
 0.57A 1uwjB-5cdnA:
1.8		 1uwjB-5cdnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 9 ILE A 458
GLU A 472
ARG A 137
ASP A 138
LEU A 455
 ILE  A 458 ( 0.6A)
GLU  A 472 ( 0.6A)
ARG  A 137 ( 0.6A)
ASP  A 138 ( 0.6A)
LEU  A 455 ( 0.6A)
 1.44A 3mjrA-5cdnA:
undetectable		 3mjrA-5cdnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 ARG A 238
ILE A 224
GLY A 332
SER A 240
GLY A 229
 ARG  A 238 ( 0.6A)
ILE  A 224 ( 0.7A)
GLY  A 332 ( 0.0A)
SER  A 240 ( 0.0A)
GLY  A 229 ( 0.0A)
 1.07A 4e1gB-5cdnA:
undetectable		 4e1gB-5cdnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 11 ILE A 317
ILE A 306
LEU A 327
ALA A 247
VAL A 308
 ILE  A 317 ( 0.6A)
ILE  A 306 ( 0.6A)
LEU  A 327 ( 0.6A)
ALA  A 247 ( 0.0A)
VAL  A 308 ( 0.6A)
 1.16A 4h1nA-5cdnA:
undetectable		 4h1nA-5cdnA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 ASN A  54
ASP A  40
LEU A 160
ILE A 144
 ASN  A  54 ( 0.6A)
ASP  A  40 ( 0.5A)
LEU  A 160 ( 0.6A)
ILE  A 144 ( 0.4A)
 0.97A 4k0bA-5cdnA:
undetectable		 4k0bA-5cdnA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 ASN A  54
ASP A  40
LEU A 160
ILE A 144
 ASN  A  54 ( 0.6A)
ASP  A  40 ( 0.5A)
LEU  A 160 ( 0.6A)
ILE  A 144 ( 0.4A)
 0.99A 4l7iA-5cdnA:
undetectable		 4l7iA-5cdnA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 5 ILE A 452
LEU A 371
GLU A 454
VAL A 464
 ILE  A 452 ( 0.6A)
LEU  A 371 ( 0.6A)
GLU  A 454 ( 0.6A)
VAL  A 464 ( 0.6A)
 1.00A 4nkxB-5cdnA:
undetectable		 4nkxB-5cdnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		3 / 3 VAL A 260
THR A 262
ARG A 303
 VAL  A 260 ( 0.6A)
THR  A 262 ( 0.8A)
ARG  A 303 ( 0.6A)
 0.74A 5b2tB-5cdnA:
undetectable		 5b2tB-5cdnA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 9 LEU A 209
VAL A 195
LEU A 198
ILE A 346
PRO A 165
 LEU  A 209 ( 0.6A)
VAL  A 195 ( 0.6A)
LEU  A 198 ( 0.6A)
ILE  A 346 ( 0.6A)
PRO  A 165 ( 1.1A)
 1.38A 5og9A-5cdnA:
3.6		 5og9A-5cdnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		5 / 12 GLU A 156
LEU A 136
LEU A 160
LEU A  42
ILE A  49
 GLU  A 156 (-0.5A)
LEU  A 136 ( 0.5A)
LEU  A 160 ( 0.6A)
LEU  A  42 ( 0.6A)
ILE  A  49 ( 0.6A)
 1.18A 5v0vA-5cdnA:
undetectable		 5v0vA-5cdnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 183
ILE A 131
LEU A 103
HIS A  46
 ILE  A 183 ( 0.6A)
ILE  A 131 ( 0.7A)
LEU  A 103 ( 0.6A)
HIS  A  46 ( 1.0A)
 1.01A 5vkqA-5cdnA:
3.2
5vkqB-5cdnA:
3.1		 5vkqA-5cdnA:
14.36
5vkqB-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 THR A 486
PHE A 218
HIS A 186
ILE A 213
 THR  A 486 ( 0.8A)
PHE  A 218 ( 1.3A)
HIS  A 186 ( 1.0A)
ILE  A 213 ( 0.6A)
 1.15A 5vkqA-5cdnA:
3.2
5vkqB-5cdnA:
3.2		 5vkqA-5cdnA:
14.36
5vkqB-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 THR A 486
PHE A 218
HIS A 186
ILE A 213
 THR  A 486 ( 0.8A)
PHE  A 218 ( 1.3A)
HIS  A 186 ( 1.0A)
ILE  A 213 ( 0.6A)
 1.15A 5vkqB-5cdnA:
3.2
5vkqC-5cdnA:
3.2		 5vkqB-5cdnA:
14.36
5vkqC-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 THR A 486
PHE A 218
HIS A 186
ILE A 213
 THR  A 486 ( 0.8A)
PHE  A 218 ( 1.3A)
HIS  A 186 ( 1.0A)
ILE  A 213 ( 0.6A)
 1.12A 5vkqC-5cdnA:
3.2
5vkqD-5cdnA:
3.2		 5vkqC-5cdnA:
14.36
5vkqD-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 183
ILE A 131
LEU A 103
HIS A  46
 ILE  A 183 ( 0.6A)
ILE  A 131 ( 0.7A)
LEU  A 103 ( 0.6A)
HIS  A  46 ( 1.0A)
 0.99A 5vkqA-5cdnA:
3.2
5vkqD-5cdnA:
3.2		 5vkqA-5cdnA:
14.36
5vkqD-5cdnA:
14.36