SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 9 LEU A 132
LYS A 340
ILE A 335
VAL A  64
PHE A  95
 None
 1.40A 1gx8A-5ceeA:
undetectable		 1gx8A-5ceeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 11 LEU A 132
LYS A 340
ILE A 335
VAL A  64
PHE A  95
 None
 1.32A 1gx9A-5ceeA:
undetectable		 1gx9A-5ceeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 12 ILE A 199
GLY A 191
GLY A 193
SER A 194
ALA A 198
 None
NAD  A 401 (-3.0A)
NAD  A 401 (-3.4A)
NAD  A 401 (-4.5A)
None
 0.97A 1i9gA-5ceeA:
undetectable		 1i9gA-5ceeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		3 / 3 VAL A 167
ALA A 164
HIS A 161
 None
 0.72A 1q23L-5ceeA:
undetectable		 1q23L-5ceeA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		3 / 3 VAL A 167
ALA A 164
HIS A 161
 None
 0.73A 1q23J-5ceeA:
undetectable		 1q23J-5ceeA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		4 / 7 LEU A 283
VAL A 260
GLY A 259
VAL A 187
 NAD  A 401 (-4.2A)
NAD  A 401 (-3.5A)
None
None
 1.00A 1t88A-5ceeA:
undetectable		 1t88A-5ceeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 10 VAL A 314
ILE A 361
GLY A 170
ILE A 258
LEU A 283
 NAD  A 401 (-4.0A)
None
None
None
NAD  A 401 (-4.2A)
 1.07A 1z11D-5ceeA:
undetectable		 1z11D-5ceeA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		6 / 12 LEU A 204
LEU A 234
LEU A 213
ILE A 189
ILE A 199
ALA A 198
 None
 1.33A 2bxqA-5ceeA:
undetectable		 2bxqA-5ceeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 12 VAL A 266
LEU A 247
VAL A 250
VAL A 212
GLY A 259
 None
 1.16A 2cbrA-5ceeA:
undetectable		 2cbrA-5ceeA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		4 / 9 ILE A 335
ALA A 375
VAL A 378
LYS A 383
 None
 0.98A 2vufB-5ceeA:
2.6		 2vufB-5ceeA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 11 ILE A 279
ALA A 304
LEU A 283
ILE A 171
ILE A 189
 None
None
NAD  A 401 (-4.2A)
None
None
 0.89A 2w9sA-5ceeA:
undetectable		 2w9sA-5ceeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 11 ILE A 279
ALA A 304
LEU A 283
ILE A 171
ILE A 189
 None
None
NAD  A 401 (-4.2A)
None
None
 0.86A 2w9sB-5ceeA:
undetectable		 2w9sB-5ceeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 10 ILE A 279
ALA A 304
LEU A 283
ILE A 171
ILE A 189
 None
None
NAD  A 401 (-4.2A)
None
None
 0.87A 2w9sC-5ceeA:
undetectable		 2w9sC-5ceeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		4 / 8 ILE A 279
ALA A 304
LEU A 283
ILE A 171
 None
None
NAD  A 401 (-4.2A)
None
 0.82A 2w9sE-5ceeA:
undetectable		 2w9sE-5ceeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 12 ILE A 199
GLY A 191
GLY A 193
SER A 194
ALA A 198
 None
NAD  A 401 (-3.0A)
NAD  A 401 (-3.4A)
NAD  A 401 (-4.5A)
None
 0.84A 2yvlA-5ceeA:
5.2		 2yvlA-5ceeA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		4 / 5 ILE A 101
SER A 103
PHE A 104
PRO A 105
 None
 1.37A 3bjwC-5ceeA:
undetectable		 3bjwC-5ceeA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 9 ALA A 304
LEU A 283
ILE A 189
LEU A 203
ILE A 256
 None
NAD  A 401 (-4.2A)
None
None
None
 1.13A 3jw3B-5ceeA:
undetectable		 3jw3B-5ceeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 12 ARG A 325
LEU A 328
VAL A  21
GLY A  19
GLY A 100
 None
 0.95A 3ku1A-5ceeA:
2.4		 3ku1A-5ceeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		4 / 5 PHE A 281
ILE A 290
ASN A 360
PHE A 257
 None
 0.95A 3octA-5ceeA:
undetectable		 3octA-5ceeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 9 ILE A 279
ALA A 304
LEU A 283
ILE A 189
ILE A 256
 None
None
NAD  A 401 (-4.2A)
None
None
 1.23A 3tq8A-5ceeA:
undetectable		 3tq8A-5ceeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 12 PHE A 156
VAL A 323
GLU A 144
HIS A 161
VAL A 166
 None
 1.09A 4a97B-5ceeA:
undetectable
4a97C-5ceeA:
undetectable		 4a97B-5ceeA:
19.01
4a97C-5ceeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 12 PHE A 156
VAL A 323
ILE A 374
GLU A 144
HIS A 161
 None
 1.28A 4a97B-5ceeA:
undetectable
4a97C-5ceeA:
undetectable		 4a97B-5ceeA:
19.01
4a97C-5ceeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 12 VAL A 266
VAL A 188
VAL A 260
GLY A 191
LEU A 247
 None
None
NAD  A 401 (-3.5A)
NAD  A 401 (-3.0A)
None
 1.12A 5iktA-5ceeA:
undetectable		 5iktA-5ceeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		5 / 11 GLY A 326
ASP A 329
ALA A 375
PRO A 321
ILE A 101
 None
 1.07A 5yk2A-5ceeA:
undetectable		 5yk2A-5ceeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5cee NAD-DEPENDENT MALIC
ENZYME
(Aster
yellows
witches'-broom
phytoplasma) 		4 / 5 TYR A  55
VAL A  40
MET A  63
GLY A 128
 None
 1.13A 6hd4A-5ceeA:
undetectable		 6hd4A-5ceeA:
12.17