SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 11 SER A 110
SER A  87
ASN A 111
GLY A  19
GLY A  10
 None
 0.97A 1jr1A-5cefA:
undetectable		 1jr1A-5cefA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 10 SER A 110
SER A  87
ASN A 111
GLY A  19
GLY A  10
 None
 1.15A 1mehA-5cefA:
undetectable		 1mehA-5cefA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 4 SER A 208
ILE A 207
VAL A 194
THR A  17
 None
 0.91A 1u70A-5cefA:
undetectable		 1u70A-5cefA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 TYR A 281
ALA A 293
ILE A 124
ILE A 221
LEU A 345
 None
 1.34A 2bjfA-5cefA:
undetectable		 2bjfA-5cefA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 6 ALA A 358
TYR A 149
TYR A 109
ILE A 136
 None
 1.17A 2dcfA-5cefA:
undetectable		 2dcfA-5cefA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 8 ALA A 297
ALA A 295
GLY A 289
ALA A 293
 None
 0.92A 2vh3B-5cefA:
undetectable		 2vh3B-5cefA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 9 ILE A 334
PHE A 278
ALA A 277
VAL A 274
 None
 0.86A 2vufA-5cefA:
undetectable		 2vufA-5cefA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 7 ALA A 358
TYR A 149
TYR A 109
ILE A 136
 None
 1.19A 2zm7A-5cefA:
undetectable		 2zm7A-5cefA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 5 PRO A 164
VAL A 162
THR A 349
GLY A 346
 None
 1.17A 3elzB-5cefA:
undetectable		 3elzB-5cefA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 10 ILE A  23
SER A  87
GLY A  19
SER A 351
LEU A  34
 None
 1.39A 3ik6B-5cefA:
undetectable
3ik6E-5cefA:
undetectable		 3ik6B-5cefA:
21.32
3ik6E-5cefA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 10 SER A 351
LEU A  34
ILE A  23
SER A  87
GLY A  19
 None
 1.40A 3iluB-5cefA:
undetectable
3iluE-5cefA:
undetectable		 3iluB-5cefA:
21.32
3iluE-5cefA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 11 ILE A  23
SER A  87
GLY A  19
SER A 351
LEU A  34
 None
 1.39A 3iluB-5cefA:
undetectable
3iluE-5cefA:
undetectable		 3iluB-5cefA:
21.32
3iluE-5cefA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 9 GLY A 318
LEU A 127
LEU A 345
ASP A 341
ASN A 314
 None
 1.09A 3wdmC-5cefA:
3.0		 3wdmC-5cefA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 8 SER A 110
SER A  87
ASN A 111
GLY A  10
 None
 1.00A 4af0A-5cefA:
undetectable		 4af0A-5cefA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 8 PRO A 164
VAL A 163
PRO A 126
ILE A 340
 None
None
None
EDO  A 401 (-4.6A)
 1.06A 4iilA-5cefA:
5.1		 4iilA-5cefA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 8 PRO A 130
ALA A 166
TYR A 281
ASP A 284
 None
 1.06A 4k0bB-5cefA:
undetectable		 4k0bB-5cefA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 8 PRO A 130
ALA A 166
TYR A 281
ASP A 284
 None
 1.01A 4l7iB-5cefA:
undetectable		 4l7iB-5cefA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 5 THR A 159
THR A 158
HIS A 132
ASN A 354
 None
 0.94A 4pgfB-5cefA:
3.0		 4pgfB-5cefA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 PHE A  22
VAL A  11
ALA A  39
TYR A  48
GLY A  13
 None
 1.27A 5tzoC-5cefA:
undetectable		 5tzoC-5cefA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		4 / 5 VAL A 180
THR A 182
LEU A 165
VAL A 128
 None
EDO  A 401 (-3.9A)
None
None
 1.00A 6bqgA-5cefA:
undetectable		 6bqgA-5cefA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Cryptococcus
neoformans) 		5 / 12 ALA A 348
GLY A  13
GLY A  19
SER A  40
ASP A  90
 None
 1.14A 6clxA-5cefA:
3.6		 6clxA-5cefA:
22.60