SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ce8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 12 ILE A 207
LEU A 208
GLY A 185
SER A 186
GLU A 184
 None
PLP  A 301 (-3.7A)
None
None
PLP  A 301 (-2.7A)
 1.07A 1kyvB-5ce8A:
undetectable
1kyvC-5ce8A:
undetectable		 1kyvB-5ce8A:
19.16
1kyvC-5ce8A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 6 GLU A 188
LEU A 125
ASP A 171
GLY A 169
 None
 0.85A 1n13H-5ce8A:
undetectable
1n13K-5ce8A:
undetectable		 1n13H-5ce8A:
19.33
1n13K-5ce8A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 7 LEU A 125
ASP A 171
GLY A 169
GLU A 188
 None
 0.88A 1n13G-5ce8A:
undetectable
1n13J-5ce8A:
undetectable		 1n13G-5ce8A:
10.96
1n13J-5ce8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 8 TYR A  91
ARG A  93
GLY A 247
THR A 248
ALA A 249
 None
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
 0.49A 2a1hA-5ce8A:
30.9
2a1hB-5ce8A:
30.9		 2a1hA-5ce8A:
26.19
2a1hB-5ce8A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		6 / 10 TYR A  91
ARG A  93
TYR A 124
GLY A 247
THR A 248
ALA A 249
 None
None
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
 0.52A 2coiA-5ce8A:
31.5
2coiB-5ce8A:
31.8		 2coiA-5ce8A:
25.00
2coiB-5ce8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		6 / 10 TYR A  91
ARG A  93
TYR A 124
GLY A 247
THR A 248
ALA A 249
 None
None
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
 0.49A 2coiA-5ce8A:
31.5
2coiB-5ce8A:
31.8		 2coiA-5ce8A:
25.00
2coiB-5ce8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		7 / 11 PHE A  31
TYR A  91
ARG A  93
TYR A 124
GLY A 247
THR A 248
ALA A 249
 None
None
None
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
 0.49A 2cojA-5ce8A:
31.4
2cojB-5ce8A:
31.5		 2cojA-5ce8A:
25.00
2cojB-5ce8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 9 TYR A  91
ARG A  93
GLY A 247
THR A 248
ALA A 249
 None
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
 0.37A 2cojA-5ce8A:
31.4
2cojB-5ce8A:
31.5		 2cojA-5ce8A:
25.00
2cojB-5ce8A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		8 / 8 TYR A  91
ARG A  93
GLY A 187
GLU A 188
GLY A 247
THR A 248
ALA A 249
ALA A 250
 None
None
PLP  A 301 ( 4.3A)
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
None
 0.34A 2ej3A-5ce8A:
40.7		 2ej3A-5ce8A:
43.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		10 / 10 PHE A  31
TYR A  91
ARG A  93
TYR A 155
GLY A 187
GLU A 188
GLY A 247
THR A 248
ALA A 249
ALA A 250
 None
None
None
PLP  A 301 (-3.9A)
PLP  A 301 ( 4.3A)
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
None
 0.40A 2ej3B-5ce8A:
40.5		 2ej3B-5ce8A:
43.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 8 GLU A 188
LEU A 125
ASP A 171
GLY A 169
 None
 0.90A 2qqdB-5ce8A:
undetectable
2qqdC-5ce8A:
undetectable		 2qqdB-5ce8A:
19.33
2qqdC-5ce8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		3 / 3 LYS A  87
ARG A  82
VAL A  81
 None
 0.85A 2r2vC-5ce8A:
undetectable
2r2vD-5ce8A:
undetectable		 2r2vC-5ce8A:
10.68
2r2vD-5ce8A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 6 VAL A 182
VAL A 246
ILE A 207
ARG A 194
 None
 0.97A 3ms9A-5ce8A:
undetectable		 3ms9A-5ce8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 11 VAL A 147
PHE A  31
GLY A 187
TYR A 124
GLU A 184
 None
None
PLP  A 301 ( 4.3A)
None
PLP  A 301 (-2.7A)
 1.14A 3owxA-5ce8A:
undetectable
3owxB-5ce8A:
undetectable		 3owxA-5ce8A:
22.53
3owxB-5ce8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 4 TYR A  91
TYR A 124
GLU A 188
GLY A 187
 None
None
None
PLP  A 301 ( 4.3A)
 1.23A 3reqA-5ce8A:
undetectable		 3reqA-5ce8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		3 / 3 ASN A  84
ALA A  83
LYS A   2
 None
 0.93A 3runA-5ce8A:
undetectable		 3runA-5ce8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 12 LEU A  64
VAL A  66
SER A  99
SER A  21
VAL A  95
 None
 1.50A 3vt3A-5ce8A:
undetectable		 3vt3A-5ce8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 12 GLY A 187
TYR A 124
GLU A 184
VAL A 147
PHE A  31
 PLP  A 301 ( 4.3A)
None
PLP  A 301 (-2.7A)
None
None
 1.13A 4fglA-5ce8A:
undetectable
4fglB-5ce8A:
undetectable		 4fglA-5ce8A:
22.53
4fglB-5ce8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 7 TYR A 238
VAL A 182
ILE A 192
ALA A 240
 None
 0.90A 4lv9B-5ce8A:
undetectable		 4lv9B-5ce8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 7 VAL A 246
ILE A 272
ILE A 219
ALA A 220
 None
 0.89A 4lv9B-5ce8A:
undetectable		 4lv9B-5ce8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		4 / 5 ALA A 161
ARG A 166
ALA A 133
GLU A 172
 None
 1.47A 5a06C-5ce8A:
undetectable
5a06D-5ce8A:
undetectable		 5a06C-5ce8A:
20.85
5a06D-5ce8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 12 ILE A 279
ILE A 219
THR A 212
ASN A 189
ILE A 252
 None
None
PLP  A 301 (-3.6A)
PLP  A 301 ( 3.7A)
None
 1.22A 5lg3J-5ce8A:
undetectable		 5lg3J-5ce8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 12 GLU A 184
VAL A 182
PRO A 201
THR A 200
THR A 215
 PLP  A 301 (-2.7A)
None
None
None
None
 1.47A 5xipD-5ce8A:
undetectable		 5xipD-5ce8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		5 / 12 GLU A 184
VAL A 182
PRO A 201
THR A 200
THR A 215
 PLP  A 301 (-2.7A)
None
None
None
None
 1.44A 5xiqC-5ce8A:
undetectable		 5xiqC-5ce8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermoproteus
uzoniensis) 		6 / 12 VAL A 216
THR A 212
VAL A 197
LEU A 198
PHE A 244
GLY A 247
 None
PLP  A 301 (-3.6A)
None
None
None
PLP  A 301 ( 3.7A)
 1.28A 6drzA-5ce8A:
undetectable		 6drzA-5ce8A:
20.57