SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ce0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 12 ILE A 293
LEU A 156
GLY A 292
GLY A  45
LEU A  91
 None
 1.06A 1liiA-5ce0A:
undetectable		 1liiA-5ce0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 11 SER A  31
PHE A 354
PHE A 162
SER A  36
LEU A  73
 None
 1.41A 1q23G-5ce0A:
undetectable		 1q23G-5ce0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 11 SER A  31
PHE A 354
PHE A 162
SER A  37
LEU A  73
 None
 1.18A 1q23J-5ce0A:
undetectable		 1q23J-5ce0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 12 VAL A 358
PHE A 342
ILE A 224
LEU A 212
LEU A 309
 None
 1.07A 2jn3A-5ce0A:
1.0		 2jn3A-5ce0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 12 LEU A 260
PHE A 340
PHE A 342
PRO A 361
TYR A 216
 None
 1.05A 2w3mA-5ce0A:
undetectable		 2w3mA-5ce0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 12 PHE A  30
HIS A 305
SER A  37
ALA A  40
LEU A  73
 None
 1.28A 2xkwB-5ce0A:
undetectable		 2xkwB-5ce0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 7 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 0.91A 3ag2N-5ce0A:
undetectable
3ag2W-5ce0A:
undetectable		 3ag2N-5ce0A:
20.49
3ag2W-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 7 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 0.91A 3ag4N-5ce0A:
undetectable
3ag4W-5ce0A:
undetectable		 3ag4N-5ce0A:
20.49
3ag4W-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 9 HIS A  51
LEU A  55
ALA A  64
ILE A  66
HIS A  67
 None
 1.17A 3aptB-5ce0A:
undetectable		 3aptB-5ce0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 8 PRO A 227
PRO A 361
ASN A 360
GLY A 356
 None
 0.94A 3em0B-5ce0A:
1.1		 3em0B-5ce0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 11 GLY A  45
ALA A  46
ASP A 289
LEU A 154
ILE A  54
 None
 0.90A 3em4A-5ce0A:
undetectable		 3em4A-5ce0A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 6 PHE A  70
ASN A   8
PHE A  11
ALA A  12
 None
 1.05A 3t3sB-5ce0A:
undetectable		 3t3sB-5ce0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 6 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 1.07A 3wg7A-5ce0A:
undetectable
3wg7J-5ce0A:
undetectable		 3wg7A-5ce0A:
20.49
3wg7J-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 12 LEU A 260
PHE A 340
PHE A 342
PRO A 361
TYR A 216
 None
 1.02A 4kfjB-5ce0A:
undetectable		 4kfjB-5ce0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 10 LEU A 343
ALA A 336
PHE A 340
PHE A 263
LEU A 309
 None
 1.18A 4la0A-5ce0A:
undetectable		 4la0A-5ce0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 12 LEU A 260
PHE A 340
PHE A 342
PRO A 361
TYR A 216
 None
 1.01A 4m6kA-5ce0A:
undetectable		 4m6kA-5ce0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 8 ILE A 129
LEU A  97
LEU A  91
ILE A 293
 None
 0.73A 4r38A-5ce0A:
undetectable		 4r38A-5ce0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 6 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 1.05A 5b1aN-5ce0A:
undetectable
5b1aW-5ce0A:
undetectable		 5b1aN-5ce0A:
20.49
5b1aW-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 9 ASN A   8
ALA A   7
ASP A  10
GLY A  57
ILE A  54
 None
 1.27A 5kr2A-5ce0A:
undetectable		 5kr2A-5ce0A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		5 / 9 ASN A   8
ALA A   7
ASP A  10
GLY A  57
ILE A  54
 None
 1.26A 5kr2C-5ce0A:
undetectable		 5kr2C-5ce0A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 6 LEU A  15
SER A  14
PHE A  11
ASP A  10
 None
 1.06A 5om3A-5ce0A:
34.1
5om3B-5ce0A:
undetectable		 5om3A-5ce0A:
21.84
5om3B-5ce0A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 6 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 1.00A 6nmfN-5ce0A:
undetectable
6nmfW-5ce0A:
undetectable		 6nmfN-5ce0A:
20.49
6nmfW-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)
(synthetic
construct) 		4 / 5 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 0.87A 6nmpN-5ce0A:
undetectable
6nmpW-5ce0A:
undetectable		 6nmpN-5ce0A:
20.49
6nmpW-5ce0A:
10.51