SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ce6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 12 VAL A 108
ILE A  23
PHE A  81
LEU A 122
MET A  86
 None
 1.01A 1qhyA-5ce6A:
undetectable		 1qhyA-5ce6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 12 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.12A 1xzxX-5ce6A:
undetectable		 1xzxX-5ce6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 12 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.15A 1y0xX-5ce6A:
undetectable		 1y0xX-5ce6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		3 / 3 PHE A 190
VAL A 186
TRP A  47
 None
 0.85A 2cc8A-5ce6A:
undetectable		 2cc8A-5ce6A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		3 / 3 PHE A 190
VAL A 186
TRP A  47
 None
 0.84A 2ccbA-5ce6A:
undetectable		 2ccbA-5ce6A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 11 ILE A 205
GLY A 377
THR A 376
GLU A 384
GLY A 379
 None
 1.48A 2fn1B-5ce6A:
undetectable		 2fn1B-5ce6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 11 GLY A 379
GLY A 377
GLU A 384
ALA A  71
THR A 431
 None
None
None
ACT  A 501 (-3.8A)
None
 1.27A 2vdvF-5ce6A:
undetectable		 2vdvF-5ce6A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		4 / 6 LEU A 248
SER A 284
PHE A 270
GLU A 244
 None
 1.28A 2vn1B-5ce6A:
undetectable		 2vn1B-5ce6A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		3 / 3 PHE A 190
VAL A 186
TRP A  47
 None
 0.84A 2vx9A-5ce6A:
undetectable		 2vx9A-5ce6A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		4 / 5 LEU A 122
LYS A 101
LEU A 105
GLU A 106
 None
 1.10A 3h5gA-5ce6A:
undetectable
3h5gB-5ce6A:
undetectable		 3h5gA-5ce6A:
6.44
3h5gB-5ce6A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 12 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.15A 4lnwA-5ce6A:
undetectable		 4lnwA-5ce6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 12 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.17A 4lnxA-5ce6A:
undetectable		 4lnxA-5ce6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 12 VAL A  55
ALA A  54
VAL A  87
PHE A 194
GLY A 157
 None
 1.27A 4mm4B-5ce6A:
undetectable		 4mm4B-5ce6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 9 VAL A  55
ALA A  54
GLY A 189
PHE A 190
GLY A 157
 None
 1.28A 4mm5A-5ce6A:
undetectable		 4mm5A-5ce6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 9 VAL A  55
ALA A  54
GLY A 189
PHE A 190
GLY A 157
 None
 1.34A 4mmfA-5ce6A:
undetectable		 4mmfA-5ce6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 9 VAL A  55
ALA A  54
GLY A 189
PHE A 190
GLY A 157
 None
 1.30A 4mmfB-5ce6A:
undetectable		 4mmfB-5ce6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		4 / 6 PHE A 316
SER A 272
HIS A 236
LEU A 224
 None
NA  A 504 (-3.0A)
NA  A 504 (-4.5A)
None
 1.33A 5dzke-5ce6A:
undetectable
5dzks-5ce6A:
undetectable		 5dzke-5ce6A:
19.54
5dzks-5ce6A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		5 / 12 ALA A 327
TYR A 328
PHE A 382
ILE A 378
GLY A 302
 None
 1.09A 5fsaA-5ce6A:
undetectable		 5fsaA-5ce6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5ce6 FACT-SPT16
(Cicer
arietinum) 		4 / 8 GLN A 410
ALA A 374
GLN A 335
SER A 406
 None
None
None
ACT  A 502 (-3.1A)
 1.07A 5km8A-5ce6A:
undetectable
5km8B-5ce6A:
undetectable		 5km8A-5ce6A:
14.74
5km8B-5ce6A:
14.74